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Culture system for mesenchymal stem cells

A technology of stem cell culture and bone marrow mesenchyme, which is applied in the fields of cell biology and tissue engineering, can solve the problems of temperature adjustment lag, cumbersome process, and large number of iterations, so as to increase the operating speed, improve computing efficiency, and reduce iterations The effect of times

Inactive Publication Date: 2019-04-16
GUANGDONG CARDIOVASCULAR INSITITUTE +1
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0004] (1) At present, the cultivation process of bone marrow stem cells is complicated, mainly by manual operation, with heavy workload, cumbersome process and low efficiency. Meet the requirements of bone marrow mesenchymal stem cell culture system
[0005] (2) The traditional temperature regulation system lags behind the regulation of temperature, it is difficult to determine the influence of temperature on cell culture, and cannot be applied to the cell culture system
[0006] (3) The measurement of pH value will also be affected by temperature. Traditional acid-base adjustments ignore the influence of temperature on pH, but the control of acid-base in cell culture systems is stricter, and the influence of temperature on pH will have a significant impact Cell culture has some effect

Method used

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  • Culture system for mesenchymal stem cells
  • Culture system for mesenchymal stem cells
  • Culture system for mesenchymal stem cells

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Embodiment Construction

[0038] In order to further understand the content, characteristics and effects of the present invention, the following examples are cited hereby, and in conjunction with the attached figure 1 The details are as follows.

[0039] The structure of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0040] Such as figure 1 As shown, the bone marrow mesenchymal stem cell culture system includes: temperature adjustment module 1, acid-base adjustment module 2, pressure adjustment module 3, control module 4, culture medium 5, biological enzyme 6, cleaning module 7, detection module 8, A cultivation module 9 , a freezer storage box 10 , and a mother liquor injection module 11 .

[0041] The control module 4 controls the temperature adjustment module 1, the acid-base adjustment module 2, the pressure adjustment module 3, and controls the culture medium 5, the biological enzyme 6, and the cleaning module 7;

[0042] The mother liqu...

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Abstract

The invention belongs to the field of cytobiology and tissue engineering and discloses a culture system for mesenchymal stem cells. A control module is arranged, controls a temperature adjustment module, an alkalinity-acidity adjustment module and a pressure intensity adjustment module and controls a culture solution, a biological enzyme and a cleaning module; a mother solution injection module injects a mother solution into a culture module, the temperature adjustment module, the alkalinity-acidity adjustment module and the pressure intensity adjustment module adjust the outer environment ofthe culture module, and the working process on the culture module is achieved through the culture solution, the biological enzyme and the cleaning module. According to the culture system, the mesenchymal stem cells are intelligently cultured, and a large number of mesenchymal stem cells can be automatically produced just by injecting the mother solution into the system.

Description

technical field [0001] The invention belongs to the fields of cell biology and tissue engineering, and in particular relates to a bone marrow mesenchymal stem cell culture system. Background technique [0002] Bone marrow mesenchymal stem cells (BMSCs for short) are another important adult stem cells in the bone marrow besides hematopoietic stem cells, which participate in the formation of the hematopoietic microenvironment. Bone marrow mesenchymal stem cells have the potential of self-renewal and multidirectional differentiation, and can be induced to differentiate into adipocytes, muscle cells, osteoblasts, chondrocytes, nerve cells and liver cells; in addition, bone marrow mesenchymal stem cells can secrete cytokines And growth factors, can play an immunomodulatory role through paracrine and endocrine mechanisms to repair damaged tissues and organs. At the same time, bone marrow mesenchymal stem cells also have the characteristics of low immunogenicity, convenient materi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00C12M1/38C12M1/36C12M1/00
CPCC12M21/18C12M23/02C12M39/00C12M41/12C12M41/26
Inventor 朱平刘南波庄建陈寄梅郭惠明陈瑞平朱烁基钟颖覃庚亮胡海燕杨雷温瑜林刘京奇杨贵林黄萍陈尘庄东林姜浩东莫环琦李星胡永争叶兴
Owner GUANGDONG CARDIOVASCULAR INSITITUTE
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