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Heterocyclic aromatic ether compounds and synthesis method thereof

A technology of a heterocyclic aromatic ether and a synthesis method, which is applied in the direction of organic chemistry and the like, can solve the problems of complex synthesis process and high cost, and achieve the effect of safe and easy operation.

Inactive Publication Date: 2019-09-06
HENAN POLYTECHNIC UNIV
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Problems solved by technology

[0013] At present, there are many synthetic methods for aromatic ether compounds, but the defects of complex synthesis process and relatively high cost generally exist, and there is no relevant report on the method of synthesizing heterocyclic aromatic ether compounds through one-step reaction

Method used

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  • Heterocyclic aromatic ether compounds and synthesis method thereof
  • Heterocyclic aromatic ether compounds and synthesis method thereof
  • Heterocyclic aromatic ether compounds and synthesis method thereof

Examples

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Embodiment

[0038] Synthesis of Trivalent Iodine Oxidant

[0039]

[0040] Aromatic iodine compounds (1, 2 or 3) (1 g) were dissolved in a mixed solution of acetic acid (3 mL) and acetic anhydride (3 mL), and sodium perborate ( 10 times the molar weight of the aromatic iodine compound), keep the temperature constant until the raw material disappears completely, about 4-6 hours, cool down to room temperature and add water (20mL), the mixture precipitates a white solid, and the solid is obtained by filtration, and the filtrate is then washed with ethyl acetate Esters (20mL) were extracted 3 times, the organic phase was collected and washed with anhydrous MgSO 4 Dry, concentrate under reduced pressure to obtain white solid and mix with the solid obtained by previous filtration, the crude product is washed with a mixed solution of acetone and sherwood oil with a volume ratio of 1:1 to obtain white solid pure product (4, 5 or 6), corresponding to The rates were 91%, 86%, and 88%.

[0041]...

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Abstract

The invention discloses a heterocyclic ring aromatic ether compound and a synthesis method thereof, and belongs to the technical field of organic synthesis. The heterocyclic ring aromatic ether compound is mainly characterized in that the heterocyclic ring aromatic ether compound has the following structure general formula shown as the accompanying drawing, wherein R1 and R2 are correspondingly and respectively shown as follows: (1) R1 H, and R2 is H; (2) R1 is H, and R2 is Me; (3) R1 is Me, and R2 H. The invention concretely discloses the synthesis method of the heterocyclic ring aromatic ether compound. A mixed solution of acetic anhydride and acetic acid is used for replacing peroxyacetic acid or trifluoromethanesulfonic acid with high corrosiveness; the operation is safer and easier; the industrial production is facilitated; in addition, the heterocyclic ring aromatic ether compound is obtained through oxidizing 4-pyridone by iodonium oxidizing agents.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a heterocyclic aromatic ether compound and a synthesis method thereof. Background technique [0002] Present typical method for synthesizing trivalent iodine oxidizing agent: [0003] 1, synthesize trivalent iodine oxidant (document 1-3) with peroxyacetic acid oxidation iodine benzene compound, concrete reaction process is: [0004] [0005] 2, in the presence of trifluoromethanesulfonic acid, the trivalent iodine oxidant (document 4) is synthesized with sodium perborate oxidation iodobenzene compounds, and the concrete reaction process is: [0006] [0007] Although the above-mentioned method for synthesizing trivalent iodine oxidant is very effective, strong corrosive acid peracetic acid or trifluoromethanesulfonic acid is used in the synthesis process, and there are potential safety hazards in the operation process, which is not conducive to indust...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D213/68C07C71/00
Inventor 周德军孔继川李雪雁王振辉
Owner HENAN POLYTECHNIC UNIV
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