Use of a compound and its hydrate, salt or derivative

A technology of compounds and compound structural formulas, applied in microorganisms, biochemical equipment and methods, drug combinations, etc., can solve the problem of high morbidity, disability and mortality, no significant breakthroughs, disease complexity and nerve repair difficulties. and other problems, to achieve effective therapeutic effect and good brain targeting effect

Active Publication Date: 2022-03-25
SOUTHWEST JIAOTONG UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Ischemic stroke is still one of the major diseases that endanger human life. Its morbidity, disability and mortality are extremely high. Due to the complexity of the disease and the difficulty of nerve repair, there is still a lack of effective treatment. with prognostic means
Various treatment options such as anti-inflammation and anti-oxidation have been reported, but no significant breakthrough has been made in the evaluation of clinical treatment effects.

Method used

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  • Use of a compound and its hydrate, salt or derivative
  • Use of a compound and its hydrate, salt or derivative
  • Use of a compound and its hydrate, salt or derivative

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Embodiment Construction

[0028] The present invention will be further described in detail through specific implementation examples below.

[0029] 1 Materials and methods

[0030] 1.1 Materials

[0031] 1.1.1 Reagents and instruments

[0032] Fetal bovine serum (Gibco batch number: 1908121); DMEM low-glucose medium (Hyclone, batch number: J180003); trypsin (Hyclone, batch number: J180003); tetramethyl azolium salt (MTT) (Ruisai Biological Company, batch number: 180315); 2,3,5-triphenyltetrazolium chloride (TTC) (Yuanye Biotechnology Co., Ltd., batch number: BCBR5460V); 4% paraformaldehyde (Biosharp, batch number: 180119); 96-well plate ( Thermo, batch number: 167008); hematoxylin staining solution set (Wuhan Google Biotechnology Co., Ltd., batch number: G1005); NESTIN primary antibody (Wuhan Google Biotechnology Co., Ltd., batch number: GB12137); GFAP primary antibody (Wuhan Google Biotechnology Co., Ltd. , batch number: GB11096); NSE primary antibody (Wuhan Google Biotechnology Co., Ltd., batch nu...

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Abstract

The invention relates to the field of pharmacy, especially the use of a compound or its pharmaceutically acceptable hydrate, salt or derivative as an inducer in inducing stem cells to differentiate into nerve-like cells. After the inducer of the present invention induces bMSCs to differentiate into nerve-like cells in vitro, it will have better brain targeting, and can be more distributed in brain lesion sites to exert a more effective therapeutic effect.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the use of a compound and its hydrate or salt. Background technique [0002] Ischemic stroke is still one of the major diseases that endanger human life. Its morbidity, disability and mortality are extremely high. Due to the complexity of the disease and the difficulty of nerve repair, there is still a lack of effective treatment. with prognostic means. Various treatment options such as anti-inflammation and anti-oxidation have been reported, but no significant breakthrough has been made in the evaluation of clinical treatment effects. It is gratifying that the use of stem cells in the treatment of cardiovascular and cerebrovascular diseases has become a new research hotspot, and it also provides a new direction for the treatment of cerebral ischemia. Among them, bone marrow mesenchymal stem cells (Bone Marrow Mesenchymal Stem Cells, bMSCs) is a kind of non-hematopoietic tissue stem cel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/93A61P9/10A61P25/00C12N5/079
CPCA61P9/10A61P25/00C12N5/0618C07D307/93C12N2501/999C12N2506/1353
Inventor 谭锐谭立伟江羽
Owner SOUTHWEST JIAOTONG UNIV
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