The invention relates to a three-dimensional nonlinear registration method and
system for a massive brain image
data set. The three-dimensional nonlinear registration method of the massive brain imagedata set includes the following steps of: S0, down-sampling; S1, low-resolution
image registration; and S2, high-resolution image fast transformation. The low-resolution
image registration step further includes the following steps of S11, linear registration; and S12, nonlinear registration. The high-resolution image fast transformation step further includes the following steps of: S21,
transformation matrix calculation for high-resolution registration; S22, post-high-resolution registration spatial range calculation; S23, blocking; and S24, high-resolution
nonlinear transformation. Accordingto the three-dimensional nonlinear registration method and
system for the massive brain image
data set of the invention, the registration information of low-resolution image data is adopted to transform the massive high-resolution three-dimensional image
data set, so that the nonlinear registration of the massive high-resolution three-dimensional image data set can be realized. The method and
system of the invention are applicable to all linear registration based on transformation matrices and all nonlinear registration based on displacement fields and can quickly perform nonlinear registration on TB-
level data sets.