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Quality detection of sugar-free cold cough-relieving granules

A quality inspection method, a cold and cough technology, which is applied to measuring devices, instruments, scientific instruments, etc., can solve the problems that the production process and product quality of cold and cough granules cannot be effectively controlled, and the efficacy of drugs cannot be better guaranteed.

Active Publication Date: 2018-12-18
HARBIN KANGLONG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In the prior art, there is no relatively comprehensive quality control method to reflect the quality status of Ganmaozhike Granules, so it is impossible to effectively control the production process and product quality of Ganmaozhike Granules, and it is impossible to better guarantee its drug efficacy

Method used

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  • Quality detection of sugar-free cold cough-relieving granules
  • Quality detection of sugar-free cold cough-relieving granules
  • Quality detection of sugar-free cold cough-relieving granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] 1.1 Identification of menthol:

[0076] Preparation of the test solution: Take 15g of this product, grind it finely, put it in a round-bottomed flask, add 40mL of water, seal it, ultrasonic for 3min, and soak for 25min; continue to add 160mL of water, connect the volatile oil measuring device, and add 40ml of water from the upper end of the measuring device to make Water overflows to the flask, add ethyl acetate 5ml, connect the reflux condenser, heat slowly to boiling and keep boiling slightly for 1.0 hour, stop heating, separate the ethyl acetate layer, and quickly use anhydrous sodium sulfate Filter through the funnel, wash the volatile oil extractor and filter with a small amount of ethyl acetate, put the filtrate in a 10ml measuring bottle, dilute to the mark with ethyl acetate, shake well, and use it as the test solution;

[0077] Preparation of reference substance solution: take menthol reference substance, add ethyl acetate to make a solution containing 2 mg per...

Embodiment 2

[0100] 2.1 Identification of Artemisia annua:

[0101] Preparation of the test solution: Take 3g of this product, grind it finely, add 40ml of water, heat and reflux for 1h, filter, shake the filtrate with petroleum ether to extract 2 times, 30ml each time, take 10ml of the aqueous layer solution, and shake with ethyl acetate Extract 2 times, 10ml each time, combine the ethyl acetate solution, recover the solvent to dryness, add 2ml of ethanol to the residue to dissolve, and use it as the test solution;

[0102] Preparation of the reference substance solution: take 1 g of the reference medicinal material of Artemisia annua, add 15 ml of water, heat and reflux for 1 hour, filter, and the filtrate is prepared into the reference medicinal material solution in the same way;

[0103] Negative reference substance solution preparation: according to the prescription, take the remaining medicinal materials except Artemisia annua to make a negative control sample without Artemisia annua...

Embodiment 3

[0120] 3.1 Identification of Bupleurum:

[0121] Preparation of the test solution: Take 6g of this product, add 30ml of water, heat and reflux for 1h, filter, shake and extract the filtrate twice with petroleum ether, 15ml each time, take 10ml of the aqueous layer solution, shake and extract with n-butanol saturated with water for 2 Once, 20ml each time, combine the n-butanol solution, wash with 40ml of 1% sodium hydroxide solution, discard the washing solution, then wash with 40ml of water saturated with n-butanol, discard the washing solution, and recover the solvent from the n-butanol solution to Dry, add methanol 1ml to the residue to dissolve, and use it as the test solution;

[0122] Preparation of the reference substance solution: take 1 g of Bupleurum reference medicinal material, add 15 ml of water to prepare the reference medicinal material solution in the same way;

[0123] Negative reference solution preparation: according to the prescription, take the rest of the...

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Abstract

The invention relates to a quality control method of a traditional Chinese medicine preparation, and specifically discloses a quality detection method of sugar-free cold cough-relieving granules. Themethod comprises the steps of distinguishing menthol, Artemisia apiacea, radix bupleuri, fructus forsythia, the root of kudzu vine and lonicerae flos in the sugar-free cold cough-relieving granules byadopting a thin-layer chromatography, and measuring the content of each of the baicalin, puerarin and chlorogenic acid in the sugar-free cold cough-relieving granules by adopting the high-performanceliquid chromatography. By adopting the thin-layer chromatography, the quality detection method disclosed by the invention is good in reproducibility, strong in specificity and good in durability; thequality control of the medicine is improved, the qualitative and quantitative detection of the medicine is more accurate, and the quality can be easier controlled.

Description

technical field [0001] The invention relates to a quality control method of traditional Chinese medicine preparations, in particular to a quality detection method of sugar-free Ganmaozhike granules. Background technique [0002] The main ingredients and content of sugar-free Ganmao Zhike Granules are as follows: [0003] [0004] Its preparation method is as follows: the above nine flavors, except menthol, and the other eight flavors such as Bupleurum, add water and decoct twice, each time for 4 hours, filter the decoction, combine the filtrates, concentrate to an appropriate amount, and spray-dry the concentrate to obtain Fine powder, add sucralose, dextrin and menthol (encapsulation with beta-cyclodextrin in appropriate amount), mix well, dry granulate, and make 300g (without sucrose). [0005] This sugar-free Ganmaozhike granule is mainly used for clearing away heat and relieving exterior syndrome, relieving cough and resolving phlegm. For colds caused by exogenous w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N30/02
CPCG01N30/02G01N30/90
Inventor 穆滨
Owner HARBIN KANGLONG PHARM CO LTD
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