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Method for improving cognition

A technology for cognitive impairment and use, applied in the direction of anhydride/acid/halide active ingredients, ester active ingredients, nervous system diseases, etc., can solve the problem of no effective treatment for diseases, reduce incidence and improve cognition Effect

Inactive Publication Date: 2018-07-17
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Although behavioral therapy and other treatments can reduce the effects of Prader-Willi syndrome, there is no effective treatment for the disorder

Method used

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  • Method for improving cognition
  • Method for improving cognition
  • Method for improving cognition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0168] Materials and methods

[0169] animal

[0170] 21-month-old male Wistar rats were ordered from Janvier Labs (France) and acclimatized at the facility for 7 days. During this period, they were housed in pairs in cages.

[0171] After the acclimatization period, the rats were randomly divided into four groups according to cognition and body weight. Baseline cognition was tested by social cognition using the protocol described below.

[0172] Rats were housed individually in standard cages with free access to food and water and maintained under a 12-hour photoperiod at a temperature of 20°C-24°C and a relative humidity of 50%-60%. Rats were fed a diet of 5% medium chain triglycerides (MCTs): caprylic triglyceride (C8), capric triglyceride (C10), 40:60 of C8 and C10 triglycerides via specially formulated animal common chow Combination or control (5% sunflower oil) for 8 weeks.

[0173] social cognition

[0174] Rats were tested for behavioral effects of MCT by a...

Embodiment 2

[0194] Materials and methods

[0195] animal

[0196] 15-month-old male Wistar rats and 6-month-old male rats were ordered from Janvier Labs (France) and acclimatized at the facility for 7 days. During this period, they were housed in pairs in cages.

[0197] After the acclimatization period, the rats were randomly divided into four groups according to cognition and body weight. Baseline cognition was tested by social cognition using the protocol described in Example 1.

[0198] Rats were individually housed in standard cages with free access to food and water, and maintained under a 12-hour photoperiod at a temperature of 20°C-24°C and a relative humidity of 50%-60%. Rats were given a diet of 5% medium-chain triglycerides (MCTs): caprylic triglyceride (C8), capric triglyceride (C10), a 50:50 combination of C8 and C10 triglycerides or control (sunflower oil) , for 8 weeks.

[0199] result

[0200] Based on comparisons of object cognition at baseline and after chron...

Embodiment 3

[0203] UBE3A expression was analyzed in immature mice exposed to a caprylic acid homogeneous triglyceride (MCT8) diet during gestation and weaning (via nursing).

[0204] Materials and methods

[0205] animal

[0206]Female C57 mice were mated and pregnancy followed by vaginal smears. MCT8 was mixed in animal normal diet (1.5%) and administered to pregnant female mice between gestation day 10 and postpartum day 28, while pregnant mice received normal diet supplemented with 1.5% sunflower oil (control ).

[0207] On postnatal day 28, brains and livers of pups were collected, fixed, frozen, and processed for UBE3A expression.

[0208] To assess the effect of the treatment on cognitive performance, a subset of mice was tested on postnatal day 60 using the Morris water maze task. The equipment used for behavioral testing consisted of a gallon jug and a platform placed in one of the quadrants. Fill the jar with warm water (24°C) to make it opaque. Video cameras record ani...

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Abstract

A medium-chain triglyceride (MCT) or medium-chain fatty acid (MCFA) for use in improving cognition which has been impaired by UBE3A deficiency.

Description

technical field [0001] The present invention relates to the use of medium chain triglycerides (MCT) or medium chain fatty acids (MCFA) for improving cognition impaired due to UBE3A deficiency (for example, subjects with cognitive impairment or elderly subjects) . In particular, the present invention relates to the use of MCTs for the treatment of Angelman syndrome and / or Prader-Willi syndrome. Background technique [0002] UBE3A encodes a ubiquitin E3 ligase for targeting specific proteins for degradation (de Bie, P. and Ciechanover A. (2011) Cell Death Differ. 18:1393-402), and since it acts as the main role of ubiquitin-binding proteins and is therefore critical in normal cognitive function. The ability of UBE3A to clear synaptic signaling proteins (eg, Arc) allows homologous regulation of synapse growth. Loss of UBE3A expression disrupts long-term potentiation via the transcription factor Arc and also leads to dysregulation of glutamate receptor activity. Over time, l...

Claims

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Application Information

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IPC IPC(8): A61K31/19A61K31/20A61P25/28
CPCA23L33/12A61K31/20A61K31/23A61P25/28A61P43/00
Inventor E·S·米切尔A·M·普勒C·里克尔
Owner SOC DES PROD NESTLE SA
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