Procaterol hydrochloride containing drug combination for treatment of children bronchial asthma and preparation method of proaterol hydrochloride containing drug combination

A technology for procaterol hydrochloride and bronchial asthma, applied in the field of medicine, can solve problems such as restricting the use of procaterol hydrochloride, and achieve the effects of avoiding digestive tract reaction, improving treatment effect and improving effect

Inactive Publication Date: 2016-12-14
于明启
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Procaterol hydrochloride is likely to cause nausea and stomach discomfort and other gastrointestinal side effects
This adverse reaction severely limits the clinical use of Procaterol hydrochloride

Method used

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  • Procaterol hydrochloride containing drug combination for treatment of children bronchial asthma and preparation method of proaterol hydrochloride containing drug combination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A pharmaceutical composition for treating children with bronchial asthma, comprising the following raw materials in proportions by weight:

[0033] Procaterol hydrochloride 50mg, ephedra 3000g, Tinglizi 3000g, amomum 3000g, woody 3000g.

[0034] The preparation method of the pharmaceutical composition for treating children's bronchial asthma:

[0035] a. Add water to decoct ephedra, Tinglizi, amomum, and woody spices for 2 times, add 8 volumes of water for the first time, decoct for 1 hour, add 6 times the volume of medicine for the second time, and decoct for 0.5 hours, combine the decoction and set aside;

[0036] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.07~1.10, add ethanol until the alcohol content is 80%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.14~1.18 clear ointment, spray-dried to obtain dry powder;

[0037] c. Procaterol hydrochloride is mixed with d...

Embodiment 2

[0041] A pharmaceutical composition for treating children with bronchial asthma, comprising the following raw materials in proportions by weight:

[0042] Procaterol hydrochloride 45mg, ephedra 2500000mg, Tinglizi 3500000mg, amomum 2500000mg, woody 3500000mg.

[0043] The preparation method of the pharmaceutical composition for treating children's bronchial asthma:

[0044]a. Add water to decoct ephedra, Tinglizi, amomum, and woody spice twice, add 7 volumes of water for the first time, decoct for 0.5 hours, add 5 times the volume of medicine for the second time, decoct for 0.5 hours, combine the decoction and set aside;

[0045] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.07~1.10, add ethanol until the alcohol content is 80%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.14~1.18 clear ointment, spray-dried to obtain dry powder;

[0046] c. Procaterol hydrochloride is mixed...

Embodiment 3

[0050] A pharmaceutical composition for treating children with bronchial asthma, comprising the following raw materials in proportions by weight:

[0051] Procaterol hydrochloride 55mg, ephedra 2500g, Tinglizi 3500g, amomum 2500g, woody 3500g.

[0052] The preparation method of the pharmaceutical composition for treating children's bronchial asthma:

[0053] a. Add water to decoct ephedra, Tinglizi, amomum, and woody spices for 2 times, add water 9 times the volume of the drug for the first time, decoct for 1.5 hours, add water 7 times the volume of the drug for the second time, and decoct for 0.5 hours, combine the decoction and set aside;

[0054] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.07~1.10, add ethanol until the alcohol content is 80%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.14~1.18 clear ointment, spray-dried to obtain dry powder;

[0055] c. Procaterol hy...

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PUM

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Abstract

The invention belongs to the technical field of medicine and particularly relates to a procaterol hydrochloride containing drug combination for treatment of children bronchial asthma and a preparation method of the procaterol hydrochloride containing drug combination. The procaterol hydrochloride containing drug combination is composed of raw materials including, by weight, 40-60 parts of procaterol hydrochloride, 2000000-4000000 parts of ephedra sinica stapf, 2000000-4000000 parts of semen lepidii, 2000000-4000000 parts of fructus amomi and 2000000-4000000 parts of radix aucklandiae. In the method, traditional Chinese medicine is combined with the procaterol hydrochloride, so that common adverse reactions of the procaterol hydrochloride can be avoided, and treatment effect on children bronchial asthma is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing procaterol hydrochloride for treating bronchial asthma in children and a preparation method thereof. Background technique [0002] Bronchial asthma, referred to as asthma, is a chronic allergic inflammatory disease of the airway. It is a chronic inflammatory disease of the airway that is composed of a variety of inflammatory cells and participates in it. The clinical manifestations are recurrent symptoms such as wheezing, coughing, shortness of breath, and chest tightness, which often occur or aggravate at night or early in the morning. It is the most common chronic respiratory disease in children. According to relevant studies, the incidence rate has been increasing worldwide in recent years, which not only seriously affects the growth and development of children, but also brings a huge burden to society and families. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P11/06A61K31/4704
CPCA61K31/4704A61K36/17A61K36/285A61K36/31A61K36/9064A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 于明启
Owner 于明启
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