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Composition comprising coumestrol or bean extract containing coumestrol

A technology of coumestrol and composition, which is applied in the field of composition for activating mitochondria (mitochondria), can solve the problems of lack of repair mechanism of mitochondrial DNA, being vulnerable to damage, etc., so as to prevent or reduce mitochondrial diseases, relieve fatigue, and improve mitochondrial diseases. Effect

Inactive Publication Date: 2013-01-30
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Unlike nuclear DNA, since the mitochondrial DNA ( mtDNA ) lack repair mechanisms and DNA-protecting proteins called histones, making them relatively vulnerable to damage

Method used

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  • Composition comprising coumestrol or bean extract containing coumestrol
  • Composition comprising coumestrol or bean extract containing coumestrol
  • Composition comprising coumestrol or bean extract containing coumestrol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] [Dosage Form Example 1] Soft Capsules

[0057] Mix coumestrol (80mg), vitamin E (9mg), vitamin C (9mg), palm oil (2mg), hydrogenated vegetable oil (8mg), yellow beeswax (4mg) and lecithin (9mg), and according to commonly used Methods to make soft capsule filling liquid. Each capsule is filled with 400 mg of the solution. In addition, by using gelatin (66wt%), glycerin (24wt%) and sorbitol (10wt%) to prepare a soft capsule sheet (soft capsule sheet), the filling liquid is filled in the soft capsule sheet, made containing 400mg soft capsules of the composition of the present invention.

Embodiment 2

[0058] [Dosage Form Example 2] Tablet

[0059] Coumestrol (80 mg), vitamin E (9 mg), vitamin C (9 mg), galacto-oligosaccharides (200 mg), lactose (60 mg) and maltose (140 mg) were mixed and granulated with a fluid bed drier. After adding the sugar ester (6 mg), the resulting composition (500 mg) was tableted by a usual method.

Embodiment 3

[0060] [Dosage Form Example 3] Drink

[0061] Mix coumestrol (80mg), vitamin E (9mg), vitamin C (9mg), glucose (10g), citric acid (0.6g) and oligosaccharide syrup (25g). After adding purified water (300 mL), 200 mL of the resulting mixture was bottled. Then, it is sterilized at 130oC for 4-5 seconds to make a drink.

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PUM

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Abstract

The present invention relates to a composition for activating mitochondria, comprising, as an active ingredient, coumestrol, or a bean extract containing coumestrol.

Description

technical field [0001] The present invention relates to a method for activating mitochondria ( Mitochondria )Compositions. Background technique [0002] Mitochondria are organelles found in most eukaryotic cells and have their own mitochondrial DNA, distinct from nuclear DNA ( mtDNA ). The main function of mitochondria is to generate adenosine triphosphate (ATP), which is used as an energy source for cells. ATP is made using NADH and FADH produced within the mitochondrial matrix 2 , produced from the electron transport chain through the TCA cycle (tricarboxylic acid cycle). Therefore, the ATP produced will be used in various biosynthetic and metabolic processes requiring energy. [0003] In addition, mitochondria store calcium ions in the matrix, which are important for intracellular signaling, and provide them to the cytoplasm. Further, they are known to play central roles in apoptosis, cell proliferation and cell metabolism. [0004] Unlike nuclear DNA, since the m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61P25/00A61P19/00A61P27/02
CPCA23L1/0029A61K36/48A23L1/302A23L1/30A61K31/37A23L1/0026A61K31/35A23L2/52A23L1/3002A61K9/0095A23L33/10A23L33/105A23L33/15A23P10/28A23P10/30A61P1/16A61P3/04A61P3/06A61P9/00A61P9/04A61P9/12A61P19/00A61P25/00A61P25/28A61P27/02A61P39/00A61K36/484
Inventor 田熙英曺始永郑炫禹徐大方李尚骏
Owner AMOREPACIFIC CORP
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