Application of sarpogrelate containing pharmaceutical composition in treatment of diabetic nephropathy
A kind of sarpogrelate, drug technology, applied in the field of medicine
Inactive Publication Date: 2018-04-20
CHINA PHARM UNIV
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- Description
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- Application Information
AI Technical Summary
Problems solved by technology
[0011] At present, there is no report on the combined use of sarcogrelate and / or serotonin synthesis inhibitors for the treatment of diabetic nephropathy
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0163] 1 part by weight of sagrester, 5 parts by weight of p-chlorophenylalanine, and dextrin and other commonly used adjuvants for granules are prepared into granules by conventional technology.
Embodiment 2
[0165] 1 part by weight of sagrester, 2 parts by weight of p-chlorophenylalanine, and microcrystalline cellulose and other commonly used auxiliary materials for tablets are compressed into tablets.
Embodiment 3
[0167] 2 parts by weight of sagrellate, 1 part by weight of p-chlorophenylalanine, and dextrin and other commonly used adjuvants for granules are used to make granules by conventional technology, and then poured into hard capsule skins to make capsules.
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The invention belongs to the technical field of pharmaceuticals, discloses application of a sarpogrelate containing pharmaceutical composition in treatment of diabetic nephropathy, and specifically discloses the application of a compound pharmaceutical composition taking sarpogrelate and 5-hydroxytryptamine synthesizing inhibitor as pharmaceutical active components in preparation of drugs for treating diabetic nephropathy. The test shows that gene silencing 5-HT synthetase and a 5-HT 2 receptor show good effect on inhibiting in-vitro culture and high glucose-induced oxidative stress of human renal mesangial cell strain, proinflammatory factor and chemotactic factor, and meanwhile, the gene silencing 5-HT synthetase system (Tph1 or AADC) and a 5HT 2 receptor are capable of greatly inhibiting high glucose-inducing effect and performing synergistic effect. With the adoption of the pharmaceutical composition, the diabetic nephropathy caused by high-fat feed feeding and streptozotocin induced diabetic nephropathy can be obviously treated; compared with simple prescription, the compound prescription is high in attenuation, and the lethal amount of mice orally taking the drug is obviouslyhalved.
Description
technical field [0001] The invention belongs to the field of medicine, and relates to the use of a pharmaceutical composition containing sagrelor for treating diabetic nephropathy, in particular to a compound drug combination of a serotonin 2 receptor antagonist sagrelate and a 5-serotonin synthesis inhibitor Drugs for the treatment of diabetic nephropathy purposes. Background technique [0002] Diabetic nephropathy (DN) is the most serious complication of diabetes. In recent years, the number of patients worldwide has been increasing, and it has become one of the main causes of end-stage renal disease. The pathogenesis of DN is complex and has not been fully understood so far. At present, it is believed that it is mainly related to metabolic disorders (hyperglycemia, hyperlipidemia, etc.) and hemodynamic disorders. When DN occurs, cells in the kidney produce oxidative stress under the stimulation of high glucose and other factors, secrete a large number of pro-inflammatory...
Claims
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IPC IPC(8): A61K45/06A61K31/225A61P3/10A61P13/12A61K31/198A61K31/165
CPCA61K45/06A61K31/165A61K31/198A61K31/225A61K2300/00
Inventor 傅继华
Owner CHINA PHARM UNIV