Tetronic acid derivative and preparation method and application thereof

A technology of quaternary keto acids and derivatives, which is applied in the field of killing acaricides and agricultural insecticides, and can solve problems such as undisclosed compounds and undisclosed compound activities.

Pending Publication Date: 2018-10-02
ZHEJIANG RES INST OF CHEM IND CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The prior art does not disclose the compound described in the present application, nor does it disclose the activity of the compound described in the present application in killing insects or acaricides

Method used

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  • Tetronic acid derivative and preparation method and application thereof
  • Tetronic acid derivative and preparation method and application thereof
  • Tetronic acid derivative and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0245] Embodiment 1, preparation target compound 2231

[0246]

[0247] Add 0.312g of intermediate A to a 50ml flask, add 20ml of acetonitrile and 0.200g of potassium carbonate, then add a catalytic amount of sodium iodide and 0.210g of intermediate B, the system is stirred and heated to reflux for a reaction, and plate chromatography tracks the reaction for about 6hr After completion, the system was filtered, the mother liquor was evaporated to dryness with a rotary evaporator, and the residue was purified with plate chromatography to obtain 0.220 g of the product.

Embodiment 2

[0248] Embodiment 2, preparation target compound 286

[0249]

[0250] Add 0.312g of intermediate A to a 50ml flask, add 20ml of acetonitrile and 0.200g of potassium carbonate, then add a catalytic amount of sodium iodide and 0.190g of intermediate C, the system is stirred and heated to reflux for a reaction, and plate chromatography tracks the reaction for about 5hr After completion, the system was filtered, the mother liquor was evaporated to dryness with a rotary evaporator, and the residue was purified with plate chromatography to obtain 0.230 g of the product.

Embodiment 3

[0251] Embodiment 3, preparation target compound 2176

[0252]

[0253] Add 0.312g of intermediate A to a 50ml flask, add 20ml of acetonitrile and 0.200g of potassium carbonate, then add a catalytic amount of sodium iodide and 0.190g of intermediate F, the system is stirred and heated to reflux for a reaction, and plate chromatography tracks the reaction for about 6hr After completion, the system was filtered, the mother liquor was evaporated to dryness with a rotary evaporator, and the residue was purified with plate chromatography to obtain 0.172 g of the product.

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PUM

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Abstract

The invention discloses a tetronic acid derivative with the general formula of stru-1 or stru-2. The general formula and substituent group definitions are shown in the specification. The invention further provides a preparation method of the tetronic acid derivative and farm-oriented insecticide and acaricide containing the tetronic acid derivative. The tetronic acid derivative is suitable for preventing and controlling pests.

Description

technical field [0001] The invention belongs to the field of agricultural insecticide and acaricide, and in particular relates to a tetronic acid derivative. Background technique [0002] The long-term use of existing pesticides has led to the resistance of diseases and insect pests to them, which has led to a significant increase in the use of pesticides and caused serious damage to the environment. Therefore, it is required to continuously discover new pesticides with new mechanisms of action, for example, new pesticides with higher activity on insecticide, bactericide or acaricide. [0003] PCT patent applications WO99 / 16748, WO99 / 24437, WO99 / 43649, WO99 / 48869, WO99 / 55673, WO01 / 17972, WO01 / 23354, WO01 / 74770, WO03 / 013249, WO04 / 007448, WO04 / 024688, WO04 / 065366, WO04 / 080962, WO04 / 111042, WO05 / 044791, WO05 / 044796, WO05 / 048710, WO05 / 049569, WO05 / 066125, WO05 / 092897, WO06 / 000355, WO06 / 0295699, WO08 / 208 / 2 WO06 / 089633, WO95 / 26345, WO96 / 20196, WO96 / 25395, WO96 / 35664, WO97 / 01535...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/94C07D209/54C07D471/10C07D491/113A01N43/90A01N43/38A01N43/12A01P7/02A01P7/04A01P5/00
CPCA01N43/12A01N43/38A01N43/90C07D209/54C07D307/94C07D471/10C07D491/113
Inventor 许天明袁静钟良坤孔小林董德臻黄红英郁季平魏优昌
Owner ZHEJIANG RES INST OF CHEM IND CO LTD
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