Dihydroergotamine-containing pharmaceutical composition for treating pelvic congestion syndrome and preparation method thereof

A technology of dihydroergotamine and pelvic blood stasis, which is applied in the field of medicine, can solve the problems of restricting the use of dihydroergotamine, and achieve the effects of avoiding digestive tract reactions, improving therapeutic effect, and less side effects

Inactive Publication Date: 2016-10-26
栾福娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, dihydroergotamine is likely to cause nausea and stomach discomfort and other gastrointestinal side effects
This adverse reaction severely limits the clinical use of dihydroergotamine

Method used

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  • Dihydroergotamine-containing pharmaceutical composition for treating pelvic congestion syndrome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A pharmaceutical composition for the treatment of pelvic congestion syndrome, comprising the following raw materials in proportions by weight:

[0033] Dihydroergotamine 3g, Danshen 3000g, motherwort 3000g, inula 3000g, woody 3000g, ginger 3000g.

[0034] The preparation method of the pharmaceutical composition for the treatment of pelvic congestion syndrome:

[0035] a. Add salvia miltiorrhiza, motherwort, inula inulae, wood fragrance, and ginger to decoct twice, add 7 volumes of water for the first time, decoct for 1.5 hours, add water 5 times the volume of the medicine for the second time, decoct for 1 hour hours, combine the decoction and set aside;

[0036] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[00...

Embodiment 2

[0041] A pharmaceutical composition for the treatment of pelvic congestion syndrome, comprising the following raw materials in proportions by weight:

[0042] Dihydroergotamine 2.5g, Salvia miltiorrhiza 3500g, Motherwort 2500g, Inula inulae 3500g, Muxiang 2500g, Ginger 3500g.

[0043] The preparation method of the pharmaceutical composition for the treatment of pelvic congestion syndrome:

[0044] a. Add water to decoct Salvia miltiorrhiza, motherwort, inula inulae, wood fragrance, and ginger for 2 times, add 8 volumes of water for the first time, decoct for 2 hours, add 6 times the volume of medicine for the second time, decoct for 1.5 hours, combine the decoction and set aside;

[0045] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtai...

Embodiment 3

[0050] A pharmaceutical composition for the treatment of pelvic congestion syndrome, comprising the following raw materials in proportions by weight:

[0051] Dihydroergotamine 3.5g, Salvia miltiorrhiza 2500g, Motherwort 3500g, Inula inula 2500g, Muxiang 3500g, Ginger 2500g.

[0052] The preparation method of the pharmaceutical composition for the treatment of pelvic congestion syndrome:

[0053] a. Add salvia miltiorrhiza, motherwort, inula inulae, wood fragrance, and ginger to decoct twice, add 6 volumes of water for the first time, decoct for 1 hour, add water 4 times the volume of the medicine for the second time, decoct for 0.5 hours, combine the decoction and set aside;

[0054] b. Concentrate the decoction liquid at 65°C and -0.04Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry ...

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Abstract

The invention belongs to the technical field of medicines and relates to a dihydroergotamine-containing pharmaceutical composition for treating pelvic congestion syndrome and a preparation method thereof. The dihydroergotamine-containing pharmaceutical composition comprises, by weight, 2-4 parts of dihydroergotamine, 2000-4000 parts of red sage root, 2000-4000 parts of motherwort, 2000-4000 parts of inula flower, 2000-4000 parts of banksia rose and 2000-4000 parts of ginger. Through combination of traditional Chinese medicines and dihydroergotamine, common gastrointestinal tract adverse reactions caused by dihydroergotamine are avoided and pelvic congestion syndrome treatment effects are improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing dihydroergotamine for treating pelvic congestion syndrome and a preparation method thereof. Background technique [0002] Pelvic congestion syndrome is a group of syndromes caused by chronic lower abdominal pain, low back pain, dyspareunia and autonomic dysfunction due to pelvic vein or venous plexus varicose and blood stasis. It is one of the important causes of chronic pelvic pain in women. [0003] At present, the most effective intervention method for pelvic congestion syndrome is drug treatment. Dihydroergotamine can selectively constrict veins, reduce venous tortuosity, and relieve pain. It is suitable for patients with pelvic congestion syndrome. However, dihydroergotamine can easily cause gastrointestinal side effects such as nausea and stomach discomfort. This adverse reaction severely limits the clinical use of dih...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/16A61K31/48A61P15/00
CPCA61K31/48A61K9/1605A61K36/28A61K36/285A61K36/533A61K36/537A61K36/9068A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 栾福娟姜瑞华
Owner 栾福娟
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