Use of piRNAs as prognostic markers in diffuse large B-cell lymphoma
A diffuse, B-cell technology, applied in the field of life sciences, which can solve the problems of inability to predict the prognosis of patients and ignoring the heterogeneity of molecular biology.
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[0024] The application of piRNA in the treatment of diffuse large B-cell lymphoma, the piRNA is used as a marker for the prognosis of diffuse large B-cell lymphoma, and the type of piRNA is piRNA-42435 or piRNA-30374.
[0025] The verification method of the present invention detects the differential expression of piRNAs in paraffin-embedded tissues of 6 DLBCL patients by microarray, and finds that the expression levels of piRNA-42435, piRNA-30374 and piRNA30222 in DLBCL cases with poor prognosis are significantly higher than those in DLBCL with good prognosis Therefore, it can be speculated that the expression levels of piRNA-42435, piRNA-30374 and piRNA30222 are related to the prognosis of DLBCL patients.
[0026] In order to further prove the above conjecture, the verification method of the present invention detected the expression levels of piRNA-42435, piRNA-30374 and piRNA30222 in paraffin-embedded tissues of 42 cases of DLBCL patients. The patients were divided into two ...
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