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A technology of UFP-512, 1.UFP-512, applied in the field of biomedicine
Inactive Publication Date: 2019-10-22
THE FIRST PEOPLES HOSPITAL OF CHANGZHOU
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[0009] Most neurodegenerative diseases involve multiple systems of the body, so far there is no effective treatment that can delay or cure these diseases, and commonly used clinical drugs can only improve the clinical symptoms of patients in the early stages of the disease course
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[0036] The preparation methods of the above groups are:
[0037] The control group was normal cultured PC12 cells;
[0038] The MPP+ treatment group was replaced with 1.0mM MPP after the cells were subcultured for 24 hours + The new culture solution of neurotoxins was put back into the normal incubator and prepared after 24 hours of cultivation;
[0039] M+U group: 24 hours after the cells were subcultured, the new medium was replaced, and the DOR-specific agonist UFP-512 (5 μmol / L) was added to the new medium;
[0040] M+U+N group: 24 hours after the cells were subcultured, the new medium was replaced, and the DOR-specific agonist UFP-512 (5 μmol / L) and the DOR-specific inhibitor natrindole (1 μmol / L) were added to the new medium at the same time. L).
[0041] figure 2 a is several groups of fluorescence photos under the microscope, the weakening of the fluorescence intensity indicates the decrease of the mitochondrial membrane potential, comprehensive figure 2 The flo...
Embodiment 2
[0083] Example 2, as described in the background technology, type II diabetes, neurodegenerative diseases, and tumors are all closely related to mitochondrial dysfunction, so UFP-512 has the potential to prevent, delay, or treat mitochondria-related or affected mitochondria The application prospect of medicine for these diseases.
[0084] And UFP-512 protects mitochondria by regulating mitophagy, which can effectively resist the damage of various neurons. In various cell damage models, especially neurodegenerative diseases, such as Alzheimer's disease (AD) , amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) and other neurodegenerative diseases, and UFP-512 can effectively improve the depolarization of mitochondrial membrane potential, increase mitochondrial ATP output, and reduce oxidative stress. At the same time, UFP-512 can induce mitophagy dependent on PINK1-Parkin, thereby further clearing damaged mitochondria and maintaining the stability of mitochondrial...
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Abstract
The invention provides application of UFP-512 to mitochondria protection and autophagy induction, and provides application of the UFP-512 to preparing medicines for preventing or delaying or treatingsymptoms related to and affected by mitochondria. It is shown through experimental data that the UFP-512 can effectively improve the mitochondrial membrane potential depolarization, increase the mitochondria ATP yield and reduce the cellular oxidation stress. Meanwhile, the UFP-512 can induce the autophagy of the mitochondria depending on PINK1-Parkin, thereby further clearing away the damaged mitochondria and keeping the environment in the mitochondria stable, and the application gap of diseases related to mitochondria damage and mitochondria autophagy difficulty is made up through the targeted protection effect of the UFP-512 on the mitochondria and the induction effect of the UFP-512 on the autophagy of the mitochondria.
Description
technical field [0001] The present invention relates to the technical field of biomedicine, in particular to the use of UFP-512 in protecting mitochondria, inducing mitophagy and preparing medicines for preventing, delaying or treating diseases related to or affected by mitochondria. Background technique [0002] Mitochondria are widely found in the cells of various eukaryotic organisms and are important energy factories of the human body. Mitochondria generate ATP through the oxidative phosphorylation coupling electron transport chain in its inner membrane, which continuously provides energy to the body. In addition to synthesizing 90% of the body's ATP, mitochondria are also involved in a series of important metabolic processes, including fatty acid oxidation, iron metabolism, urea cycle and calcium storage. Mitochondria play an important role in human growth and development, disease, death and many other aspects. [0003] A large number of studies have shown that the oc...
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