Tumor prognosis predicting marker and detection method thereof

A detection method and marker technology, applied in the direction of measuring devices, test sample preparation, sampling, etc., to achieve the effect of avoiding inconsistent detection

Inactive Publication Date: 2018-05-01
陈素贤
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  • Abstract
  • Description
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Problems solved by technology

[0005] At present, there are few reports at home and abroad on the correlation between regional lymph node reactive hyperplasia and the prognosis of malignant tumors

Method used

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Experimental program
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Embodiment Construction

[0032] The present invention is described in detail below.

[0033] The detection method of the tumor prognosis predictive markers of the present invention comprises the following steps:

[0034] 1) Making paraffin sections of lymph node tissue;

[0035] Diagnostic criteria for regional reactive lymph node hyperplasia After surgery, the lymph nodes in the resected specimens of 32 patients were divided into sub-stations and sent for pathological examination, which was completed by two pathologists with the title of deputy chief physician or above. The diagnostic criteria for lymph node reactive hyperplasia are: the largest diameter of the lymph node gross specimen is ≥ 8 mm, the histological structure can show a certain degree of lymphoid follicle hyperplasia, the number increases, the germinal center enlarges and proliferates, and the reticular cells and endothelial cells in the lymphatic sinus hyperplasia.

[0036] Histomorphological and immunohistochemical examinations wer...

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Abstract

The invention relates to a tumor prognosis predicting marker and a detection method thereof. The marker is a lymphoid node tissue; the detection method of the marker comprises the following steps of dewaxing, hydrating, heating at high pressure, interdicting endogenous peroxidase and the like. According to the tumor prognosis predicting marker and the detection method thereof provided by the invention, the marker is detected through the steps of dewaxing, hydrating, heating at high pressure, interdicting endogenous peroxidase and the like; multiple expression groups with different degrees areobtained according to different Ki67 proliferation indexes. The invention provides a new marker and a specific detection method thereof for tumor prognosis predicting, so that the occurrence of the phenomena of inconformity in detection and even opposite results on an immunohistochemical basis is avoided.

Description

technical field [0001] The invention relates to the technical field of prognosis prediction, in particular to a tumor prognosis prediction marker and a detection method thereof. Background technique [0002] Humans have realized in the process of conquering tumors that in order to truly defeat tumors, we should start from two aspects: one is how tumors occur, that is, the study of etiology, so as to take effective prevention; Tumors can be detected early, so that effective and targeted treatment can be adopted. In fact, whether it is basic research on etiology or clinical diagnosis and treatment research, it is all to prolong the survival time and improve the quality of life of patients, so that patients have a good prognosis. Therefore, it is very necessary to strengthen the exploration of the law of tumor prognosis. [0003] The tumor prognosis prediction markers in the prior art include: protein, messenger RNA, DNA, microRNA, metabolites, or the integration of such biom...

Claims

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Application Information

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IPC IPC(8): G01N21/84G01N1/28G01N1/30
CPCG01N1/286G01N1/30G01N21/84
Inventor 陈素贤何东宁王亚帝李琪
Owner 陈素贤
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