A kind of surfactant composition applied to in vitro diagnostic reagent

A surfactant, in vitro diagnostic technology, used in biological testing, material inspection products, etc.

Active Publication Date: 2021-09-10
WHITMAN BIOTECH NANJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current conventional surfactants have certain limitations in the interaction with BSA. Therefore, a kind of efficient surfactants needs to be developed urgently.

Method used

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  • A kind of surfactant composition applied to in vitro diagnostic reagent
  • A kind of surfactant composition applied to in vitro diagnostic reagent
  • A kind of surfactant composition applied to in vitro diagnostic reagent

Examples

Experimental program
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Effect test

Embodiment 1

[0021] A surfactant composition applied to an in vitro diagnostic reagent, comprising: 20 mM sucrose-glucose-sodium 6-carboxylate-fructose-sodium 6-carboxylate-1-(N-dodecylformamide), 35mM sodium perfluorooctanoate, 30mM tetradecyltrimethylammonium bromide, 0.15mM Gemini Surfactant 12-2-12, 0.5% (w / v) Tween 20 and 1% (w / v) of Triton-100.

Embodiment 2

[0023] A surfactant composition applied to an in vitro diagnostic reagent, comprising: 25mM sucrose-glucose-sodium 6-carboxylate-fructose-sodium 6-carboxylate-1-(N-dodecylformamide), 38mM sodium perfluorooctanoate, 40mM tetradecyltrimethylammonium bromide, 0.15mM Gemini Surfactant 12-2-12, 0.5% (w / v) Tween 20 and 1% (w / v) of Triton-100.

Embodiment 3

[0025] A surfactant composition applied to an in vitro diagnostic reagent, comprising: 30 mM sucrose-glucose-sodium 6-carboxylate-fructose-sodium 6-carboxylate-1-(N-dodecylformamide), 45mM sodium perfluorooctanoate, 45mM tetradecyltrimethylammonium bromide, 0.15mM Gemini Surfactant 12-2-12, 0.5% (w / v) Tween 20 and 1% (w / v) of Triton-100.

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Abstract

The invention provides a surfactant composition applied to in vitro diagnostic reagents, which belongs to the technical field of surfactants, and the components include: sucrose-glucose-6-sodium carboxylate-fructose-6-sodium carboxylate-1-(N- lauryl formamide), sodium perfluorooctanoate, tetradecyltrimethylammonium bromide and Gemini surfactant 12‑2‑12, of which sucrose‑glucose‑6‑sodium carboxylate‑fructose‑6‑sodium carboxylate The content of ‑1‑(N‑dodecylformamide) is 5‑80mM, the content of sodium perfluorooctanoate is 10‑100mM, the content of tetradecyltrimethylammonium bromide is 10‑100mM, Gemini surfactant The content of 12‑2‑12 is 0.1‑2mM. The invention can optimize the reaction system of the in vitro diagnostic kit, improve performance indicators such as the repeatability, batch-to-batch difference, accuracy and stability of the kit, and help prolong the validity period of the in vitro diagnostic reagent.

Description

technical field [0001] The invention belongs to the technical field of surfactants, and in particular relates to a surfactant composition applied to in vitro diagnostic reagents. Background technique [0002] Surfactant refers to a substance with fixed hydrophilic and lipophilic groups that can be aligned on the surface of the solution and significantly reduce the surface tension of the solvent at a very low concentration. Its molecule is composed of two parts, a non-polar hydrophobic group and a polar hydrophilic group. By reducing the surface tension of the aqueous solution and the interfacial tension between oil / water, the surfactant forms aggregates in the solution, and then has the functions of solubilizing organic matter in the aqueous phase or solubilizing water in the organic phase, as well as emulsifying, dispersing, and solubilizing. , washing, soaking, foaming, defoaming and other capabilities. Bovine serum albumin (BSA) is a globulin in bovine serum. BSA can ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68
CPCG01N33/68
Inventor 郑佳孙文勇梁芬费云燕常俊骏
Owner WHITMAN BIOTECH NANJING
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