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Diagnosis tool for primary osteoporosis for postmenopausal women

A technology for primary osteoporosis, applied in the field of diagnosis, which can solve the problems of small number of equipment, high price, and large economic burden for osteoporosis patients

Inactive Publication Date: 2017-09-15
BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is currently only used for the calcaneus, tibia and phalanges, and cannot detect the whole body bones
[0016] Dual-energy X-ray absorptiometry: It is the most ideal measurement method at present, and it is the gold standard for diagnosing osteoporosis. Expensive and therefore financially burdensome for diagnosis in osteoporosis patients

Method used

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  • Diagnosis tool for primary osteoporosis for postmenopausal women
  • Diagnosis tool for primary osteoporosis for postmenopausal women

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1 Screening of genes differentially expressed in postmenopausal women with primary osteoporosis and normal menopausal women

[0055] 1. Research object:

[0056] Three postmenopausal women with primary osteoporosis, aged 81, 68, and 79 years old, and two normal postmenopausal women, aged 67 and 68, were selected.

[0057] Inclusion criteria for postmenopausal women with primary osteoporosis: Han postmenopausal women who have menopause for more than 12 months, and all patients have informed consent;

[0058] Exclusion criteria for patients with primary osteoporosis in postmenopausal women include ① Previously received anti-resorptive drugs (including calcitonin, bisphosphonates, estrogen, etc.) or bone-promoting drugs (such as parathyroid hormone, etc.) Treatment (except for those who simply use calcium and / or vitamin D); ② long-term use of glucocorticoids; ③ combined with malignant tumors, bone metastases, and other endocrine and bone metabolism history (such a...

Embodiment 2

[0087] Example 2 QPCR experiment verification of genes differentially expressed in postmenopausal women with primary osteoporosis and normal menopausal women

[0088] 1. Research object:

[0089] Select 30 postmenopausal women with primary osteoporosis and 30 normal postmenopausal women, aged 65-82 years.

[0090] Inclusion criteria for postmenopausal women with primary osteoporosis: Han postmenopausal women who have menopause for more than 12 months, and all patients have informed consent;

[0091] Exclusion criteria for patients with primary osteoporosis in postmenopausal women include ① Previously received anti-resorptive drugs (including calcitonin, bisphosphonates, estrogen, etc.) or bone-promoting drugs (such as parathyroid hormone, etc.) Treatment (except for those who simply use calcium and / or vitamin D); ② long-term use of glucocorticoids; ③ combined with malignant tumors, bone metastases, and other endocrine and bone metabolism history (such as rheumatoid arthritis,...

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Abstract

The invention discloses a diagnosis tool for primary osteoporosis for postmenopausal women. The diagnosis tool achieves a diagnosis purpose by detecting DHRS12 gene and its expression product in blood. The research proves that compared with normal postmenopausal women, the mRNA expression level of the DHRS12 gene in the patient blood with primary osteoporosis for the postmenopausal women is obviously decreased. According to the correlation existed between the DHRS12 gene and the primary osteoporosis for the postmenopausal women, a kit for diagnosing the primary osteoporosis for the postmenopausal women is prepared, and the kit can be widely used for clinic application.

Description

technical field [0001] The invention belongs to the field of diagnosis, relates to a diagnostic tool for primary osteoporosis in postmenopausal women, and also relates to the application of DHRS12 gene in blood in preparing the diagnostic tool for primary osteoporosis in postmenopausal women. Background technique [0002] Osteoporosis (OP) is a systemic bone disease characterized by low bone mass, destruction of bone microarchitecture, increased bone fragility, and susceptibility to fracture (WHO). In 2001, the National Institutes of Health (NIH) of the United States proposed that osteoporosis is a disease of the skeletal system characterized by decreased bone strength and increased risk of fracture. Bone strength reflects two main aspects of bones, namely bone mineral density and bone quality. . [0003] The disease can occur in different genders and at any age, but it is more common in postmenopausal women and older men. Osteoporosis is divided into primary and secondary...

Claims

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Application Information

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IPC IPC(8): C12Q1/68G01N33/68
CPCC12Q1/6883C12Q2600/158G01N33/6893G01N2800/108
Inventor 费琦杨雍林吉生
Owner BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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