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Application of tetrandrine and extraction method of tetrandrine

A technology of tetrandrine and an extraction method, applied in the field of chemistry, can solve the problems of high polarity of tetrandrine, great influence on operator's health and environment, low extraction rate, etc., so as to improve spatial learning and memory ability and reduce average Escape latency, improve extraction effect

Active Publication Date: 2021-02-26
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And tetrandrine is a methoxyl group, and tetrandrine is a phenolic hydroxyl group. The polarity of tetrandrine is small and can be dissolved in cold benzene, while tetrandrine is relatively polar and difficult to dissolve in cold benzene, so it is generally used Cold benzene separates powder tetrandrine and fangchinoline, but cold benzene is more toxic, has a greater impact on the health of operators and the environment, and has a low extraction rate, a large amount of waste liquid, and pollutes the environment

Method used

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  • Application of tetrandrine and extraction method of tetrandrine
  • Application of tetrandrine and extraction method of tetrandrine
  • Application of tetrandrine and extraction method of tetrandrine

Examples

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Effect test

Embodiment 1

[0034] The invention provides a method for extracting tetrandrine for treating microwave radiation brain damage in rats, comprising:

[0035] S1. Take 100 parts by weight of Fangji, wash, dry, and pulverize to obtain Fangji powder, then add 300 parts by weight of water and 30 parts by weight of sodium chloride solid to the Fangji powder, and then place it in a 30kHz ultrasonic wave for processing 20min, the first mixed solution was obtained, and then the first mixed solution was placed in an electric field with a current of 4mA, and CO 2 gas, CO 2 The gas flow rate was 20mL / min, and the gas injection time was 15min to obtain the second mixed solution;

[0036] S2. Place the second mixed solution in a centrifuge, centrifuge at a speed of 5000r / min for 20min, remove the sediment, take the supernatant, and then dissolve the supernatant in 30 parts by weight of the first ether solution to obtain the second mixture. Three mixed solutions, and then place the third mixed solution i...

Embodiment 2

[0039] The invention provides a method for extracting tetrandrine for treating microwave radiation brain damage in rats, comprising:

[0040] S1. Take 120 parts by weight of Fangji, wash, dry, and pulverize to obtain Fangji powder, then add 500 parts by weight of water and 50 parts by weight of sodium chloride solid to the Fangji powder, and then place it in a 50 kHz ultrasonic wave for processing 30min, the first mixed solution was obtained, then the first mixed solution was placed in an electric field with a current of 8mA, and CO 2 gas, CO 2The gas flow rate was 20mL / min, and the gas injection time was 25min to obtain the second mixed solution;

[0041] S2. Place the second mixed solution in a centrifuge, centrifuge at a speed of 8000r / min for 30min, remove the precipitate, take the supernatant, and then dissolve the supernatant in 50 parts by weight of the first ether solution to obtain the second mixture. Three mixed solutions, and then place the third mixed solution in...

Embodiment 3

[0044] The invention provides a method for extracting tetrandrine for treating microwave radiation brain damage in rats, comprising:

[0045] S1. Take 110 parts by weight of Fangji, wash, dry, and pulverize to obtain Fangji powder, then add 400 parts by weight of water and 40 parts by weight of sodium chloride solid to the Fangji powder, and then place it in a 40kHz ultrasonic wave for processing 25min, the first mixed solution was obtained, and then the first mixed solution was placed in an electric field with a current of 6mA, and CO 2 gas, CO 2 The gas flow rate was 20mL / min, and the gas injection time was 20min to obtain the second mixed solution;

[0046] S2. Place the second mixed solution in a centrifuge, centrifuge at a speed of 6500r / min for 25 minutes, remove the precipitate, take the supernatant, and then dissolve the supernatant in 40 parts by weight of the first ether solution to obtain the second mixture. Three mixed solutions, and then place the third mixed so...

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Abstract

The invention discloses an application of tetrandrine, and an extraction method of the tetrandrine, in particular to an application of the tetrandrine to treatment of microwave radiation brain damageof mice, and the extraction method of the tetrandrine. The tetrandrine can notably reduce the escape latency period of the mice, improve the spatial learning memory capacity of the mice and reinforcethe exploration spirit and the autonomic activity behavior of the mice.

Description

technical field [0001] The present invention relates to the field of chemistry. More specifically, the present invention relates to an application of tetrandrine and an extraction method of tetrandrine. Background technique [0002] Tetrandrine, also known as tetrandrine, also known as daodigongsu, tetrandrine A, is a colorless needle-like crystal, mainly used for analgesia, muscle relaxation, anti-allergic, anti-arrhythmia, antibacterial, anti-tumor and antihypertensive anticoagulant. Tetrandrine is mainly extracted from Tetrandrine. Fangji is the dried root of Fangji, a plant of the family Fangji, which has the effects of diuresis, swelling, wind and pain relief. Modern pharmacological experiments have shown that the total alkaloids of Fangji have analgesic, blood pressure-lowering, and muscle-relaxing effects. The content of alkaloids in tetrandrine is relatively high, generally up to 1.5-2.0%, among which tetrandrine is the main one, followed by fangchinoline. [000...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4748A61P39/00A61P25/00C07D491/18
CPCA61K31/4748A61P25/00A61P39/00C07D491/18
Inventor 左红艳杜丽娜金义光李杨张丽花朱思庆庞璐璐马金秋
Owner ACADEMY OF MILITARY MEDICAL SCI
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