Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of tetrandrine and extraction method of tetrandrine

A technology of tetrandrine and extraction method, which is applied in the field of chemistry, can solve the problems of low extraction rate, high polarity of tetrandrine, and great impact on operator health and environment, so as to improve extraction effect and improve spatial learning and memory ability, the effect of reducing the average escape latency

Active Publication Date: 2019-08-30
ACADEMY OF MILITARY MEDICAL SCI
View PDF6 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And tetrandrine is a methoxyl group, and tetrandrine is a phenolic hydroxyl group. The polarity of tetrandrine is small and can be dissolved in cold benzene, while tetrandrine is relatively polar and difficult to dissolve in cold benzene, so it is generally used Cold benzene separates powder tetrandrine and fangchinoline, but cold benzene is more toxic, has a greater impact on the health of operators and the environment, and has a low extraction rate, a large amount of waste liquid, and pollutes the environment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of tetrandrine and extraction method of tetrandrine
  • Application of tetrandrine and extraction method of tetrandrine
  • Application of tetrandrine and extraction method of tetrandrine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The present invention provides a method for extracting tetrandrine for treating microwave-radiated brain damage in rats, which includes:

[0035] S1. Take 100 parts by weight of tetrandrine to clean, dry and crush to obtain tetrandrine powder, then add 300 parts by weight of water and 30 parts by weight of sodium chloride solid to the tetrandrine powder, and then place it in 30kHz ultrasonic wave treatment 20min, get the first mixed solution, then place the first mixed solution in an electric field with a current of 4mA, and pass CO 2 Gas, CO 2 The gas flow rate is 20mL / min, and the gas flow time is 15min to obtain the second mixture;

[0036] S2. Place the second mixture in a centrifuge, centrifuge at 5000r / min for 20min, remove the precipitate, take the supernatant, and then dissolve the supernatant in 30 parts by weight of the first ether solution to obtain the first Three mixed liquids, and then the third mixed liquid is heated and refluxed in a water bath at 70° C. for ...

Embodiment 2

[0039] The present invention provides a method for extracting tetrandrine for treating microwave radiation brain injury in rats, which includes:

[0040] S1. Take 120 parts by weight of tetrandrine to clean, dry and grind to obtain tetrandrine powder, then add 500 parts by weight of water and 50 parts by weight of sodium chloride solid to the tetrandrine powder, and then place it in a 50kHz ultrasonic wave. 30min, get the first mixed solution, then place the first mixed solution in an electric field with a current of 8mA, and pass CO 2 Gas, CO 2 The gas flow rate is 20mL / min, and the gas flow time is 25min to obtain the second mixture;

[0041] S2. Place the second mixture in a centrifuge, centrifuge at 8000r / min for 30 minutes, remove the precipitate, take the supernatant, and then dissolve the supernatant in 50 parts by weight of the first ether solution to obtain the first Three mixed liquids, and then the third mixed liquid is heated and refluxed in a water bath at 80°C for 50 ...

Embodiment 3

[0044] The present invention provides a method for extracting tetrandrine for treating microwave-radiated brain damage in rats, which includes:

[0045] S1. Take 110 parts by weight of tetrandrine, clean, dry, and crush to obtain tetrandrine powder, then add 400 parts by weight of water and 40 parts by weight of sodium chloride solid to the tetrandrine powder, and then place it in 40kHz ultrasonic wave 25min, get the first mixed solution, then place the first mixed solution in an electric field with a current of 6mA, and pass CO 2 Gas, CO 2 The gas flow rate is 20mL / min, and the gas flow time is 20min to obtain the second mixed liquid;

[0046] S2. Place the second mixture in a centrifuge, centrifuge at 6500r / min for 25min, remove the precipitate, take the supernatant, and then dissolve the supernatant in 40 parts by weight of the first ether solution to obtain the first Three mixed liquids, and then the third mixed liquid is heated and refluxed in a water bath at 75° C. for extrac...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses an application of tetrandrine, and an extraction method of the tetrandrine, in particular to an application of the tetrandrine to treatment of microwave radiation brain damageof mice, and the extraction method of the tetrandrine. The tetrandrine can notably reduce the escape latency period of the mice, improve the spatial learning memory capacity of the mice and reinforcethe exploration spirit and the autonomic activity behavior of the mice.

Description

Technical field [0001] The invention relates to the field of chemistry. More specifically, the present invention relates to an application of tetrandrine and a method for extracting tetrandrine. Background technique [0002] Tetrandrine, also known as tetrandrine, also known as tartarin, tetrandrine A, is a colorless needle-like crystal, mainly used for analgesia, muscle relaxation, anti-allergic, anti-arrhythmic, anti-bacterial, anti-tumor and antihypertensive Anti-coagulation. Tetrandrine is mainly extracted from tetrandrine. Fenfangji is the dried root of the fangchi family plant Fenfangji, which has the effects of hydration, swelling, dispelling wind and pain relief. Modern pharmacological experiments have shown that the total alkaloids of fangchi has analgesic, hypotensive and muscle relaxation effects. The content of alkaloids in tetrandrine is relatively high, generally up to 1.5-2.0%, of which tetrandrine is mainly tetrandrine, followed by fangchinoline. [0003] At pre...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4748A61P39/00A61P25/00C07D491/18
CPCA61K31/4748A61P25/00A61P39/00C07D491/18
Inventor 左红艳杜丽娜金义光李杨张丽花朱思庆庞璐璐马金秋
Owner ACADEMY OF MILITARY MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com