Composite fiber of polylactide and polydioxanone, its preparation method, application and surgical suture

A polydioxanone and polylactide technology, which is applied to surgical sutures, its preparation, and the field of polylactide and polydioxanone composite fibers, can solve the problem of high price, limited wide application, degradation short time etc.

Active Publication Date: 2021-07-06
CHINESE TEXTILE ACAD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, most of the synthetic sutures in the domestic market are polyglycolic acid (PGA) and lactide-glycolide copolymer (PGLA), and the polylactide used for biodegradable materials is due to its short degradation time and low strength. , clinically, in many surgical occasions where muscle tissue grows for a long time, therefore, its wide application is limited
However, polydioxanone (PDS) is expensive, which limits its wide application.

Method used

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  • Composite fiber of polylactide and polydioxanone, its preparation method, application and surgical suture
  • Composite fiber of polylactide and polydioxanone, its preparation method, application and surgical suture
  • Composite fiber of polylactide and polydioxanone, its preparation method, application and surgical suture

Examples

Experimental program
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Effect test

preparation example Construction

[0047] See attached figure 2 , the preparation method of polylactide provided by the invention and polydioxanone (PDS) composite fiber comprises the following steps:

[0048] Step 1: Obtain polylactide slices and polydioxanone (PDS) slices respectively;

[0049] Step 2: Composite spinning for polylactide chips and polydioxanone (PDS) sheets, so that polylactide is in the core layer of the composite fiber, and polydioxanone (PDS) wraps The polylactide is used to form the skin layer of the composite fiber, and the polylactide and polydioxanone (PDS) composite fiber is obtained.

[0050] Among them, the process of composite spinning for polylactide chips and polydioxanone (PDS) chips includes:

[0051] Vacuum drying is carried out under the condition of 80° C. to 100° C., and the vacuum degree of vacuum drying ranges from -0.08 MPa to 0.09 MPa.

[0052] Wherein, in step 1, the method for obtaining polydioxanone (PDS) slices comprises the following steps:

[0053] After vacuu...

Embodiment 1

[0070] The cross-sectional area ratio of the skin layer and the core layer (with PLA as the core of the composite fiber, and polydioxanone (PDS) as the skin of the composite fiber) is 20:80, and the spare PLA / polydioxane The hexanone (PDS) was vacuum-dried separately, the drying temperature was 80°C, and the vacuum degree was -0.09MPa. The composite fiber was spun-stretched in one step, and the draw ratio was 5 times. The monofilament fineness is 2.2dtex (50D / 24f). The spinning process conditions are: the temperature range of the core layer component is 200-220°C, the screw pressure is 9.8MPa, the spinning speed is 220m / min, the temperature range of the skin layer component is 140-170°C, the screw pressure is 8.0MPa, the spinning The filament speed is 220m / min, air cooling, side blowing rate is 3m / min, PLA / polydioxanone (PDS) composite fiber can be obtained.

[0071] The performance parameters of PLA / polydioxanone (PDS) composite fiber are: the tensile strength reaches 4.0CN / ...

Embodiment 2～20

[0073]

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Abstract

Disclosed are polylactide and polydioxanone composite fiber, its preparation method, application and surgical suture. In the composite fiber, the polylactide fiber is the core layer of the composite fiber, and polydioxanone is the skin layer of the composite fiber. The preparation method comprises: obtaining polylactide slices and polydioxanone slices respectively; performing composite spinning on the polylactide slices and polydioxanone slices, so that the polylactide is in the composite fiber The core layer, and the polydioxanone wraps the polylactide to form the skin layer of the composite fiber, and obtains the composite fiber of polylactide and polyglycolide. The composite fiber can be used for surgical sutures. The surgical suture is prepared via the composite fiber. The value range of the tensile strength of the composite fiber is 4.0CN / dtex-5.2CN / dtex, and the value range of the elongation at break is 20%-30%, which can meet the requirements of surgical sutures and is low in cost.

Description

technical field [0001] The invention relates to the technical field of composite fibers, in particular to a composite fiber of polylactide and polydioxanone, its preparation method, application and surgical suture. Background technique [0002] Polylactide, also known as polylactic acid, has a hydroxyl group and a carboxyl group in a single lactic acid molecule, multiple lactic acid molecules are together, -OH is dehydrated and condensed with -COOH of other molecules, and -COOH is dehydrated with -OH of other molecules Condensation, and just like that, they go hand in hand to form a polymer called polylactic acid, or polylactide. Polylactide is a polymer obtained by polymerization of lactic acid as the main raw material. The raw material source is sufficient and can be regenerated. The production process of polylactide is non-polluting, and the product can be biodegraded to realize the cycle in nature, so it is an ideal green polymer material. Polydioxanone (PDS) materials...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F8/14D01D5/34A61L17/06A61L17/10A61L17/12
CPCA61L17/06A61L17/10A61L17/12D01D5/34D01F8/14C08L67/04
Inventor 刘伯林黄庆金剑
Owner CHINESE TEXTILE ACAD
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