Process method for bone marrow smear digitization

Abstract

The invention discloses a process method for bone marrow smear digitization. The process method comprises the following steps: acquiring related information of bone marrow smears, generating global images, and performing digital labeling after obtaining the to-be-digitized area as well as karyocyte collecting quantity and megakaryocyte classifying quantity; feeding the bone marrow smears into scanning equipment for performing shooting scanning: a to-be-digitized area generated by low-power lens scanning, and labeling and recognizing object observers therein; generating a spliced image in the scanning area; switching to megakaryocyte in the megakaryocyte classifying quantity generated by high-power lens scanning, and labeling and recognizing the megakaryocyte; generating the scanned megakaryocyte image; switching to karyocyte in the karyocyte collecting quantity in the to-be-digitized area generated by oil lens scanning, labeling and recognizing the karyocyte; generating the scanned karyocyte image; and generating digitalized smears of physical bone marrow smears. The artificial microscopy process is simplified; the consistency and standardization of the bone marrow examination report results are improved; and remote consultation is conveniently carried out, and the turn-round time of the physical smears is reduced.

Description

technical field [0001] The invention belongs to the field of computerized medical bone marrow smear examination, and in particular relates to a process method for digitizing bone marrow smears. Background technique [0002] Microscopic examination of bone marrow cell morphology is one of the key diagnostic methods in hematology and is commonly used to diagnose a variety of diseases, including leukemia, multiple myeloma, lymphoma, anemia and pancytopenia. According to the "Guidelines for the Diagnosis of Myeloid Malignant Tumors" issued by the World Health Organization, detailed and precise microscopic manual examination is required for diagnosis. Normal bone marrow contains differentiated cells at all stages of development, from early precursor stem cells to functionally mature cells, including hematopoietic stem cells, which are precursors to most blood cells, and mesenchymal and endothelial stem cells, which are considered the gatekeeper cells of the bone marrow. The morp...

AI Technical Summary

Problems solved by technology

Long-time artificial microscope observation can also easily cause fatigue to the eyes and cervical spine of morphological inspectors

[0004] (2) Strong work experience is required

Therefore, the training of qualified hematologists / pathologists is also a long and boring process. Coupled with the influence of some other factors, it has also led to the phenomenon of lack of morphological inspection personnel and faults in many hospitals.

[0005] (3) Microscopic examination standards are not uniform

Under the influence of the specific environment of the automation of blood cell analyzers, some originally weak blood cell inspection departments have relaxed the inspection and diagnosis of blood cell morphology, which has affected the development of blood morphology and the improvement of the overall diagnostic level