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A kind of antibacterial dressing for skin cancer chemotherapy and preparation method thereof

A technology of skin cancer and quaternization, applied in medical science, bandages, etc., can solve problems such as inability to continuously disperse, achieve the effects of improving recovery efficiency, easy-to-obtain materials, and good application prospects

Active Publication Date: 2021-09-03
四川维思达医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, most of the drugs clinically used for the treatment of skin cancer are fat-soluble and cannot be continuously dispersed in the hydrogel matrix.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Preparation of amino-modified Pluronic F127 drug-loaded micelles

[0030] a. Add 100 mg of aminated Pluronic F127 (NH 2 -F127, Mn=12600g / mol) and 10 mg of the drug are dissolved in 5 ml of acetonitrile solution, and then magnetically stirred at a speed of 100 to 200 r / min for 30 min, the drug is an anti-skin cancer fat-soluble drug;

[0031] b. Rotary evaporate the solution obtained in step a, the pressure is 0.06MPa, the rotary evaporation temperature is 25°C, the rotational speed is 300r / min, and the film is formed after 30min;

[0032] c. Heat the drug film obtained in b at 40°C until it is in a gel state, add 5ml of normal saline at the same temperature, stir evenly after fully hydrating, and freeze-dry to obtain powdery aminated F127 drug-loaded micelles;

[0033] (2) Preparation of quaternized polyglutamic acid

[0034] ①. Dissolve 1.47g of polyglutamic acid and 0.1g of acetylhydrazidetrimethylammonium chloride in 15ml of normal saline, stir for 15min at a s...

Embodiment 2

[0040] (1) Preparation of amino-modified Pluronic F127 drug-loaded micelles

[0041] a. Add 150 mg of aminated Pluronic F127 (NH 2 -F127, Mn=12600g / mol) and 15 mg of the drug are dissolved in 7.5 ml of acetonitrile solution, and then magnetically stirred at a speed of 100 to 200 r / min for 30 min, the drug is an anti-skin cancer fat-soluble drug;

[0042] b. Rotary evaporate the solution obtained in step a, the pressure is 0.065MPa, the rotary evaporation temperature is 28°C, the rotational speed is 300r / min, and the film is formed after 30min;

[0043] c. Heat the drug film obtained in b at 45°C until it is in a gel state, add 7.5ml of normal saline at the same temperature, stir evenly after fully hydrating, and freeze-dry to obtain powdery aminated Pluronic F127 drug-loaded micelles ;

[0044] (2) Preparation of quaternized polyglutamic acid

[0045] ①. Dissolve 1.47g of polyglutamic acid and 0.15g of acetylhydrazide trimethylammonium chloride in 15ml of normal saline, stir ...

Embodiment 3

[0051] (1) Preparation of amino-modified Pluronic F127 drug-loaded micelles

[0052] a. Add 200 mg of aminated Pluronic F127 (NH 2 -F127, Mn=12600g / mol) and 20mg of the drug are dissolved in 10ml of acetonitrile solution, then magnetically stirred at a speed of 100-200r / min for 30min, the drug is an anti-skin cancer fat-soluble drug;

[0053] b. Rotary evaporate the solution obtained in step a, the pressure is 0.07MPa, the rotary evaporation temperature is 32°C, the rotational speed is 300r / min, and the film is formed after 30min;

[0054] c. Heat the drug film obtained in b at 50°C until it is in a gel state, add 10ml of normal saline at the same temperature, stir evenly after fully hydrating, and freeze-dry to obtain powdery aminated Pluronic F127 drug-loaded micelles;

[0055] (2) Preparation of quaternized polyglutamic acid

[0056] ①. Dissolve 1.47g of polyglutamic acid and 0.2g of acetylhydrazidetrimethylammonium chloride in 15ml of normal saline, stir for 15min at a s...

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Abstract

The invention discloses an antibacterial skin cancer chemotherapy dressing and a preparation method thereof. The preparation method comprises the following steps: (1) dissolving amino-modified Pluronic F127 drug-loaded micelles in water, preparing a solution with a concentration of 2-6 wt%, and stirring uniform; (2) dissolve the quaternized polyglutamic acid in water, add tyramine hydrochloride, and prepare a polyglutamic acid solution with a concentration of 15 to 20 wt %; (3) mix the solution obtained in steps (1) and (2) Mix evenly, then add 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide, after stirring, pour the solution into the mold, after 2-5 minutes The dressing for antibacterial skin cancer chemotherapy is obtained after demoulding. The antibacterial skin cancer chemotherapy dressing prepared by the method of the present invention has an ideal uniform network structure, strong self-healing efficiency, broad-spectrum antibacterial properties, and prevents wound infection. Excision of infiltrating tumor tissue to prevent recurrence.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical materials, and in particular relates to an antibacterial skin cancer chemotherapy dressing and a preparation method thereof. Background technique [0002] In recent years, the number of skin cancer patients has been increasing. About 5 million people worldwide are diagnosed with skin cancer every year. In the United States, there is 1 skin cancer patient for every 5 people, and the prevalence rate is increasing year by year. Tumors located on the superficial skin are usually treated with surgical resection, but for invasive tumors, it is often difficult to remove them cleanly, and they tend to recur after surgery, resulting in treatment failure. Moreover, the gap-type surgical wound is prone to infection during the repair process, and the scar tissue is pulled too tightly after healing, which affects the patient's appearance. [0003] As a kind of gel material with water as the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00C08G69/48
Inventor 汪建新徐啟真陈太军王莹莹左莹莹翁杰冯波段可周宗国冯敬杨启远
Owner 四川维思达医疗器械有限公司
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