Application of hordenine in preparing drug for treating hypophysoma
A technology of hordenine and pituitary tumors, applied in the field of application of hordenine in the preparation of drugs for the treatment of pituitary tumors, can solve the problems of incompletely clear pathogenesis of Cushing's disease, high fatality rate, and poor prognosis of relapsed patients, and achieve The effect of addressing drug shortages
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[0063] 1. Establishment of tumor models
[0064] 1.1. Establishment of a prolactinoma model in rats.
[0065] Rat strains used in the rat pituitary prolactinoma model mainly include Fischer344 (F344) [34] rats, wistar-furth (Wister) rats, SD rats, etc. The inventors have found through experimental research that compared with Wister rats and SD rats, F344 rats are more sensitive, and the induced prolactinoma model has a shorter tumor formation time, and the tumor formation rate is as high as 100%. The operation is simple and easy, and No tumor metastasis or associated tumors will occur, and it is an ideal animal model for studying pituitary prolactinoma.
[0066] 80 F344 rats were randomly divided into normal group and model group, and rats in other groups except the normal group were made as prolactinoma models.
[0067] The model group needs to undergo ovariectomy first: the rats are anesthetized, placed on the fixed table in the abdominal position, the long hair is cut off...
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