Application of combination of zoledronic acid and organic selenium compound in preparation of antitumor drugs

An anti-tumor drug, zoledronic acid technology, applied in the field of tumor treatment, can solve the problems of tumor cell apoptosis, DNA damage, cell cycle arrest, etc., and achieve the effect of efficiently inducing tumor cell apoptosis
CN109908159AActive Publication Date: 2019-06-21JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2019-06-21

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Abstract

The invention discloses application of the combination of zoledronic acid and an organic selenium compound in preparation of antitumor drugs. In-vitro cell experiments show that the inhibiting effectof the organic selenium compound alone or the zoledronic acid alone on tumor cells is not as good as that of the combination of the two, and the combination of the two can achieve a synergistic effect, that is, the synergistic effect of the organic selenium compound and the zoledronic acid can be utilized to efficiently induce apoptosis of the tumor cells. According to the application, the potential mechanism of action, in which the ability of the organic selenium compound to inhibit the growth of prostate cancer cells is enhanced by the zoledronic acid, is caused by the fact that the cells are induced to generate excessive ROS (reactive oxygen species). The zoledronic acid and the organic selenium compound can be combined to prepare the antitumor drugs, or the zoledronic acid is used as asensitizer for the organic selenium compound and is applied to the field of tumor therapy.
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Description

technical field

[0001] The invention relates to the technical field of tumor treatment, in particular to the combined use of zoledronic acid and an organic selenium compound in the preparation of antitumor drugs. Background technique

[0002] Prostate cancer is one of the common malignant tumors of the male genitourinary system, and the incidence rate is increasing year by year and tends to be younger. Because the onset of prostate cancer is hidden, its symptoms are often ignored. When it is diagnosed, about 65% to 75% have already There is bone metastases. Prostate cancer bone metastasis will cause a series of bone-related diseases, including pathological fractures, spinal cord compression, malignant tumor hypercalcemia, etc. Bone pain is the most common symptom of advanced prostate cancer, which seriously affects the quality of life of patients. Therefore, how to improve the treatment effect while relieving the patient's pain and ensuring the quality of life of the patien...

Claims

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