Method for preparing drug-carrying nanoparticles of core-shell structure

A drug-loaded nano, core-shell structure technology, applied in the preparation of microspheres, microcapsule preparations, etc., can solve the problems of applicability limitations, achieve the effects of increasing emission sources, increasing production, and reducing initial drug release

Active Publication Date: 2018-11-20
温州品卓生物科技有限公司
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Problems solved by technology

Therefore, the applicability of this device is greatly limited in applications

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  • Method for preparing drug-carrying nanoparticles of core-shell structure
  • Method for preparing drug-carrying nanoparticles of core-shell structure
  • Method for preparing drug-carrying nanoparticles of core-shell structure

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Embodiment Construction

[0020] The method for preparing core-shell structured drug-loaded nanoparticles includes the following steps:

[0021] (1) Take a transparent glass slide and a microfluidic chip each. The microfluidic chip is provided with an external phase solution interface, an internal phase solution interface, and a side channel communicating with the center of the microfluidic chip; fully clean with cleaning tape After the glass slide and microfluidic chip are corona activated for 3 minutes, the glass slide and microfluidic chip are bonded together, and they are dried in air at 60℃ (electrically heated blast drying oven) ) The microfluidic chip must be fixed on the glass slide after 2h;

[0022] (2) Drop acetone on the outlet of the side channel of the microfluidic chip, insert one end of the capillary into the channel of the microfluidic chip to the center of the microfluidic chip, and then use a mixture of 0.01mL PDMS liquid and curing agent to connect the capillary with the microfluidic Th...

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Abstract

The invention discloses a method for preparing drug-carrying nanoparticles of a core-shell structure. The method comprises two parts, namely manufacture of a capillary micro-fluidic chip and preparation of nanoparticles. The invention firstly provides a micro-fluidic chip prepared from polydimethylsiloxane (PDMS) as the material for replacing the traditional coaxial syringe needle, taxol-carryingnanoparticles of the core/shell structure having the uniform particle size and narrow particle size distribution are prepared by combining with the coaxial electrostatic spraying method, the feasibility of the micro-fluidic chip for preparing drug-carrying nanoparticles is proved, and the problems that the nanoparticles prepared by the traditional method have the sudden release phenomenon and thePDMS array transmitter is not resistant to tetrahydrofuran, chloroform, acetone or other organic solvents are solved. Moreover, preparation of multilayer and composite structure nanoparticles can berealized.

Description

Technical field [0001] The invention belongs to the technical field of nanoparticle preparation, and specifically relates to a method for preparing a core-shell structure drug-loaded nanoparticle. Background technique [0002] Coaxial electrohydrodynamic atomization (CEHDA) is a new type of technology that can prepare polymer nanoparticles and microbubbles containing therapeutic drugs. Depending on the nature of the liquid, the flow rate of the liquid and the applied potential change, and different CEHDA patterns (ie, dripping, cone spraying, or multiple spraying) may occur. Cone jet mode is the best CEHDA condition for producing uniform particles. The drug-loaded particles can achieve precise drug release with the smallest batch-to-batch variation. The method can directly introduce the drug into the core layer of the nanoparticle, and the shell polymer protects the drug in the core layer to a certain extent, and can effectively overcome the initial burst of drug release. In a...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/04
CPCB01J13/043
Inventor 陈传品刘文芳邓喆蒋屏曾文昕郭鹏辉
Owner 温州品卓生物科技有限公司
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