6 results about "Scorpion toxin" patented technology

The invention discloses a polypeptide composition for promoting skin desquamation and a preparation method and application thereof, the polypeptide composition comprises polypeptides and a polyol preservative, the polypeptides comprise a first polypeptide, a second polypeptide and a third polypeptide, and the first polypeptide is acetyl tetrapeptide-2; the second polypeptide comprises one or more of hyaluronic acid polypeptide, red scorpion toxin and palmitoyl tripeptide-5; and the third polypeptide is prepared from one or more of acetyl octapeptide-3, palmitoyl dipeptide-7, acetyl tetrapeptide-9 and acetyl tetrapeptide-11. The polypeptide composition can significantly up-regulate the gene expression of kallikrein through a synergistic effect and promote old cutin exfoliation; meanwhile, gene expression of metalloproteinase is inhibited, and light aging is delayed. The polypeptide composition disclosed by the invention can be prepared into various cosmetics and has multiple effects of promoting skin desquamation, resisting wrinkles and repairing barriers.

The invention discloses a medicine for treating diabetic retinopathy and application of scorpion venom heat-resistant synthetic peptide in treating the disease, belongs to the field of research and development of polypeptide medicines, and is used for treating or preventing the diabetic retinopathy (DR). Experimental results show that the scorpion venom heat-resistant synthetic peptide (SVHRSP) has the effect of preventing and treating diabetic retinopathy (DR) on a streptozotocin (STZ)-induced mouse experimental diabetes model, and can repress retinal function impairment caused by impairment of streptozotocin (STZ)-induced diabetic mouse retinal photoreceptor cells and retinal nerve inner layer cells; and retina structure damage caused by thinning of the retina thickness of a diabetic mouse induced by STZ (streptozotocin) is inhibited.

The application relates to the technical field of biological medicine engineering, and provides a preparation method and application of a scorpion toxin-derived transmembrane polypeptide. The OpiCalcin1 polypeptide is optimized in a truncation mode, two polypeptides Opi1 17-33 CSKKCKRRGTNPEKRCR and Opi1 23-33 RRGTNPEKRCR with excellent transmembrane function and low cytotoxicity are provided. Through experiment verification, the two cell transmembrane peptides have excellent transmembrane effect and low cytotoxicity, meanwhile, the defects of time-consuming and laborious in synthesizing the complete sequence of scorpion toxin OpiCalcin1 are overcome, the cell transmembrane peptides can be used for preparing drug, nuclear localization sequence and probe transport carriers, and the targeting efficiency is improved. Compared with traditional scorpion toxin medicine, the synthesis of the scorpion toxin to explore the transmembrane activity provides a new selection for the drug carrier.

The invention discloses a polypeptide kallikrein accelerant and application thereof, and belongs to the technical field of cosmetics, the polypeptide kallikrein accelerant comprises a polypeptide compound, a preservative and water, the polypeptide compound is at least one of red scorpion toxin, acetyl tetrapeptide-2, acetyl tetrapeptide-3, hexapeptide-11, hyaluronic acid polypeptide, palmitoyl tripeptide-5 and acetyl octapeptide-3, and the preservative is a mixture of glycerol, ethylhexylglycerol and 1, 2-ethylene glycol. The polypeptide kallikrein accelerant provided by the invention not only can promote skin desquamation by activating KLKs, but also can delay skin aging by inhibiting MMPs gene expression, and can be used for developing products with skin renewing and anti-aging dual effects.

The invention belongs to the field of biological medicine technology and food, and discloses application of scorpion toxin in preparation of weight-reducing medicine, and the scorpion toxin can be applied to preparation of the weight-reducing medicine, preparation of products for controlling fat accumulation in organisms, preparation of functional food for weight management and preparation of products for reducing the weight of the organisms. According to the application disclosed by the invention, the scorpion toxin can be used for reducing the body weight of an organism, reducing triglyceride and total cholesterol levels in serum, effectively relieving obesity and improving metabolic conditions such as glucose tolerance and insulin resistance, a new thought is provided for preventing and treating obesity and metabolic complications thereof, and the scorpion toxin has a wide clinical application prospect.

The application discloses a polypeptide kallikrein promoter and application thereof, and belongs to the technical field of cosmetics. The polypeptide kallikrein promoter comprises a polypeptide compound, a preservative and water. The polypeptide compound is at least one of red scorpion toxin, acetyl tetrapeptide-2, acetyl tetrapeptide-3, hexapeptide-11, hyaluronic acid polypeptide, palmitoyl tripeptide-5 and acetyl octapeptide-3. The preservative is a mixture of glycerol, ethylhexyl glycerin and 1,2-ethanediol. The polypeptide kallikrein promoter can not only promote skin desquamation by activating KLKs, but also delay skin aging by inhibiting MMPs gene expression, and can be used for developing products with skin renewal and anti-aging dual effects.