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Composition containing resveratrol and application of composition

A technology of resveratrol and composition, which is applied in the fields of medicine and biology, and can solve the problems that resveratrol cannot effectively reduce patient weight and serum triglyceride content

Inactive Publication Date: 2019-11-08
PEKING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, resveratrol cannot effectively reduce the patient's body weight and serum triglyceride levels, and cannot fundamentally alleviate insulin resistance and liver cell inflammation

Method used

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  • Composition containing resveratrol and application of composition
  • Composition containing resveratrol and application of composition
  • Composition containing resveratrol and application of composition

Examples

Experimental program
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Embodiment 1

[0038] The mice used were: 8-week-old male, healthy SPF grade C57 mice, purchased from Beijing Weitong Lihua Company.

[0039] Raising conditions for C57 mice: ambient temperature 22±0.5°C, 12 hours / 12 hours alternating light and dark. The experimental data are expressed as mean ± standard error. The topiramate combined with resveratrol half-dose group was compared with the high-fat diet and blank solvent control, *P<0.05, **p<0.01, ***p<0.001, n=6.

[0040] Effects of topiramate combined with resveratrol on the body weight of obese mice induced by high-fat diet:

[0041] After a week of adaptive training with common feed, the mice were divided into two groups, one group continued to be fed with common feed, and the other group was fed with high-fat feed (the energy provided by fat accounted for 60% of the total energy) for 8 weeks. The average body weight of the fat-fed mice was 26.84 g, and the body weight of the normal-fed mice was 25.92 g; then the high-fat fed mice were...

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Abstract

The invention provides a composition containing resveratrol and application of the composition, and belongs to the technical field of medicine and biology. The composition is prepared from topiramateand resveratrol, wherein the mass ratio of topiramate to resveratrol is (1-5) to1. The composition can be used for lowering liver triglyceride, liver cholesterol, pyruvate transaminase, aspartate aminotransferase and triglyceride, thereby treating nonalcoholic fatty liver.

Description

technical field [0001] The invention belongs to the technical field of medicine and biology, and in particular relates to a composition containing resveratrol and its application. Background technique [0002] Overweight and obesity pose major health challenges in many countries around the world. The main feature of obesity is increased visceral fat, so it is also called abdominal obesity or central obesity. Obesity is often accompanied by "three highs", namely hyperglycemia, hypertension, and hyperlipidemia, which are defined as metabolic syndrome. Many studies have found that obesity can lead to complications such as type 2 diabetes, hyperlipidemia, non-alcoholic fatty liver disease, atherosclerosis, coronary heart disease, and obstructive sleep apnea-hypopnea syndrome. [0003] Nonalcoholic fatty liver disease (NAFLD) is a disease of abnormal lipid metabolism in liver cells. Early NAFLD manifests as lipid deposition in hepatocytes, accompanied by inflammation of hepato...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K31/05A61P1/16A61P3/06A61P3/10
CPCA61K31/137A61K31/05A61P1/16A61P3/06A61P3/10
Inventor 郑瑞茂王俊博王炳蔚苏志洁刘佳瑞
Owner PEKING UNIV
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