Methods of treating liver disease using indane acetic acid derivatives

A post-treatment, hepatitis C virus technology, applied in the direction of pharmaceutical formulas, drug combinations, medical preparations containing active ingredients, etc., can solve problems such as permanent damage to the liver, scars, liver cirrhosis, etc.

Inactive Publication Date: 2018-01-02
T3D THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, NASH can be serious and can lead to cirrhosis of the liver, in which the liver is permanently damaged and scarred, no longer able to function properly

Method used

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  • Methods of treating liver disease using indane acetic acid derivatives
  • Methods of treating liver disease using indane acetic acid derivatives
  • Methods of treating liver disease using indane acetic acid derivatives

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0235] [(1S)-5-Hydroxy-2,3-dihydro-1H-inden-1-yl]ethyl acetate

[0236]

[0237] Prepared from 5-methoxyindanone in six steps as described in US68283335.

example 2

[0239] 2-[5-Ethyl-2-(4-methoxyphenyl)-1,3-oxazol-4-yl]ethanol

[0240]

[0241] Prepared from L-aspartic acid β-methyl ester hydrochloride, 4-methoxybenzoyl chloride and propionic anhydride as generally described in US68283335.

example 3

[0243] 2-[2-(4-Methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]ethanol

[0244]

[0245] Prepared from L-aspartic acid β-methyl ester hydrochloride, 4-methoxybenzoyl chloride and acetic anhydride as generally described in US Patent 6,828,335.

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PUM

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Abstract

This invention describes the use of indane acetic acid derivatives which are dual PPAR delta / gamma agonists for the treatment of liver diseases including one or more of the following: NAFLD (Non Alcoholic Fatty Liver Disease), NASH (Non Alcoholic Steatohepatitis), Farber's Disease, ACLF (Acute-on-Chronic Liver Failure), CLF (Chronic Liver Failure), POLT-HCV-SVR (Post-Orthotopic Liver Transplantdue to Hepatitis C Virus infection after Sustained Viral Response following anti-HCV therapy), Alagille syndrome, PFIC (Progressive Familial Intrahepatic Cholestasis), PBC (Primary Biliary Cirrhosis),Primary Sclerosing Cholangitis, ADPCLD (Autosomal Dominant Polycystic Liver Disease), Treatment of liver transplant patients with reestablished fibrosis, CESD (Cholesteryl Ester Storage Disease), SHTG (Severe Hypertriglyceridemia), HoFH (Homozygous Familial Hypercholesterolemia), HE (Hepatic Encephalopathy), or Alcoholic Liver Disease.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application No. 62 / 138,698, filed March 26, 2015, which is incorporated by reference in its entirety. [0003] Copyright Notice [0004] Portions of the disclosure of this patent contain copyrighted material. The copyright owner has no objection to the reproduction by anyone of any patent document or patent disclosure, as it appears in the Patent and Trademark Office patent file or records, but otherwise reserves all copyrights. technical field [0005] The present invention relates to the use of indane acetic acid and derivatives thereof as dual PPARδ and γ agonists in the treatment of the following liver diseases: NAFLD (nonalcoholic fatty liver disease), NASH (nonalcoholic steatohepatitis), Farber disease, ACLF ( Acute-on-chronic liver failure), CLF (chronic liver failure), POLT-HCV-SVR (orthotopic liver transplantation after hepatitis C virus infection after sus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/535
CPCA61K31/426A61K31/421A61P1/16A61K45/06
Inventor 约翰·罗伯特·迪兹伯里
Owner T3D THERAPEUTICS INC
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