Medicine composition for treating diabetic retinopathy and preparation method thereof

A technology of diabetic retina and composition, applied in the field of pharmaceutical composition for treating diabetic retinopathy and its preparation

Inactive Publication Date: 2017-05-31
JINAN HAOYU QINGTIAN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that strict control of blood sugar can delay the occurrence and development of DR to a certain extent, but simple control of blood sugar cannot completely prevent the occurrence and development of DR.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: The pharmaceutical composition for the treatment of diabetic retinopathy and its preparation method

[0035] The composition and parts by weight of the raw material drug of the pharmaceutical composition for treating diabetic retinopathy are: 565g of Kamba Herba, 503g of Phytophthora falciparum, 206g of Annonaline, 55g of Cinnamon, 13g of Asiatic acid;

[0036] Preparation:

[0037] (1) According to the ratio of the raw materials, take the herb radix, sarcocarp, annonaline, twig, and asiatic acid, mix them evenly, use ethanol with a concentration of 38% by weight as a solvent, and soak and extract at 25.5°C to extract The number of times is 9 times, each extraction time is 42 hours, and each solvent consumption is 25 times of the total weight of the crude drug, filtered to obtain medicinal residue A and extract A, extract A reclaims ethanol, concentrates to a relative density of 1.12, and filters Afterwards, the medicinal liquid passes through the LK07 ma...

Embodiment 2

[0040] Embodiment 2: The pharmaceutical composition and preparation method thereof for the treatment of diabetic retinopathy

[0041] The composition and parts by weight of the raw material drug of the pharmaceutical composition for treating diabetic retinopathy are: 562g of Kamba japonica, 506g of Phytophthora falciparum, 204g of Annonaline, 60g of Cinnamon vine, 12g of Asiatic acid;

[0042] Preparation:

[0043] (1) According to the ratio of the raw materials, take the herb radix, sarcocarp, annonaline, twig, and asiatic acid, mix them evenly, use ethanol with a concentration of 38% by weight as a solvent, and soak and extract at 25.5°C to extract The number of times is 9 times, each extraction time is 42 hours, and each solvent consumption is 25 times of the total weight of the crude drug, filtered to obtain medicinal residue A and extract A, extract A reclaims ethanol, concentrates to a relative density of 1.12, and filters Afterwards, the medicinal liquid passes through...

Embodiment 3

[0046] Embodiment 3: the pharmaceutical composition and preparation method thereof for the treatment of diabetic retinopathy

[0047] The composition and parts by weight of the raw material drug of the pharmaceutical composition for treating diabetic retinopathy are: 568g of Kamba japonica, 500g of Phytophthora falciparum, 208g of Annonaline, 50g of Cinnamon vine, 14g of Asiatic acid;

[0048] Preparation:

[0049] (1) According to the ratio of the raw materials, take the herb radix, sarcocarp, annonaline, twig, and asiatic acid, mix them evenly, use ethanol with a concentration of 38% by weight as a solvent, and soak and extract at 25.5°C to extract The number of times is 9 times, each extraction time is 42 hours, and each solvent consumption is 25 times of the total weight of the crude drug, filtered to obtain medicinal residue A and extract A, extract A reclaims ethanol, concentrates to a relative density of 1.12, and filters Afterwards, the medicinal liquid passes through...

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PUM

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Abstract

The invention discloses a medicine composition for treating diabetic retinopathy and a preparation method thereof. The medicine composition is proportionally prepared by using herbs or roots of phyllagathis cavaleriei, pseudobulb or herbs calanthe puberula, anonaine, seeds of entada phaseoloides and asiatic acid as active pharmaceutical ingredients. The medicine composition can be prepared into various dosage forms according to a conventional preparation process; the curative effect on treating diabetic retinopathy is obvious.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a pharmaceutical composition for treating diabetic retinopathy and a preparation method thereof. Background technique [0002] Diabetic retinopathy (Diabetie retinopathy DR ) is one of the most common and serious microvascular complications of diabetes. In the past, people used general vasodilators, vitamins and other drugs for supportive therapy, but the effect was not exact. At present, DR has become one of the four major blind diseases. Long-term chronic hyperglycemia is the basis of DR pathogenesis. The basic pathological changes of DR are selective loss of pericytes, formation of microvascular tumors, thickening of capillary basement membrane, further blood-retinal barrier damage, capillary occlusion, changes in arteries and veins, and even new blood vessel formation and fiber proliferation, which eventually lead to retinal damage. detachm...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/898A61P3/10A61P9/10A61K31/56A61K31/4741
CPCA61K36/898A61K31/4741A61K31/56A61K36/185A61K36/48A61K2236/331A61K2236/39A61K2236/51A61K2236/55
Inventor不公告发明人
OwnerJINAN HAOYU QINGTIAN PHARMA TECH CO LTD