Effect of giant salamander mucus for hemostasis

A technology of giant salamander mucus and filtrate, which is applied in the field of medical technology or health food, and can solve the problems of complex composition and structure, etc.

Pending Publication Date: 2017-02-01
张家界金姑大鲵开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The whole body of the giant salamander is precious, and the mucus secreted by its epidermis is an extremely important new material that can be used in the application of hemostatic materials; however, with the rapid development of hemostatic materials, there are more and more varieties, and the composition and structure of the products are also changing more and more complicated

Method used

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  • Effect of giant salamander mucus for hemostasis
  • Effect of giant salamander mucus for hemostasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Get 10 giant salamanders, adopt vacuum method (vacuum degree 1kPa), obtain giant salamander mucus 508g;

[0047] Step (1): Take the giant salamander mucus, add 1 times the water for injection of the giant salamander mucus, heat in a water bath to 30°C, keep the system temperature at 30°C, stir for 10 minutes, add 0.5 times the ethanol of the giant salamander mucus, stir for 5 minutes, take it out of the water bath, and place it Stand at 0°C for 8 hours, filter to obtain precipitate A, and use the filtrate for later use;

[0048] Step (2): Take the filtrate from step (1), heat it in a water bath to 30°C, keep the system temperature at 30°C, add ethanol that is 3 times the size of the giant salamander mucus, stir for 5 minutes, take it out of the water bath, and place it at 0°C for 8 hours. Filtration to obtain precipitate B, and the combination of precipitate A and precipitate B to obtain precipitate;

[0049] Step (3): Take the precipitate obtained in step (2), add wat...

Embodiment 2

[0053] Get 10 giant salamanders, adopt vacuum method (vacuum degree 10kPa), obtain giant salamander mucus 496g;

[0054] Step (1): Take the giant salamander mucus, add water for injection 3 times of the giant salamander mucus, heat in a water bath to 45°C, keep the system temperature at 45°C, stir for 30 minutes, add 1.5 times the ethanol of the giant salamander mucus, stir for 10 minutes, take it out from the water bath, and place it Stand at 5°C for 12 hours, filter to obtain precipitate A, and use the filtrate for later use;

[0055] Step (2): Take the filtrate from step (1), heat it in a water bath to 45°C, keep the system temperature at 45°C, add ethanol 4 times the mucus of giant salamander, stir for 10 minutes, take it out of the water bath, and place it at 5°C for 12 hours. Filtration to obtain precipitate B, and the combination of precipitate A and precipitate B to obtain precipitate;

[0056] Step (3): Take the precipitate obtained in step (2), add water for injecti...

Embodiment 3

[0060] Get 10 giant salamanders, adopt vacuum method (vacuum degree 5kPa), obtain giant salamander mucus 513g;

[0061] Step (1): Take the giant salamander mucus, add water for injection twice as much as the giant salamander mucus, heat in a water bath to 40°C, keep the system temperature at 40°C, stir for 20 minutes, add 1 times the amount of ethanol of the giant salamander mucus, stir for 8 minutes, take it out from the water bath, and place it Stand at 3°C ​​for 10 hours, filter to obtain precipitate A, and use the filtrate for later use;

[0062] Step (2): Take the filtrate from step (1), heat it in a water bath to 40°C, keep the system temperature at 40°C, add ethanol 3.5 times the mucus of giant salamander, stir for 8 minutes, take it out from the water bath, and place it at 3°C ​​for 10 hours. Filtration to obtain precipitate B, and the combination of precipitate A and precipitate B to obtain precipitate;

[0063] Step (3): Take the precipitate obtained in step (2), ad...

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Abstract

The invention discloses an effect of giant salamander mucus for hemostasis and application of a giant salamander mucus extract in hemostatic drugs and hemostatic medical devices. The giant salamander mucus extract is used for bleeding caused by external injuries, bleeding caused by burns, bleeding caused by scalds and bleeding caused by surgery; pharmacological experiments indicate that the obtained giant salamander mucus extract has the very good hemostasis effect.

Description

technical field [0001] The invention belongs to the technical field of medical technology or health food, and specifically relates to a new application of giant salamander mucus for hemostasis. Background technique [0002] The giant salamander (Andrias davidianus Blanchard) is a large amphibian, Cauracea, and Cryptobranchidae. Its common name is "Salamander". Currently there are only 2 genera and 3 species in the family Cryptobranchidae, of which there are 2 species in the genus Giant Salamander: the Chinese giant salamander (Andrias davidianus) and the Japanese giant salamander (Andrias japonicus); the Cryptobranchus genus is only distributed in North America Cryptobranchus alleganiensis A sort of. Giant salamanders are dioecious, lay eggs on rocks from July to August, and float with the water to hatch. The giant salamander has a wide and flat head, a big mouth and small eyes, short limbs, obvious folds on both sides of the skin, and many warts on the body. The giant sa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/65A61P7/04A61L15/40A61L15/44A61L24/00A61L26/00
CPCA61L15/40A61L15/44A61L24/0005A61L24/0015A61L26/0057A61L26/0066A61K35/65A61L2400/04A61L2300/30A61L2300/418
Inventor 李俊林
Owner 张家界金姑大鲵开发有限公司
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