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Apparatus and method for assessing and treating cellulite

An orange peel, tissue technology, applied in biochemical equipment and methods, skin system evaluation, preparations for skin care, etc., can solve problems such as lack of patient-to-patient accuracy

Active Publication Date: 2019-12-06
ENDO VENTURES LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015]Thus, these scales of the prior art suffer from a number of disadvantages, including lack of accuracy from doctor to doctor and patient to patient

Method used

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  • Apparatus and method for assessing and treating cellulite
  • Apparatus and method for assessing and treating cellulite
  • Apparatus and method for assessing and treating cellulite

Examples

Experimental program
Comparison scheme
Effect test

example 1-C

[0339] Example 1 - Efficacy and safety of CCH for the treatment of EFP

[0340] In a phase 2a clinical trial of CCH for the treatment of cellulite, applicants demonstrated three doses of CCH (Low (0.06mg), Medium (0.48mg) and High (0.84mg)) showed improvements in the appearance of cellulite by the researchers' test endpoints and according to the overall cosmetic Measured by patient scores on the Outcome Improvement Scale (GAIS). Both the mid-dose and high-dose groups showed statistically significant improvements in cellulite appearance (measured by GAIS score) with p-values ​​< 0.05 compared to placebo for both endpoints. In the mid-to-high dose group, 68% of patients reported being "satisfied" or "very satisfied" with their treatment outcomes, compared with 34% of patients in the randomized placebo group. CCH was well tolerated in all dose groups, and most adverse events (AEs) were mild to moderate and mainly limited to the local injection area.

[0341] Applicants next...

example 2

[0403] Example 2 - Clinician-reported and patient-reported data using existing scales for measuring cellulite severity Comparison of reported cellulite severity scales

[0404] The Hexsel Cellulite Severity Scale (CSS) is an assessment tool currently used to measure the severity of cellulite. The Hexsel CSS rated each of the 5 domains of cellulite (number of apparent depressions, depression depth, morphological skin surface changes, skin laxity, laxity or sagging, and the Nürnberger and Müller classification) on a scale from "0" ( No change) to "3" (most severe).

[0405] In the phase 2 trial, the PR-PCSS was used to rate 4 anatomical quadrants of the buttocks and posterolateral thigh in adult women with edematous collagen fibrillar sclerosis (cellulite) at screening. Clinicians assessed and reported cellulite severity in the same 4 quadrants using CR-PCSS and HexselCSS. Those with moderate or severe cellulite (i.e., CR-PCSS score of 3 or 4, PR-PCSS score of 3 or 4, and ...

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Abstract

The present disclosure relates to a method for rating the severity of cellulite on a thigh or buttock in a human subject by utilizing a photonumeric scale that provides reliable results from physician-to-physician and patient-to-patient.

Description

[0001] related application [0002] This application claims U.S. Provisional Application Serial No. 62 / 465,622, filed March 1, 2017, Serial No. 62 / 485,705, filed April 14, 2017, and Serial No. 62 / 607,188, filed December 18, 2017 priority, the entire contents of which are hereby incorporated by reference to the fullest extent permitted by law. technical field [0003] The present invention relates to the field of assessment and treatment of edematous collagen fibril sclerosis (EFP or cellulite). Background technique [0004] Edematous collagen fibrillar sclerosis (EFP), commonly known as cellulite, is defined as a localized metabolic disturbance of the subcutaneous tissue that results in an abnormal contour of the skin. The condition manifests as dimples in the skin, especially in the gluteo-femoral area. EFP is caused by protrusion of subcutaneous fat lobules through subcutaneous junctions and / or shortening of collagenous septa that penetrate the subcutaneous layer and con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/103A61B5/00A61B5/107A61K38/00A61Q19/06
CPCA61B5/103A61B5/1079A61B5/441A61B5/444A61K38/4886A61K8/66C12Y304/24003A61B5/4848A61Q19/06A61P43/00A61B5/44
Inventor J·戴维森M·麦克莱恩刘艮舟
Owner ENDO VENTURES LTD
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