A kind of scorpion toxin active polypeptide hstx1 with improving cerebral ischemia and hypoxia and its preparation method and application

A technology of active polypeptide and cerebral ischemia, which is applied in the field of biomedicine to achieve the effect of strongly improving the activity of motor dysfunction, improving strong activity, and high efficiency and strong activity
CN110540585BActive Publication Date: 2022-07-01KUNMING MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
KUNMING MEDICAL UNIVERSITY
Publication Date
2022-07-01

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Abstract

The invention discloses a scorpion toxin active polypeptide HsTx1 capable of improving cerebral ischemia and hypoxia, and a preparation method and application thereof. The amino acid sequence of the scorpion toxin active polypeptide HsTx1 with improving cerebral ischemia and hypoxia is AGKKERAGSRRTKIVMLKCIREHGH. The tropical rainforest scorpion toxin polypeptide HsTx1 purified by the present invention shows strong anti-cerebral ischemia and hypoxia (MCAO) activities and improves motor dysfunction in the cerebral ischemia and hypoxia model (MCAO) experiment, indicating that the "scorpion toxin of the present invention can improve cerebral ischemia and hypoxia." Hypoxic active polypeptide HsTx1" has great medical application prospects. The scorpion toxin active polypeptide HsTx1 with improving cerebral ischemia and hypoxia described in the present invention has the beneficial characteristics of strong activity of effectively improving cerebral ischemia hypoxia and motor dysfunction.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to a scorpion toxin active polypeptide HsTx1 capable of improving cerebral ischemia and hypoxia, and a preparation method and application thereof. Background technique

[0002] As we all know, cerebral ischemia is one of the most common acute cerebrovascular diseases, and has been recognized as the third leading cause of mortality and disability in the world, causing huge economic and psychological burdens on individuals and socioeconomics. Acute cerebrovascular disease is a group of diseases that cause brain tissue damage, including ischemic and hemorrhagic stroke, due to the sudden rupture of blood vessels in the brain or the inability of blood to flow to the brain due to blockage of the blood vessels. Among them, the incidence of ischemic stroke is high, accounting for 60% to 70% of the total number of strokes, and its symptoms are unilateral head and face, sudden...

Claims

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