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A method for improving the service life of a storage-type powder mist drug delivery device

A technology of drug delivery device and powder aerosol, which is applied in the field of improving the service life of storage-type powder aerosol drug delivery device, and can solve the problems of poor powder fluidity and the like

Active Publication Date: 2021-09-10
SHANGHAI SINE YELLOW RIVER PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It adopts a coaxial vibrating gear and a new vibrating tooth shape design, which can improve the shortcomings of poor powder fluidity by providing vibration force, and can ensure the need for multiple vibrations for multi-dose storage powder aerosols, and can prevent vibration gears The appearance of wear and sticking can significantly improve the service life of the vibration gear, thereby effectively prolonging the service life of the entire storage-type powder mist delivery device

Method used

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  • A method for improving the service life of a storage-type powder mist drug delivery device
  • A method for improving the service life of a storage-type powder mist drug delivery device
  • A method for improving the service life of a storage-type powder mist drug delivery device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] For the vibrating gear of the vibrating gear and the vibrating tooth of the turntable, the second tooth surface adopts the conventional tooth surface generation form:

[0079] When the straight line R generated by the tooth surface does not intersect the rotation axis, the formula S R Both φ(t) and H(t) in (t)=φ(t)+H(t) are linear functions.

[0080] By drawing and processing the real object in this way, the torque of the relative rotation of the vibrating teeth is tested as follows:

[0081] project 10 20 30 40 50 60 70 80 90 100 Example 1 device 1 1.6 1.6 1.7 1.7 2.1 5.3 N / A N / A N / A N / A Example 1 device 2 1.5 1.6 1.7 1.9 4.3 N / A N / A N / A N / A N / A Example 1 device 3 1.7 1.6 1.8 2.0 5.7 N / A N / A N / A N / A N / A Example 1 device 4 1.6 1.6 1.7 1.8 1.9 2.7 6.1 N / A N / A N / A Example 1 device 5 1.6 1.6 1.7 1.7 2.1 3.1 5.8 N / A N / A N / A Example 1 device 6 1.5 1.5 1....

Embodiment 2

[0086] When the straight line R generated by the tooth surface intersects the axis, the formula S R Both φ(t) and H(t) in (t)=φ(t)+H(t) are linear functions.

[0087] By drawing and processing the real object in this way, the torque of the relative rotation of the vibrating teeth is tested as follows:

[0088] project 10 20 30 40 50 60 70 80 90 100 Example 1 device 1 2.3 2.3 2.3 2.4 2.3 2.3 2.3 2.3 2.3 2.3 Example 1 device 2 2.2 2.3 2.3 2.3 2.3 2.3 2.4 2.3 2.4 2.3 Example 1 device 3 2.3 2.2 2.3 2.3 2.4 2.4 2.3 2.3 2.3 2.4 Example 1 device 4 2.2 2.3 2.3 2.2 2.3 2.3 2.3 2.4 2.3 2.3 Example 1 device 5 2.4 2.3 2.3 2.4 2.3 2.3 2.2 2.3 2.3 2.3 Example 1 device 6 2.3 2.2 2.3 2.3 2.2 2.3 2.4 2.3 2.3 2.3 Example 1 device 7 2.2 2.3 2.2 2.3 2.3 2.3 2.3 2.3 2.3 2.3 Example 1 device 8 2.2 2.3 2.3 2.2 2.3 2.3 2.3 2.3 2.4 2.3 Example 1 device 9 2.3 ...

Embodiment 3

[0093] When the straight line R generated by the tooth surface intersects the axis, the formula S R In (t)=φ(t)+H(t), φ(t) is a quadratic function, and H(t) is a linear function.

[0094] By drawing and processing the real object in this way, the torque of the relative rotation of the vibrating teeth is tested as follows:

[0095]

[0096]

[0097] Note: 10, 20 to 100 represent the average torque recorded every ten times.

[0098] It can be seen from the data that the torque of the second tooth surface generated in this way does not show an increasing trend as the number of vibrations increases, and the torque of the vibrating teeth relative to the rotation is relatively average, and the average value is moderate.

[0099] Disassemble the storage-type powder mist drug delivery device, and observe that the second tooth surface of each vibrating tooth is relatively complete. The reason for the analysis is that during the relative rotation of such a curved surface, the secon...

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Abstract

The invention discloses a method for improving the service life of a storage-type powder mist drug delivery device, which belongs to the field of inhalation drug delivery devices. It sets a tooth surface whose length is the radius of the vibrating gear or turntable to generate a straight line; the tooth surface generates a straight line starting from the tooth bottom plane position of the vibrating gear or turntable, rotates and rises along the axis of rotation at the same time; during the rotation and rising process, On the opposite surface of the vibrating gear and the turntable, the tooth surface generates a straight line in a sweeping manner, and rotates to form a tooth-shaped curved surface of the second tooth surface of the lower vibrating tooth or the upper vibrating tooth. During the relative rotation between the vibrating gear and the turntable, viewed along the radial direction of the axis of rotation, the second tooth surfaces of the lower vibrating teeth and the upper vibrating teeth are in the form of a line contact structure. The technical solution can prevent the phenomenon of wear and sticking, and significantly improve the service life of the second tooth surface of the vibrating tooth. The invention can be widely used in the field of design and manufacture of the vibrating drug delivery unit of the storage type powder spray drug delivery device.

Description

[0001] The invention belongs to the field of devices for infusing a medium into or onto a human body, and in particular relates to a storage-type powder aerosol dosing device. Background technique [0002] Powder spray refers to micronized drug or in the form of capsules, vesicles or multi-dose reservoirs with carriers, using a special powder spray drug delivery device or inhalation device (or called an inhalation drug delivery device, also known as an inhalation drug delivery device in the past. Dry powder inhalation device or dry powder drug delivery device), a preparation form in which the patient actively inhales an aerosolized drug into the lungs. Inhalation powder spray relies on the patient's spontaneous breathing to make the drug powder enter the respiratory system, which has the characteristics of portability, low cost and strong stability. In recent years, the scope of application of inhaled powders has expanded from the traditional treatment of local lung diseases t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M15/00
CPCA61M15/0001
Inventor 谭中华卢望丁王然罗国军杜狄峥
Owner SHANGHAI SINE YELLOW RIVER PHARMA CO LTD
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