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Use of piRNAs as prognostic markers in diffuse large B-cell lymphoma

A diffuse, B-cell technology, applied in the field of life sciences, which can solve the problems of inability to predict the prognosis of patients and ignoring the heterogeneity of molecular biology.

Active Publication Date: 2020-12-04
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it still needs to be pointed out that the IPI index only includes some clinical indicators, but ignores the heterogeneity of molecular biology reflecting DLBCL, so the IPI index still cannot accurately and effectively predict the prognosis of a considerable number of patients

Method used

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  • Use of piRNAs as prognostic markers in diffuse large B-cell lymphoma
  • Use of piRNAs as prognostic markers in diffuse large B-cell lymphoma
  • Use of piRNAs as prognostic markers in diffuse large B-cell lymphoma

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Embodiment Construction

[0024] The application of piRNA in the treatment of diffuse large B-cell lymphoma, the piRNA is used as a marker for the prognosis of diffuse large B-cell lymphoma, and the type of piRNA is piRNA-42435 or piRNA-30374.

[0025] The verification method of the present invention detects the differential expression of piRNAs in paraffin-embedded tissues of 6 DLBCL patients by microarray, and finds that the expression levels of piRNA-42435, piRNA-30374 and piRNA30222 in DLBCL cases with poor prognosis are significantly higher than those in DLBCL with good prognosis Therefore, it can be speculated that the expression levels of piRNA-42435, piRNA-30374 and piRNA30222 are related to the prognosis of DLBCL patients.

[0026] In order to further prove the above conjecture, the verification method of the present invention detected the expression levels of piRNA-42435, piRNA-30374 and piRNA30222 in paraffin-embedded tissues of 42 cases of DLBCL patients. The patients were divided into two ...

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Abstract

The invention discloses application of piRNA to serving as a prognostic marker for diffuse large B cell lymphoma, wherein the specific type of piRNA is piRNA-42435 and piRNA-30374. The prognosis evaluation of a patient subjected to the diffuse large B cell lymphoma is conducted by detecting the expression levels of piRNA-42435 and piRNA-30374 of the patient, the unfavorable prognosis case is screened at the early stage, and the application helps to select the clinical treatment plan and improve the prognosis.

Description

technical field [0001] The invention belongs to the field of life sciences, and relates to the application of piRNA in the treatment of diffuse large B-cell lymphoma, specifically, the application of piRNA as a prognostic marker in diffuse large B-cell lymphoma in B-cell lymphoma. Background technique [0002] Diffuse large B-cell lymphoma (DLBCL) is a malignant lymphoma of B-cell origin, aggressive clinical manifestations, and requires high-efficiency chemotherapy. It is also the most common non-Hodgkin lymphoma Lymphoma (Non Hodgkin's lymphoma, NHL) accounts for about 40% of NHL. The cause of the disease is not yet clear, and the incidence rate is increasing year by year, and the occurrence of DLBCL is not limited by age. Clinically, it is most common in middle-aged and elderly patients, and the median age of onset is 70 years old. In Western countries, the incidence of DLBCL accounts for about 31% of the incidence of NHL, and the incidence of DLBCL in Asian countries is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 李炳宗庄文卓
Owner SUZHOU UNIV
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