The invention discloses an airflow-guide-type directional in-situ electrostatic spraying device which comprises a spray gun, an injector and a high-voltage electrostatic generator. The spray gun comprises a spray gun handle and a spray gun pipe, a hollow metal capillary pipe coaxial with a spray gun sprayer is arranged in the spray gun pipe and communicated with the injector through a liquid incoming pipe, an annular passage formed between the spray gun pipe and the metal capillary pipe is an airflow passage, communicated with the spray gun handle and communicated with an airflow guide pipe through the spray gun handle, and a pipe cavity of the metal capillary pipe is connected with the high-voltage electrostatic generator through a guide line. Airflow of the airflow passage plays a role in orientation and constraining, ring wrapping effect and faraday cage effect are weakened, a spraying area is limited within a very small range, orientation and fixed-point spraying, of a drug solution, in a specific area are realized, and the drug solution is almost free of splashing, thereby being high in utilization rate and having better treatment effect.