The invention discloses a foldable all-terrain bicycle including a frame, wheels mounted on the frame, a seat, a handle, pedals, a wheel drive transmission system, and a wheel differential system, theframe includes a frame rail, a frame rail and a wheel support frame, and the frame rail, the frame rail, the frame rail and the wheel support are connected by a frame hinge. The handle and a seat aremount on that cross bar of the frame, a wheel comprises a hub, a tire plate unit and a tire drive shaft, the wheel drive transmission system comprises a center drive mechanism, a front wheel drive mechanism and a rear wheel drive mechanism, a wheel differential system comprises a differential and a differential locking mechanism, and a differential comprises a differential housing, a differentialdrive shaft, a differential drive shaft and a drive gear set. The invention is convenient to disassemble, assemble and fold, convenient to travel and carry, stable to ride, good in shock absorbing effect, capable of passing through various bad road conditions and switching between different road conditions, good in safety and reliability, and wide in application range.