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Mammalian differential serum protein and differentially expressed protein system of penile smooth muscle tissue of abnormal and phlegmatic type of impotence syndrome and screening method and application

A mammalian and differential protein technology, applied in disease diagnosis, biological testing, biomaterial analysis, etc., can solve the problems of restricting the research and development of Uyghur andrology, late start, lagging research on abnormal mucus type impotence syndrome, etc. The effect of improving the level of syndrome differentiation and treatment and the level of drug research and development

Active Publication Date: 2017-05-10
XINJIANG MEDICAL UNIV
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Problems solved by technology

In the direction of clinical and basic research of Uyghur medicine, due to the late start of experimental zoology, there is no combination of related diseases and syndromes with animal models, resulting in abnormal mucus type impotence syndrome and the research on the mechanism of the corresponding prescriptions and medicines has been lagging behind, and severely restricted Uyghur medicine. In the research and development of andrology in this field, there is no research report on the related marker proteins and protein marker systems of abnormal mucus type impotence syndrome

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  • Mammalian differential serum protein and differentially expressed protein system of penile smooth muscle tissue of abnormal and phlegmatic type of impotence syndrome and screening method and application
  • Mammalian differential serum protein and differentially expressed protein system of penile smooth muscle tissue of abnormal and phlegmatic type of impotence syndrome and screening method and application
  • Mammalian differential serum protein and differentially expressed protein system of penile smooth muscle tissue of abnormal and phlegmatic type of impotence syndrome and screening method and application

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Embodiment 1

[0102] 1. Modeling and grouping

[0103]Fifteen sexually mature female mice were selected and reared under normal conditions after castration for use in mating experiments. The male rats were mated with female rats in estrus and combined with the APO erection test to confirm that they had normal sexual function (those without normal sexual function were eliminated), and 30 rats were taken into the experiment, and 10 rats were randomly selected from them as normal The control group was raised in a conventional environment with a temperature of 18-22°C, and the relative humidity of the environment was 40-60%. Modeling was carried out in a climate box, set temperature: 8-12°C, humidity 70-80%, fed alternately day and night for 12 / 12 hours, and placed in the same feeding environment as the normal group for other times. When the rats in the model group have dull skin and hair, lack of luster; tiredness, lying down and less movement; sensitive to stimulation, like to get together, ...

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Abstract

The invention provides a mammalian differential serum protein and a differentially expressed protein system of the penile smooth muscle tissue of an abnormal and phlegmatic type of impotence syndrome in uighur medicine, and a screening method of the differentially expressed protein system. The method comprises the steps that 1, a normal control group is formed, a model of a syndrome group and a disease syndrome group is built; 2, whole blood is collected, the serum and the penile smooth muscle tissue are separated; 3, protein is extracted; 4, after the labeling, purification is conducted; 5, after the detection of mass spectrum, a fingerprint spectrum is obtained, proteomics analysis is conducted after the screening, and the protein of serum and the protein of penile smooth muscle tissue of the syndrome group, the disease syndrome group and the normal control group are obtained; 6, differentially expressed protein of serum and differentially expressed protein of penile smooth muscle tissue of abnormal and phlegmatic type of impotence syndrome in uighur medicine are obtained by statistic measurements, comparisons and screening, and a foundation and a reference are provided for further mechanism research, medicine screening, conversion, and prevention and cure research on abnormal and phlegmatic type of impotence syndrome.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a mammalian serum and penile smooth muscle tissue differential protein of abnormal mucus type impotence syndrome of Uighur medicine, a screening method and application thereof. Background technique [0002] Uighur medicine (Uyghur medicine) is an important part of the traditional medicine of the motherland. Uighur medicine humor theory believes that the human body is composed of 4 kinds of humors: biliary, bloody, phlegmatic and black gallbladder. The dynamics of the above four kinds of humoral Balance is the physiological basis of a healthy body, and a change in the quantity or / and quality of a certain body fluid quality will cause the imbalance of body fluid quality and produce an abnormal body fluid quality syndrome (syndrome), which has a causal relationship with the occurrence of various diseases. Humoral pathology (humoral theory) is the basis of Uygur medicine theo...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/689G01N2800/344
Inventor 阿地力江·伊明马文静斯依提·阿木提
Owner XINJIANG MEDICAL UNIV
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