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Drug for preventing and treating hippocampal head ulcer and its composition

A composition and drug technology, applied in the direction of drug combination, skin diseases, antibacterial drugs, etc., can solve the problems affecting hippocampus health and disease resistance, bacterial drug resistance, drug residual environment, etc., and achieve good synergistic effect , Synergistic and synergistic effect

Inactive Publication Date: 2017-07-28
HAINAN TROPICAL OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Hippocampal head ulcer disease is a disease caused by Vibrio vulnificus. At present, the treatment method for hippocampal head ulcer disease is mainly to use antibiotics, combined with other drugs, such as oxytetracycline and povidone Ketone iodine, etc., and long-term use of antibiotics will not only make bacteria resistant, but also affect the health and disease resistance of the hippocampus; drug residues will not only harm the environment, but also cause serious social problems

Method used

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  • Drug for preventing and treating hippocampal head ulcer and its composition
  • Drug for preventing and treating hippocampal head ulcer and its composition
  • Drug for preventing and treating hippocampal head ulcer and its composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] At present, commonly used antibiotics or substances with antibacterial function are used for the inhibition zone experiment of Vibrio vulnificus. The volume of the drug used in the experiment was 50 μL. Some experimental results are shown in Table 1-2:

[0062] Table 1 The effect of commonly used antibiotics against Vibrio vulnificus

[0063]

[0064]

[0065] Note: S, sensitive; I, intermediate; R, resistant.

[0066] Table 2 The diameter of the inhibition zone of commonly used active substances (mm)

[0067]

[0068] The results showed that polylysine, tea polyphenols, gallic acid, allicin and lactic acid had the effect of inhibiting Vibrio vulnificus. Under the condition of equal concentration, the effect was equivalent to or even better than that of commonly used antibiotics. However, other common active substances with antibacterial function did not show antibacterial effect.

Embodiment 2

[0070] Prepare the composition according to Table 3:

[0071] Table 3: Composition formulation

[0072] serial number Tea polyphenols (mg) Lactic acid (mg) Allicin (mg) Polylysine (mg) Gallic acid (mg) 1 27.5 45 20 60 10 2 27.5 10 20 60 10 3 5 45 20 60 10 4 50 10 10 20 10 5 27.5 80 20 60 10 6 27.5 45 20 60 10 7 50 80 30 20 10 8 5 10 30 20 10 9 5 10 30 100 10 10 50 45 20 60 10 11 27.5 45 20 60 10 12 27.5 45 20 60 10 13 50 10 30 20 10 14 50 80 10 100 10 15 50 80 30 100 10 16 50 10 30 100 10 17 27.5 45 10 60 10 18 5 80 30 20 10 19 27.5 45 20 100 10 20 50 80 10 20 10 21 5 80 30 100 10 22 5 10 10 100 10 23 27.5 45 20 60 10 24 27.5 45 20 60 10 25 5 80 10 100 10 26 50 10 10 100 10 27 27.5 45 20 20 10 28 5 10 10 20 10 ...

Embodiment 3

[0078] Take healthy seahorses and put them into the hippocampal head ulceration pathogenic bacteria (Vibrio vulnificus DC1) at a concentration of 1×10 6 After soaking in 20L water of cfu / mL for 12 hours, they were moved into glass tanks with an effective water body of 70cm×50cm×50cm for normal feeding and water change, and continuous observation for 30 days.

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Abstract

The invention relates to the technical field of aquaculture and particularly relates to a drug for preventing and treating hippocampal head ulcer and its composition. The composition is composed of active substances for inhibiting vibrio vulnificus. An in-vitro experiment result shows that the active substances such as tea polyphenol, gallic acid, allicin, lactic acid and polylysine can inhibit vibrio vulnificus, an inhibitory zone diameter is the same to that of most of common antibiotics and resistance to drugs does not exist. An experimental result shows that five components of the composition produce good synergism, and under the same use amount, the composition has an inhibitory zone diameter greater than that of a single component (p<0.05). The drug utilizes natural edible medicinal components, can be completely metabolized by the hippocampus, prevents drug residues, has no toxic or side effect, does not cause resistance to drugs and does not pollute the hippocampus aquaculture water environment.

Description

technical field [0001] The invention relates to the technical field of aquaculture, in particular to medicines and compositions for preventing and treating hippocampus head ulcer disease. Background technique [0002] The seahorse is a sea dragon family animal, which is a collective name for several small fishes living in the warm sea of ​​the sea dragon family. As a precious Chinese medicinal material, hippocampus has a long history of use in my country, and it has been recorded in many medical works such as "Compendium of Materia Medica". Hippocampus enjoys the reputation of "Southern Ginseng" because of its extremely high medicinal and nutritional value. [0003] At least 46 species of seahorses are currently found in tropical and temperate coastal seagrass beds, coral reefs, mangroves, and estuaries. In 2012, the International Union for Conservation of Nature (IUCN) listed 38 species of seahorses as endangered. As a contracting party, my country has also listed the se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/785A61K31/353A61K31/192A61K31/19A61K31/255A61P17/02A61P31/04A01K61/13A23K50/80A23K20/121A23K20/111A23K20/142A23K20/10
CPCA01K61/00A61K31/19A61K31/192A61K31/255A61K31/353A61K31/785A61K2300/00Y02A40/81
Inventor 姜芳燕杨宁徐小雄冯慧敏黄海武耀廷
Owner HAINAN TROPICAL OCEAN UNIV
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