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Method for improving the adhesion performance of polyacrylamide hydrogel and the obtained polyacrylamide hydrogel

A polyacrylamide and acrylamide technology, which is applied in the field of biomedical materials, can solve problems such as lack of adhesion properties, and achieve the effects of improving adhesion properties, improving adhesion, and improving self-healing properties.

Active Publication Date: 2021-11-12
JIANGHAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Most of the self-healing hydrogels currently reported require certain external stimuli to complete, and they still lack certain adhesion properties, so other means are needed to achieve the adhesion effect.

Method used

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  • Method for improving the adhesion performance of polyacrylamide hydrogel and the obtained polyacrylamide hydrogel
  • Method for improving the adhesion performance of polyacrylamide hydrogel and the obtained polyacrylamide hydrogel
  • Method for improving the adhesion performance of polyacrylamide hydrogel and the obtained polyacrylamide hydrogel

Examples

Experimental program
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Embodiment 1

[0062] Prepare 0.01mol / L PBS buffer solution (1L)

[0063] Add 800mL of deionized water, 7.9g of sodium chloride, 0.2g of potassium chloride, 0.24g of potassium dihydrogen phosphate and 1.8g of dipotassium hydrogen phosphate into a 1L volumetric flask in sequence, and dissolve with magnetic stirring at room temperature. Adjust the pH of the solution to 7.2-7.4 with HCl, and finally add distilled water to make it up to 1L to obtain a 0.01mol / L PBS buffer solution. After the solution is prepared, store it in a refrigerator at 4°C.

[0064] Preparation of dopamine-modified sodium hyaluronate (HAC)

[0065] 1. At room temperature, weigh 1g of sodium hyaluronate, put it into a three-necked flask, then add 100mL of 1mol / L PBS buffer solution and a suitable magnet, stir until it is completely dissolved, adjust the pH of the solution to 5, and then Add catalyst 0.476g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) and 0.286g of N-hydroxysuccinimide (NHS), fully stir and disso...

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Abstract

The invention provides a method for improving the adhesion performance of polyacrylamide hydrogel and the obtained polyacrylamide hydrogel. The method comprises the following steps: (1) uniformly mixing a modified product of hyaluronic acid or its salt grafted with dopamine and soluble tetraborate in deionized water to form a first cross-linked network; (2) adding acrylamide , cross-linking agent, and then add initiator and tetramethylethylenediamine under ice-bath conditions, mix uniformly and then polymerize at 0-4°C to obtain polyacrylamide hydrogel, wherein, in step (1), the The dopamine graft rate of modified product is 30%~32%, and the mass ratio of described modified product and tetraborate is 5:(2~1); The acrylamide that adds in the step (2) and step (1 ), the mass ratio of the modified substance in ) is (18-20):1, and the hyaluronate is potassium salt or sodium salt. The method can greatly improve the adhesive performance of the prepared polyacrylamide hydrogel.

Description

technical field [0001] The invention relates to biomedical materials, in particular to a method for improving the adhesion performance of polyacrylamide hydrogel and the obtained polyacrylamide hydrogel. Background technique [0002] Self-healing hydrogels are a class of hydrogel materials that can quickly self-heal the fracture interface and restore the original properties after the structure is damaged. Due to its good self-healing properties, it can not only prolong the service life of the material, but also improve the safety performance of the material, so it is widely used in the fields of biosensing, bionic electronic skin and wearable electronic devices. [0003] Most of the self-healing hydrogels reported so far require certain external stimuli to complete, and they still lack certain adhesion properties, so other means are needed to achieve the adhesion effect. Studies have shown that the podocytes of marine mussels can secrete a kind of silk with adhesive propert...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L5/08C08L33/26C08F220/56C08F222/38C08B37/08
CPCC08B37/0072C08F220/56C08J3/075C08J2305/08C08J2433/26C08F222/385
Inventor 曹一平贝中武黄园尤庆亮
Owner JIANGHAN UNIVERSITY
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