Gynecological gel containing silver ion antibacterial agent, preparation method and application

Abstract

The invention relates to the field of medical technology, especially to gynecological gel containing a silver-ion bactericide, a preparation method and application thereof. The gynecological gel containing a silver-ion bactericide comprises the following ingredients (by weight): 2.0-10.0% of glycerin, 3.0-10.0% of propylene glycol, 0.5-3.0% of carbomer, 0.4-0.6% of triethanolamine, 0.0-6.0% of blue copper polypeptide, 0.0-6.0% of alum, 0.05-0.2% of hyaluronic acid, 0.0-2.0% of water-soluble vitamin E, 0.0-6.0% of a motherwort extract, 0.0-2.0% of a witch hazel extract, 1.0-36.0% of a medicinal and edible plant extract, and the rest of a silver-ion bactericide and water, wherein use amount of the silver-ion bactericide is the use amount which makes concentration of silver ion in the gynecological gel to be 0.05-5.0 ppm; and the medicinal and edible plant extract contains a purslane extract which accounts for 1.0-6.0% of total mass of the gynecological gel. The gel of the invention is efficient, safe and mild, and can be used for greatly treating various gynecological diseases and nursing the vagina.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the formula, preparation method and application of gynecological gel containing silver ion antibacterial agent. Background technique [0002] Researchers at home and abroad have extensively screened fungicides according to the purpose of sterilization and the characteristics of disinfection objects, but no ideal antibacterial agent has been found so far. Aldehyde and acid antibacterial agents (formaldehyde, benzoic acid) have a wide bactericidal spectrum, but are highly toxic, corrosive, and irritating to the vaginal mucous membrane and skin; chlorine preparations (triclosin, chlorhexidine acetate, dioxide Chlorine, hypochlorous acid) have low effective concentration, fast action speed and stable properties, but are easily affected by organic matter, acid, alkali and other physical and chemical factors, and are also more irritating to vaginal mucosa and skin. [0003] Therefore...

AI Technical Summary

Problems solved by technology

[0005] Not only that, whether the existing formula technology adopts traditional aldehyde acid antibacterial agents (formaldehyde, benzoic acid), chlorine preparations (triclosin, chlorhexidine acetate, chlorine dioxide, hypochlorous acid), or relatively novel Both nano-silver antibacterial agents and colloidal silver antibacterial agents have the defects that the antibacterial effect is not very ideal and their own stability is not good (discoloration, acidity change)

[0006] In addition, in the prior art, most of the nursing ingredients for vaginal mucosa repair use some Western medicine ingredients such as heparin sodium, nicotinamide, chlorpheniramine, lidocaine, etc., which are more irritating to the vaginal mucosa; The ingredients of Chinese herbal medicines, such as Scutellaria baicalensis, Tieshidou, Sophora flavescens, Fructus Cnidii, Baibu, Cortex Phellodendri, etc., are also irritating to the vaginal mucous membrane.

In addition, even if the vaginal mucosa repairing and nursing ingredients in the prior art gel are selected to add less irritating Chinese herbal medicine ingredients, what is added is Chinese herbal medicine extract, the active ingredient content is very small, and the repairing and nursing effect is very poor.

However, powders of medicinal and edible Chinese herbal medicines are generally directly used in oral medicines, and there are few reports on external medicines, especially vaginal medicines for the treatment of gynecological diseases.