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Tea polyphenol effervescent tablets and preparing method thereof

A technology for tea polyphenols and effervescent tablets, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problem of long onset time and limited bioavailability of medicinal value of traditional Chinese medicine , slow disintegration speed and other problems, to achieve the effect of improving use performance, conducive to dissolution and absorption, and good health care effect

Active Publication Date: 2017-09-08
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex composition of traditional Chinese medicine raw materials, most of them have problems such as slow disintegration speed and long onset time after making preparations, which limit the medicinal value and bioavailability of traditional Chinese medicine.

Method used

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Examples

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Effect test

preparation example Construction

[0037] The present invention also provides a preparation method for the above-mentioned tea polyphenol effervescent tablet, comprising the following steps:

[0038] Firstly, the materials used are crushed. The tea polyphenols, citric acid, sodium bicarbonate and soluble starch are pulverized respectively. In the present invention, there is no special limitation on the pulverization method, and the pulverization method well known to those skilled in the art can be used for pulverization. The crushed material is sieved for the preparation of acid granules and alkali granules. In the specific embodiment of the present invention, it is preferable that the pulverized materials pass through a No. 7 sieve, so that the materials can be mixed more evenly.

[0039] The crushed material is used to prepare acid granules and alkali granules respectively.

[0040] The preparation method of acid particles is as follows:

[0041] 1-3 parts by weight of pulverized citric acid and 1-3 parts...

Embodiment 1

[0051] Prepare tea polyphenol effervescent tablet according to the following formula:

[0052] Acid granules: 10g tea polyphenols, 2g citric acid, 2g soluble starch, use 90% ethanol as binder; alkali granules: 10g tea polyphenols, 2g sodium bicarbonate, 2g soluble starch, use 5% PVP anhydrous Ethanol solution is used as a binder; PEG6000 is used as a lubricant, and the amount added is 0.60 g.

[0053] Grind tea polyphenols, citric acid, sodium bicarbonate and soluble starch respectively, and pass through a No. 7 sieve. Baking the pulverized soluble starch at 88° C. for 55 minutes to remove moisture.

[0054] Take 2g of crushed citric acid and 2g of soluble starch, mix evenly, then add 10g of tea polyphenol powder according to the doubling method, mix evenly, add 8mL of 90% ethanol to make a soft material, granulate with a granulator, and dry at 40°C , Whole grains, prepared acid grains for later use.

[0055] Take 2g of crushed sodium bicarbonate and 2g of soluble starch, m...

Embodiment 2

[0058] Prepare tea polyphenol effervescent tablet according to the following formula:

[0059] Acid granules: 12g tea polyphenols, 3g citric acid, 3g soluble starch, use 98% ethanol as binder; base granules: 12g tea polyphenols, 3g sodium bicarbonate, 3g soluble starch, use 3% PVP anhydrous Ethanol solution is used as a binder; PEG6000 is used as a lubricant, and the amount added is 0.7g.

[0060] Grind tea polyphenols, citric acid, sodium bicarbonate and soluble starch respectively, and pass through a No. 7 sieve. Dry the pulverized soluble starch at 100°C for 35 minutes to remove moisture.

[0061] Take 3g of crushed citric acid and 3g of soluble starch, mix evenly, then add 12g of tea polyphenol powder according to the multiplication method, mix evenly, add 9mL of 98% ethanol to make a soft material, granulate with a granulator, and dry at 60°C , Whole grains, prepared acid grains for later use.

[0062] Take 3g of crushed sodium bicarbonate and 3g of soluble starch, mix...

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PUM

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Abstract

The invention relates to the technical field of effervescent tablet preparation, and discloses tea polyphenol effervescent tablets. The tea polyphenol effervescent tablets are composed of acid granules, alkaline granules and a lubricant, wherein the acid granules comprise, by weight, 8-12 parts of tea polyphenols, 1-3 parts of citric acid and 1-3 parts of soluble starch, and further comprises, by volume, 6-9 parts of ethyl alcohol serving as a binding agent, the alkaline granules comprise, by weight, 8-12 parts of tea polyphenols, 1-3 parts of sodium bicarbonate and 1-3 parts of soluble starch, and further comprises, by volume, 5-8 parts of PVP absolute ethyl alcohol solution serving as a binding agent, and the lubricant comprises, by weight, 0.50-0.70 part of PEG6000. The invention further comprises a preparing method of the tea polyphenol effervescent tablets. The prepared tea polyphenol effervescent tablets can be quickly disintegrated in water, effective components are released, which is beneficial to sufficient dissolution and absorption of tea polyphenols, and the healthcare effect is good. The prepared tea polyphenol effervescent tablets are small in size, light in weight and convenient to carry and use, and thus the using performance of the tea polyphenol effervescent tablets is sharply improved.

Description

technical field [0001] The invention relates to the technical field of making effervescent tablets, in particular to a tea polyphenol effervescent tablet and a preparation method thereof. Background technique [0002] Tea Polyphenols (Tea Polyphenols) is the general term for polyphenols in tea, which has good anti-radiation, cancer prevention, anti-aging, and antibacterial and bactericidal health effects. Effervescent tablet is a novel tablet developed and applied abroad in recent years. It differs from ordinary tablets in that it also contains an effervescent disintegrant. When the effervescent tablet is put into drinking water, under the action of the effervescent disintegrant, a large number of bubbles (carbon dioxide) will be generated immediately, making the Tablets disintegrate and melt quickly. The carbon dioxide produced when the tablet disintegrates is partially dissolved in water, so that the resulting solution has a soda-like aesthetic feeling when drunk in the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K31/353A61K36/82A61K47/12A61K47/02A61P17/18A61P39/00A61P35/00A61P39/06A61P31/04A61P31/10A61K9/16
CPCA61K9/0007A61K9/1611A61K9/1617A61K9/1652A61K9/2077A61K31/353A61K36/82
Inventor 梁俊玉张雨蔚王思敏王兴新凌文瑞王俊龙孔维宝张继
Owner NORTHWEST NORMAL UNIVERSITY
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