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Drugs and compositions for preventing and treating hippocampal head ulcer disease

A composition and drug technology, applied in the direction of drug combination, antibacterial drugs, skin diseases, etc., can solve the problems affecting hippocampus health and disease resistance, bacterial drug resistance, harm, etc., to achieve good synergistic effect, increase effective synergistic effect

Inactive Publication Date: 2020-01-31
HAINAN TROPICAL OCEAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Hippocampal head ulcer disease is a disease caused by Vibrio vulnificus. At present, the treatment method for hippocampal head ulcer disease is mainly to use antibiotics, combined with other drugs, such as oxytetracycline and povidone Ketone iodine, etc., and long-term use of antibiotics will not only make bacteria resistant, but also affect the health and disease resistance of the hippocampus; drug residues will not only harm the environment, but also cause serious social problems

Method used

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  • Drugs and compositions for preventing and treating hippocampal head ulcer disease
  • Drugs and compositions for preventing and treating hippocampal head ulcer disease
  • Drugs and compositions for preventing and treating hippocampal head ulcer disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] At present, commonly used antibiotics or substances with antibacterial function are used for the inhibition zone experiment of Vibrio vulnificus. The volume of the drug used in the experiment was 50 μL. Some experimental results are shown in Table 1-2:

[0062] Table 1 The effect of commonly used antibiotics against Vibrio vulnificus

[0063]

[0064]

[0065] Note: S, sensitive; I, intermediate; R, resistant.

[0066] Table 2 The diameter of the inhibition zone of commonly used active substances (mm)

[0067]

[0068] The results showed that polylysine, tea polyphenols, gallic acid, allicin and lactic acid had the effect of inhibiting Vibrio vulnificus. Under the condition of equal concentration, the effect was equivalent to or even better than that of commonly used antibiotics. However, other common active substances with antibacterial function did not show antibacterial effect.

Embodiment 2

[0070] Prepare the composition according to Table 3:

[0071] Table 3: Composition formulation

[0072] serial number Tea polyphenols (mg) Lactic acid (mg) Allicin (mg) Polylysine (mg) Gallic acid (mg) 1 27.5 45 20 60 10 2 27.5 10 20 60 10 3 5 45 20 60 10 4 50 10 10 20 10 5 27.5 80 20 60 10 6 27.5 45 20 60 10 7 50 80 30 20 10 8 5 10 30 20 10 9 5 10 30 100 10 10 50 45 20 60 10 11 27.5 45 20 60 10 12 27.5 45 20 60 10 13 50 10 30 20 10 14 50 80 10 100 10 15 50 80 30 100 10 16 50 10 30 100 10 17 27.5 45 10 60 10 18 5 80 30 20 10 19 27.5 45 20 100 10 20 50 80 10 20 10 21 5 80 30 100 10 22 5 10 10 100 10 23 27.5 45 20 60 10 24 27.5 45 20 60 10 25 5 80 10 100 10 26 50 10 10 100 10 27 27.5 45 20 20 10 28 5 10 10 20 10 ...

Embodiment 3

[0078] Take healthy seahorses and put them into the hippocampal head ulceration pathogenic bacteria (Vibrio vulnificus DC1) at a concentration of 1×10 6 After soaking in 20L water of cfu / mL for 12 hours, they were moved into glass tanks with an effective water body of 70cm×50cm×50cm for normal feeding and water change, and continuous observation for 30 days.

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Abstract

The invention relates to the technical field of aquaculture and particularly relates to a drug for preventing and treating hippocampal head ulcer and its composition. The composition is composed of active substances for inhibiting vibrio vulnificus. An in-vitro experiment result shows that the active substances such as tea polyphenol, gallic acid, allicin, lactic acid and polylysine can inhibit vibrio vulnificus, an inhibitory zone diameter is the same to that of most of common antibiotics and resistance to drugs does not exist. An experimental result shows that five components of the composition produce good synergism, and under the same use amount, the composition has an inhibitory zone diameter greater than that of a single component (p<0.05). The drug utilizes natural edible medicinal components, can be completely metabolized by the hippocampus, prevents drug residues, has no toxic or side effect, does not cause resistance to drugs and does not pollute the hippocampus aquaculture water environment.

Description

technical field [0001] 本发明涉及水产养殖技术领域,尤其涉及防治海马头部溃烂病的药物及组合物。 Background technique [0002] 海马为海龙科动物是刺鱼目海龙科暖海生数种小型鱼类的统称。海马作为一种名贵的中药材,在我国使用的历史悠久,早在《本草纲目》等多部医药著作中就有记载。海马因具有极高的药用和营养价值,享有“南方人参”之美誉,具有温肾壮阳、消肿散节和妇人催生等功效。 [0003] 目前在热带和温带沿海的海草床、珊瑚礁、红树林和河口地区发现至少46个种的海马。2012年,世界自然保护联盟(IUCN)将38种海马列入濒危物种。作为缔约国,我国也已将海马列为国家二级保护动物。为了拯救海马这一濒危物种,并满足市场需求,除建立海马自然保护区,改善海马生存环境来保护海马自然资源外,通过人工养殖海马是海马保护的重要手段之一。我国自1957年以来已经开始养殖海马,然而目前海马养殖产业在国内推广并不是很好,限制其发展的主要瓶颈是养殖技术和病害。 [0004] 海马养殖中,水质、水温、光线、比重及饵料等环境因子变化往往较大,海马由于不能适应这种环境的变化,病害发生较多,死亡率较高。据调查,海南省琼海市某海马种苗繁育基地,从2016年5月~8月,约30个养殖池几乎全部死亡,给该养殖基地造成巨大的损失。在同一时期,广东和福建沿海的养殖户也出现大面积死亡,死亡率高达80%~90%。而引起海马大规模死亡的重要原因之一是海马的头部溃烂病。 [0005] 海马头部溃烂病是由创伤弧菌(Vibrio vulnificus)导致的疾病,目前,针对海马的头部溃烂病的治疗方法还是以使用抗生素类药物为主,结合其他药物,如土霉素和聚维酮碘等,而长期使用抗生素类药物不但会使细菌产生抗药性,而且会影响海马健康和抗病害能力;药物残留不但会对环境产生危害,而且会产生严重的社会问题。近年来,从天然植物特别是药用植物中寻找纯天然抗生物药物已成为研究热点。 Contents of the invention [0006] 有鉴于此,本发明要解决的技术问题在于提供防治海马头部溃烂病的药物及组合物。本发明提供的活性物质或组合物能够通过抑制创伤弧菌达到防治海马头部溃烂病的作用。 [0007] 本发明提供了活性物质在制备抑制创伤弧...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/785A61K31/353A61K31/192A61K31/19A61K31/255A61P17/02A61P31/04A01K61/13A23K50/80A23K20/121A23K20/111A23K20/142A23K20/10
CPCA01K61/00A61K31/19A61K31/192A61K31/255A61K31/353A61K31/785A61K2300/00Y02A40/81
Inventor 姜芳燕杨宁徐小雄冯慧敏黄海武耀廷
Owner HAINAN TROPICAL OCEAN UNIV
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