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Gynecological gel containing silver-ion bactericide, preparation method and application thereof

The technology of silver ion antibacterial agent and gel, which is applied in the field of medicine, can solve the problems of large irritation of vaginal mucosa, change in acidity, poor repair and nursing effect, etc., and achieve the effects of high antibacterial efficiency and stable antibacterial efficiency.

Active Publication Date: 2017-01-18
广州洁康医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Not only that, whether the existing formula technology adopts traditional aldehyde acid antibacterial agents (formaldehyde, benzoic acid), chlorine preparations (triclosin, chlorhexidine acetate, chlorine dioxide, hypochlorous acid), or relatively novel Both nano-silver antibacterial agents and colloidal silver antibacterial agents have the defects that the antibacterial effect is not very ideal and their own stability is not good (discoloration, acidity change)
[0006] In addition, in the prior art, most of the nursing ingredients for vaginal mucosa repair use some Western medicine ingredients such as heparin sodium, nicotinamide, chlorpheniramine, lidocaine, etc., which are more irritating to the vaginal mucosa; The ingredients of Chinese herbal medicines, such as Scutellaria baicalensis, Tieshidou, Sophora flavescens, Fructus Cnidii, Baibu, Cortex Phellodendri, etc., are also irritating to the vaginal mucous membrane.
In addition, even if the vaginal mucosa repairing and nursing ingredients in the prior art gel are selected to add less irritating Chinese herbal medicine ingredients, what is added is Chinese herbal medicine extract, the active ingredient content is very small, and the repairing and nursing effect is very poor.
However, powders of medicinal and edible Chinese herbal medicines are generally directly used in oral medicines, and there are few reports on external medicines, especially vaginal medicines for the treatment of gynecological diseases.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A gynecological gel containing silver ion antibacterial agent, comprising the following components by mass percentage: glycerin 10.0%, propylene glycol 10.0%, carbomer 1.0%, triethanolamine 0.4%, blue copper polypeptide 6.0%, hyaluronic acid 0.2%, honeysuckle extract, wild chrysanthemum extract, purslane extract, centella asiatica extract, peppermint extract, aloe extract 6.0%, silver ion antibacterial agent (25ppm) 20.0%, the rest is deionized water . That is the formula of Example 1 of the present invention.

[0038] At the same time, the following three comparative formulas were made, namely:

[0039] Comparative formula 1: This comparative formula includes the following components by mass percentage: glycerin 10.0%, propylene glycol 10.0%, carbomer 1.0%, triethanolamine 0.4%, blue copper polypeptide 6.0%, hyaluronic acid 0.2%, honeysuckle extract Extract, wild chrysanthemum flower extract, purslane extract, centella asiatica extract, peppermint extract, aloe extra...

Embodiment 2

[0047] A gynecological gel containing silver ion antibacterial agent, comprising the following components by mass percentage: glycerin 8.0%, propylene glycol 8.0%, carbomer 3.0%, triethanolamine 0.6%, alum 6.0%, hyaluronic acid 0.05% , water-soluble vitamin E1.0%, witch hazel extract, purslane extract, centella asiatica extract, peppermint extract, aloe extract each 1.0%, silver ion antibacterial agent (25ppm) 12.0%, the rest is Deionized water. Be the prescription of embodiment 2.

[0048] At the same time, the following three comparative formulas were made, namely:

[0049] Comparative formula 4: This comparative formula includes the following components by mass percentage: glycerin 8.0%, propylene glycol 8.0%, carbomer 3.0%, triethanolamine 0.6%, alum 6.0%, hyaluronic acid 0.05%, water-soluble vitamin E 1.0%, 1.0% each of witch hazel extract, purslane extract, centella asiatica extract, peppermint extract, and aloe extract, and the rest is deionized water.

[0050] Compa...

Embodiment 3

[0057] A gynecological gel containing silver ion antibacterial agent, comprising the following components by mass percentage: glycerin 6.0%, propylene glycol 6.0%, carbomer 0.7%, triethanolamine 0.4%, hyaluronic acid 0.15%, water-soluble vitamin E 2.0%, witch hazel extract, honeysuckle extract, wild chrysanthemum flower extract, purslane extract, aloe extract 2.0%, silver ion antibacterial agent (25ppm) 0.2%, the rest is deionized water.

[0058] This embodiment is "Healthcare and Anti-aging Gel". The sterilizing and repairing effects of silver ions, combined with the sterilizing and repairing effects of plant extracts, and the moisturizing, nourishing and lubricating effects of hyaluronic acid and water-soluble vitamin E can all make the vagina The internal environment is in a good state, and gynecological diseases are not easy to occur, so that women can be in a healthy state for a long time. Apply the formula of this embodiment to the vaginas of 30 women aged 35-40, once a ...

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PUM

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Abstract

The invention relates to the field of medical technology, especially to gynecological gel containing a silver-ion bactericide, a preparation method and application thereof. The gynecological gel containing a silver-ion bactericide comprises the following ingredients (by weight): 2.0-10.0% of glycerin, 3.0-10.0% of propylene glycol, 0.5-3.0% of carbomer, 0.4-0.6% of triethanolamine, 0.0-6.0% of blue copper polypeptide, 0.0-6.0% of alum, 0.05-0.2% of hyaluronic acid, 0.0-2.0% of water-soluble vitamin E, 0.0-6.0% of a motherwort extract, 0.0-2.0% of a witch hazel extract, 1.0-36.0% of a medicinal and edible plant extract, and the rest of a silver-ion bactericide and water, wherein use amount of the silver-ion bactericide is the use amount which makes concentration of silver ion in the gynecological gel to be 0.05-5.0 ppm; and the medicinal and edible plant extract contains a purslane extract which accounts for 1.0-6.0% of total mass of the gynecological gel. The gel of the invention is efficient, safe and mild, and can be used for greatly treating various gynecological diseases and nursing the vagina.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the formula, preparation method and application of gynecological gel containing silver ion antibacterial agent. Background technique [0002] Researchers at home and abroad have extensively screened fungicides according to the purpose of sterilization and the characteristics of disinfection objects, but no ideal antibacterial agent has been found so far. Aldehyde and acid antibacterial agents (formaldehyde, benzoic acid) have a wide bactericidal spectrum, but are highly toxic, corrosive, and irritating to the vaginal mucous membrane and skin; chlorine preparations (triclosin, chlorhexidine acetate, dioxide Chlorine, hypochlorous acid) have low effective concentration, fast action speed and stable properties, but are easily affected by organic matter, acid, alkali and other physical and chemical factors, and are also more irritating to vaginal mucosa and skin. [0003] Therefore...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K36/886A61K36/355A61K36/287A61K36/185A61K36/23A61K36/534A61K9/06A61K47/10A61K47/36A61K47/22A61K47/18A61K47/32A61P15/02A61P15/00A61P29/00A61P33/02A61P17/10A61P9/14A61K33/38
CPCA61K9/0031A61K9/0034A61K9/06A61K33/38A61K36/185A61K36/23A61K36/287A61K36/355A61K36/534A61K36/886A61K36/896A61K47/10A61K47/18A61K47/22A61K47/32A61K47/36A61K2300/00
Inventor 叶符材
Owner 广州洁康医药科技有限公司
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