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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0022] Tinospora chinensis was collected in Simao, Yunnan in 2012, with a dry weight of 15 kg, crushed, and extracted three times with 95% ethanol at room temperature by cold soaking (25 liters each time), for 5 days each time. Recover and concentrate under reduced pressure to obtain 1100 g of the extract, which was subjected to silica gel column chromatography and eluted with petroleum ether / acetone mixed solvent gradient (99:1 to 0:100) to obtain 7 components A-G. Component E (180 g) was subjected to silica gel column chromatography and eluted with a gradient of chloroform / methanol mixed solvent (40:1 to 5:1) to obtain three components E1-E3. Component E1 was repeatedly chromatographed on a Sephadex LH-20 column and eluted with methanol to obtain 5.3 g of pure compound borapetoside E. Identification of compound structures was confirmed by comparison and interpretation of spectral data.
[0023] 1. Effect of Borapetoside E on high-fat diet (HFD)-induced hyperglycemia in mice...
Embodiment 2
[0049] Preparation of health food:
[0050] Take 15.5 mg of borapetoside E, add 200 mg of starch, 66.6 mg of lactose, 1 mg of menthol, and 50.6 mg of sodium carboxymethyl starch to make lozenges as a health food.
Embodiment 3
[0052] Preparation of injection preparations:
[0053] According to the method of Example 1, 50 mg of the compound borapetoside E of the present invention was first obtained, which was dissolved in 2 milliliters of propylene glycol, and the resulting solution was filtered and packed into ampoules under aseptic conditions.
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PUM
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Abstract
The invention relates to new application of borapetoside E for preventing and treating diabetes and hyperlipemia. A research discovers that a compound borapetoside E is capable of obviously reducing the level of blood sugar and blood lipid of HFD (High Fat Diet) induced mice and improving insulin sensitivity of the HFD induced mice. The hypoglycemic and anti-hyperlipidemic effects of 40mg / kg of the compound borapetoside E are superior to those of 200mg / kg of metformin. In addition, the duration time of the hypoglycemic effect is longer than that of 200mg / kg of the metformin, the hypoglycemic effect after drug discontinuance of single drug administration of 40mg / kg of the compound borapetoside E continues for 36 hours, and the duration time after the drug discontinuance of five times of drug administration continues for 4 days. The borapetoside E under the therapeutic dosage has no toxic and side effects, the serum glutamic pyruvic transaminase level is remarkably reduced after successive administration is carried out on the mice for 16 days, serum glutamic oxalacetic transaminase, creatine kinase and creatinine are not obviously changed, and the borapetoside E can be used for preparing drugs, healthcare products and functional food for preventing and treating the diabetes.
Description
Technical field: [0001] The invention relates to a compound borapetoside E and a new application of a drug combination using the compound as an active ingredient in the prevention and treatment of diabetes and hyperlipidemia, belonging to the technical field of medicine. [0002] technical background: [0003] According to estimates by the International Diabetes Federation, in 2013, there were 380 million people with diabetes worldwide, and more than 90% of them had type 2 diabetes. The main symptoms of type 2 diabetes are hyperglycemia, hyperlipidemia, and insulin resistance, which are also the main causes of cataracts, infections, fatty liver, cardiovascular disease, diabetic foot, and even death. Diabetes has seriously affected people's quality of life and caused a lot of medical expenses. Therefore, in addition to exercise and diet control, finding drugs for treating diabetes is still a hot spot in current pharmaceutical research. [0004] Tinospora persicae belongs to ...
Claims
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