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Soluble microneedle for delivering poorly-soluble drug

An insoluble and microneedle technology, which is applied in the direction of drug devices, microneedles, drug combinations, etc., can solve the problems of difficult absorption and large volume, and achieve the effect of reducing skin wrinkles

Active Publication Date: 2017-11-28
LG HOUSEHOLD & HEALTH CARE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large volume of particles and liposomes (tens to hundreds of nm or more than several μm), it is difficult to directly absorb into the skin only through skin application

Method used

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  • Soluble microneedle for delivering poorly-soluble drug
  • Soluble microneedle for delivering poorly-soluble drug
  • Soluble microneedle for delivering poorly-soluble drug

Examples

Experimental program
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Embodiment Construction

[0047] In order to facilitate understanding of the present invention, examples are given below in detail. However, various modifications can be made to the examples of the present invention, and the scope of the present invention is not limited to the following examples. The embodiments of the present invention are provided to more completely describe the present invention to those skilled in the art. Herein, unless otherwise specified, the content of the composition is expressed in % by weight.

[0048] Fabrication of Microneedles Containing Paeonol Microparticles

[0049]

[0050] As shown in Table 1 below, an oil in water dosage form with a paeonol content of 0.05% was manufactured.

[0051] Table 1

[0052]

[0053]

[0054] Paeonol ( Paeonol). First, a solution of 10 g of mPEG-PCL (5k-5k, 5k-10k mixed 1:1) dissolved in 40 mL of ethanol was mixed with a solution of 2 g of paeonol dissolved in 20 g of caprylic / capric triglyceride . The above-mentioned soluti...

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Abstract

The present invention relates to a system for administering a poorly-soluble compound to the skin, the system being capable of exerting an excellent effect by stably impregnating the poorly-soluble compound and effectively delivering the poorly-soluble compound into the skin, and the present invention is technically characterized by a microneedle to which microparticles comprising a poorly-soluble compound are added. In addition, the present invention provides a method for administering a poorly-soluble compound to the skin, the method being characterized by using the microneedle.

Description

technical field [0001] This application claims the benefit of Korean Patent Application 10-2015-0048454 filed on April 6, 2015, Korean Patent Application 10-2015-0151027 filed on October 29, 2015, Korean Patent Application filed on April 6, 2015 Patent application 10-2015-0048482, the priority of Korean patent application 10-2015-0151046 filed on October 29, 2015, is hereby incorporated by reference as if fully disclosed herein. [0002] The present invention relates to a soluble microneedle, a method for transdermally administering a poorly soluble compound using the soluble microneedle, and a method for manufacturing the soluble microneedle. Background technique [0003] As we all know, isoflavones have excellent effects in anti-oxidation, anti-bacterial, anti-cancer, inhibition of osteoporosis, regulation of fat metabolism, and lowering blood cholesterol. In addition, since isoflavones are also known to have skin anti-aging effects, various studies are being conducted to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/122A61K8/49A61K31/352A61K47/36A61K47/38A61K47/32A61K47/26A61K47/34A61M37/00A61K8/02A61K8/35A61P17/00A61Q19/08
CPCA61K8/02A61K8/35A61K8/49A61K9/0021A61K9/70A61K31/122A61K31/352A61K47/26A61K47/32A61K47/34A61K47/36A61K47/38A61M37/00A61Q19/08A61K2800/91A61K9/1641A61K9/1647A61K8/347A61K8/498A61K8/731A61K8/735A61K8/85A61K8/027A61K8/0275A61K2800/412A61M2037/0053A61P17/00A61P17/18A61K8/0208A61K9/7023A61M37/0015A61K2121/00A61K8/14A61K9/141
Inventor 沈愚先李鲜和黄英暋金贞雅姜来圭
Owner LG HOUSEHOLD & HEALTH CARE LTD