Quantitative calculation method for automatic regional brain shrinkage degree

A quantitative calculation and brain atrophy technology, applied in computing, image analysis, image data processing, etc., can solve the problem of lack of quantitative methods for the degree of brain atrophy, and achieve the effect of high degree of quantification, accurate judgment and high feasibility

Active Publication Date: 2017-08-29
SHENZHEN BRAINNOW MEDICAL TECH CO LTD
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Problems solved by technology

[0006] The purpose of the present invention is to provide an automatic quantitative calculation method for the degree of

Method used

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  • Quantitative calculation method for automatic regional brain shrinkage degree
  • Quantitative calculation method for automatic regional brain shrinkage degree
  • Quantitative calculation method for automatic regional brain shrinkage degree

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Experimental program
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Embodiment

[0045] Collect the T1w structural magnetic resonance images of 100 normal elderly people aged 65±9 years old and 100 dementia patients aged 65±9 years old for experiments, and compare the brain regions of normal elderly people and dementia patients Atrophy of the brain. Specific steps are as follows:

[0046] Step S01. Perform non-linear registration and mapping between the T1w structural magnetic resonance images of normal elderly people and senile dementia patients and brain templates to obtain the space between each brain template and each individual (normal elderly people, senile dementia patients) transformation relationship;

[0047] Step S02. Map the brain lobe partition and brain tissue probability map on the brain template to the object space to be segmented;

[0048] Step S03. Use the STAPLE label fusion method to fuse the brain lobe partitions of each individual; select the brain tissue probability map of the template that is most similar to the target image after...

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Abstract

The invention relates to the computation technology field for brain shrinkage degree, and more particularly to a quantitative calculation method for automatic regional brain shrinkage degree. The quantitative calculation method comprises at least the steps of brain template library creating, non-linear registration mapping and brain shrinkage degree calculation. The quantitative calculation method is convenient, rapid and highly quantitative. With the method, it is possible to find a highly feasible scheme for quantitative brain shrinkage degree so as to provide reference to other judgments based on the brain shrinkage degree.

Description

technical field [0001] The invention relates to the technical field of calculation of brain atrophy degree, in particular to an automatic quantitative calculation method of regional brain atrophy degree. Background technique [0002] Brain atrophy is a phenomenon in which the brain tissue itself shrinks due to organic lesions. The main pathological manifestations of brain atrophy are shrinkage of brain tissue structure, reduction of brain parenchyma, reduction of brain weight, reduction of cell number, flattening of brain gyri, widening and deepening of brain sulci, and enlargement of ventricles, brain cisterns and subarachnoid space. The clinical manifestations of brain atrophy can be divided into two categories: brain function decline and mental decline such as dementia, which are mainly related to the location and degree of brain atrophy. Among them, an important type of brain atrophy is brain atrophy with cerebral cortex atrophy as the main pathological change, which is...

Claims

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Application Information

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IPC IPC(8): G06T7/143G06T7/11
CPCG06T2207/10088G06T2207/30016G06T7/11
Inventor 罗怡珊
Owner SHENZHEN BRAINNOW MEDICAL TECH CO LTD
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