64 results about "Skin laxity" patented technology

The invention discloses a recombinant XII type collagen as well as a preparation method and application thereof. The amino acid sequence of the recombinant XII type collagen is any one of (A1)-(A3); (A1) is an amino acid sequence as shown in SEQ ID NO: 1; (A2) is an amino acid sequence which is obtained by substitution, deletion or insertion of one or more amino acid residues of the amino acid sequence as shown in SEQ ID NO: 1 and has the same functional protein; and (A3) is an amino acid sequence of a fusion protein obtained by connecting a protein tag to the N terminal or / and C terminal of the sequence (A1) or (A2). The recombinant XII type collagen provided by the invention has good antioxidant activity, and has a repairing effect on the problems of skin laxity, wrinkle increase and the like caused by degradation of type I collagen fibers of aged skin.

The invention relates to a green preparation method and application of an anti-saccharification tea extract, and belongs to the technical field of biology. The preparation method of the tea extract comprises the following steps: extracting tea by using a deep eutectic solvent to obtain the tea extract, and carrying out deproteinization and decoloration to obtain the tea extract. The hydrogen bond acceptor of the deep eutectic solvent comprises proline or betaine, and the hydrogen bond donor of the deep eutectic solvent comprises xylitol or glycerol. By utilizing the NaDES extraction technology, effective components can flow out by efficiently breaking cell walls, so that the extraction efficiency of tea active components represented by tea polyphenol is effectively improved; the selected NaDES solvent is natural, green and easy to obtain; the tea extract disclosed by the invention has an anti-saccharification effect, blocks glycosylation reaction, reduces and inhibits generation of AGEs, improves the problems of dark skin, skin laxity and aging caused by saccharification, reduces collagen loss, keeps skin elasticity and delays skin aging.

To efficiently generate effects with respect to sagging, firmness, spots, wrinkles, and lift-up of the skin.SOLUTION: Disclosed is a skin treatment device for generating effects with respect to sagging, firmness, spots, wrinkles, and lift-up of the skin. The skin treatment device applies AC stimulation within a range of 10 kHz or higher and lower than 200 kHz to the skin, thereby generating effects that are equal to or greater than those in the case of applying AC stimulation at 1 MHz, with respect to sagging, tightening, spots, wrinkles, and lift-up of the skin.SELECTED DRAWING: Figure 1

The invention relates to a composition with anti-inflammatory and anti-aging effects and application thereof, the composition comprises a dogwood extract, a radix fici simplicissimae extract and a guava extract, the composition can effectively scavenge free radicals, inhibit collagenase activity and inhibit generation of fluorescent AGEs, and the composition has the anti-inflammatory and anti-aging effects. Skin aging and skin laxity and darkness caused by glycosylation reaction are prevented. Meanwhile, by inhibiting NO secretion, the composition relieves skin inflammation reaction and can also improve skin microcirculation. All the components have a synergistic effect, so that the anti-oxidation, anti-inflammatory, anti-aging and anti-saccharification effects are remarkably enhanced, and the skin problems are comprehensively solved. No organic solvent is used in the process, the green and environment-friendly concept is met, the safety and reliability of the extract are ensured, and a mild and efficient solution is provided for anti-aging.

The invention relates to the technical field of skin dilators, and discloses an external skin dilator which comprises a main body assembly, an external skin dilator body and an external skin dilator body. The adjusting assembly is located on the bonding plate and comprises a fixing piece, the fixing piece comprises a first fixing block, a second fixing block and a third fixing block, and the first fixing block is fixed to the bonding plate. The dilator has the advantages that the dilator integrates the preoperative skin dilation function and the postoperative tension reduction function, the preoperative dilation function can continuously generate outward tension on the skin around a pre-operation, the slack area of the skin around the pre-operation is relatively enlarged, meanwhile, the tension reduction function can be achieved after the operation, the tension of the edge of a wound is reduced, and the wound healing effect is improved. The dilator is simple in structure and convenient to use, wound healing is facilitated, tension can be adjusted, the tension borne by skin is always within a safe and reasonable range, the dilator cannot shield an operation site in an operation, and it is guaranteed that a doctor can clearly observe and operate the operation area.

The invention discloses a polypeptide composition with repairing and anti-aging effects. The polypeptide composition is prepared from the following components in parts by weight: 0.001 to 0.1 part of acetyl tetrapeptide-11, 0.001 to 0.1 part of acetyl tetrapeptide-9, 0.001 to 0.1 part of acetyl tetrapeptide-2, 0.001 to 0.1 part of acetyl hexapeptide-8, 1 to 100 parts of silibinin, 1 to 500 parts of water and 3 to 500 parts of alcohol solvent. The invention further discloses a preparation process of the polypeptide composition and application of the polypeptide composition in cosmetics. The polypeptide composition disclosed by the invention has good repairing and anti-aging effects, and can be used for reducing skin laxity and wrinkles and improving the elasticity and compactness of skin.

Disclosed herein are apparatuses, kits, and methods for treating skin, such as skin tightening, e.g., reducing skin laxity, for treating conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning, and / or for generally improving skin function or appearance. Such apparatuses, kits, and methods include one or more hollow needles each having at least one prong and a mechanism for removing skin tissue portion(s) from the hollow needle(s).

The invention relates to the technical field of biomedical materials, in particular to a sodium hyaluronate composite solution for relieving skin aging and a preparation method thereof, the sodium hyaluronate composite solution comprises sodium hyaluronate, taurine, proline, glutamic acid, glycine and valine; sodium hyaluronate has a specific molecular weight, the composite solution has a specific pH value and osmotic pressure, and all the components have a synergistic effect, so that a moist environment is provided for skin, free radicals are removed, collagen synthesis is promoted, and aging phenomena such as skin laxity and wrinkles are improved. The composition can maintain skin moisture for a long time, scavenge free radicals, resist oxidation and promote collagen synthesis to improve skin aging, the preparation process guarantees stable components, the solution is matched with the physiological environment of the skin, and the composition is non-irritant, safe to use and good in anti-aging effect.

The invention discloses a face-protecting and skin-nourishing firming oil. Comprising the following components in parts by weight: 50 to 55 parts of caprylic / capric triglyceride, 25 to 35 parts of hydrogenated polyisobutene, 0.8 to 1.2 parts of tocopheryl acetate, 8 to 12 parts of sesame seed oil, 0.8 to 1.2 parts of caprylic / capric triglyceride, 0.8 to 1.2 parts of alkanet extract, 0.8 to 1.2 parts of oat kernel oil, 0.1 to 0.3 part of bisabolol, 0.1 to 0.3 part of rosemary leaf oil, 0.4 to 0.6 part of cardiospermum halicacabum flower / leaf / vine extract and 0.4 to 0.6 part of ginseng root extract. 0.4 to 0.6 part of camellia seed extract and 0.4 to 0.6 part of octyldodecanol. The compact oil has the advantages that the compact oil does not contain harmful ingredients such as heavy metals, and potential threats to health are avoided after the compact oil is used. The effect is lasting, the problems of skin laxity and the like are fundamentally solved, and the long-term tightening effect is gradually achieved.

To remove senescent cells and activate skin cells, and / or to remove senescent cells to prevent, inhibit, and ameliorate skin aging phenomena such as spots, wrinkles, sagging, skin thinning, skin fragility, and dryness, and activate skin cells.SOLUTION: A composition comprises at least one plant extract selected from the group consisting of Rosaceae Rosa, Perilla frutescens var. crispa, Japanese cherry, Coffea arabica, and Arnica montana.SELECTED DRAWING: None

The present disclosure relates to a novel peptide and a composition for alleviating skin aging, a composition for caring for skin damage or alleviating skin sagging, a composition for reversing aging, an anti-glycation composition, a composition for preventing hair loss or promoting hair growth, and a composition for improving skin barrier function, wherein the compositions comprise the novel peptide.

The invention relates to a lifting and tightening composition for skin as well as a preparation method and application thereof, and belongs to the technical field of cosmetics, the composition is prepared from the following raw materials: compound fermentation liquor, acetylated sodium hyaluronate, glycosylglycerol and a solvent, the compound fermentation liquor comprises a plant compound ingredient, cellulase, a lactobacillus rhamnosus activating solution, a saccharomyces cerevisiae activating solution and a fruit wine yeast activating solution; the plant compound ingredients comprise Chinese wolfberry fruits, litchi pericarp and grape seeds; the composition also comprises a sophora flower extract, a linden flower extract and Arabic gum. The lycium barbarum, the litchi pericarp and the grape seeds are compounded to serve as raw materials and fermented, the technology of first enzymolysis and then fermentation is adopted, the raw materials supplement one another, and the finished product effectively enables skin to have elasticity; in addition, the finished product prepared by the invention also has the effects of resisting aging, replenishing water and preserving moisture; in other words, multiple aspects in the system cooperate with one another, skin laxity is effectively improved, and the skin is lifted and tightened.

This invention relates to an anti-aging and repair composition containing hyaluronic acid peptides and its application. The composition comprises the following components: hyaluronic acid peptide composition, *Ulmus pumila* root extract, *Comfrey* extract, and *Alfalfa* extract; wherein the mass ratio of the hyaluronic acid peptide composition, *Ulmus pumila* root extract, *Comfrey* extract, and *Alfalfa* extract is (0.05-5):(0.1-3):(0.1-2):(0.1-2); the hyaluronic acid peptide composition includes yeast extract, collagen, and tetradecylaminobutyryl valine butyrate trifluoroacetate. The composition of this invention has a dual anti-aging effect of promoting collagen synthesis and inhibiting collagen degradation, effectively improving signs of aging such as skin laxity and fine lines. It also achieves a full-chain repair process of soothing, repairing, and strengthening, alleviating sensitivity and discomfort, strengthening the skin barrier, and ultimately achieving a highly effective and gentle anti-aging and repair effect.

The invention belongs to the technical field of cosmetics, and discloses a firming and anti-wrinkle composition as well as a preparation method and application thereof. The composition comprises the following components: kluyveromyces lactis / ganoderma sinensis fermentation product filtrate, sodium mannose phosphate and oligopeptide. Through the synergistic interaction of the kluyveromyces lactis / ganoderma sinensis fermentation product filtrate, the sodium mannose phosphate and the oligopeptide, the composition plays an inhibiting role in various aspects of skin laxity and aging from three key paths of enhancing cell viability, promoting tissue renewal and healing and promoting collagen generation; the aims of comprehensively and efficiently tightening and resisting wrinkles are fulfilled.

The invention relates to the technical field of cosmetics, and discloses an egg-derived protein peptide composition for promoting skin elasticity and resisting aging as well as a preparation method and application of the egg-derived protein peptide composition. The egg-derived protein peptide composition is characterized by being prepared from the following components in percentage by mass: 0.1 to 10 weight percent of PPP peptide, 0.1 to 5 weight percent of hen egg membrane polypeptide, 0.00001 weight percent of sialic acid glycopeptide, 2 to 10 weight percent of humectant, 0.1 to 5 weight percent of penetration enhancer, 0.1 to 5 weight percent of thickening agent, 2 to 8 weight percent of emulsifier, 0.1 to 0.3 weight percent of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.01 to 0.5 weight percent of preservative and the balance of water. According to the application, the three egg-derived protein peptides play roles from inside to outside, so that the skin elasticity, luster and thickness can be increased, the skin metabolism can be promoted, and the skin barrier can be improved from the two aspects of source skin cells and extracellular matrixes; the three peptides can be used for solving the problems of skin laxity, thinning and the like caused by external factors outwards, the three peptides mutually promote and synergistically act on the skin in all directions from a plurality of targets, and compared with a single peptide, the three peptides have more advantages. The three protein peptides can cooperate with one another from multiple levels to jointly promote the skin to be elastic, moist and compact.

The invention discloses an anti-aging composition containing recombinant collagen. The composition comprises the following components: (1) 2-5g of recombinant collagen; (2) 1-2 g of hyaluronic acid; (3) 0.2 to 0.5 g of a collagen degradation product; (4) 0.2 to 0.3 g of an anti-TGF (Transforming Growth Factor)-beta 1 monoclonal antibody; (5) 0.2 to 0.5 g of vitamin C; (6) 0.2 to 0.3 g of vitamin E; (7) 0.5-1 g of a green tea extract; and (8) adding the aqueous solution to 100 g. The anti-aging composition can effectively delay the skin aging process, improve the skin elasticity and reduce generation of wrinkles and fine wrinkles. The composition not only can be used in daily skin care products, but also can be used for treating skin problems caused by aging, such as skin laxity, fine wrinkles and darkness, and has a remarkable market prospect.

The objective is to provide a method for improving facial aging, utilizing a novel mechanism different from known methods for improving facial aging, such as loss of firmness and sagging, and from existing agents for improving facial aging. [Solution] Focusing on the relationship between skin sagging and the arrector pili muscles, this invention provides a cosmetic method to improve sagging, wrinkles, or hollowness by activating or proliferating arrector pili muscle cells.

The present invention addresses the problem of providing: an agent that is based on a new idea, is for preventing and / or ameliorating skin sagging and / or pore conspicuousness caused by the skin sagging, and is capable of easily obtaining a cosmetic effect similar to that of HIFU irradiation; and a new cosmetic method using the agent.　A preventing and / or ameliorating agent according to the present invention contains a high-intensity focused ultrasound (HIFU) irradiation-like effect agent, and is for preventing and / or ameliorating skin sagging and / or pore conspicuousness caused by the skin sagging.

A breast skin laxity measuring device is provided with a ruler main body used for being supported on a sternum plane and measuring breast skin laxity, a sliding part, a tension measuring part used for measuring tension and an adsorption part used for being fixed to a nipple, the sliding part is arranged on the ruler main body in a sliding and sleeving mode, and the tension measuring part is assembled with the sliding part. And the adsorption part is assembled with the tension measuring part. And the sliding part is perpendicular to the ruler main body. The ruler main body of the breast skin laxity measuring device is supported on the sternum plane, so that the measuring stability is improved, the tensile force can be accurately measured through the tensile force measuring part, and the measuring error is reduced.

Systems and methods utilizing RF energy to treat a patient's skin or other target tissues are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which RF energy can be selectively controlled to facilitate heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, all by way of non-limiting examples. In various aspects, the systems may include a flexible applicator comprising a plurality of layers, the plurality of layers comprises a first dielectric layer, a second dielectric layer, and a conductive layer, wherein the first dielectric layer and the second dielectric layer sandwich the conductive layer, the plurality of layers define a plurality of kerfs, an inner region and N regions extending from the inner region, wherein the plurality of kerfs divide the applicator into N regions.

The invention provides a repairing composition, a preparation method thereof and a repairing preparation, and belongs to the technical field of repairing product preparation. The repairing composition is prepared from the following raw materials in parts by weight: 5-20 parts of Chinese wolfberry fruits, 2-10 parts of scutellaria baicalensis roots, 1.5-9 parts of licorice roots and 4.5-20 parts of calamine. The repairing composition disclosed by the invention has an obvious inhibiting effect on hyaluronidase, so that the repairing composition has soothing and anti-allergy effects. Elastase can be effectively inhibited, completeness and elasticity of the skin structure can be maintained, skin laxity can be improved, wrinkles can be reduced, and the skin can be tight, elastic and moist.

It efficiently produces effects related to skin firmness, elasticity, blemishes, wrinkles, and lifting. [Solution] A skin treatment device is disclosed that generates effects on the skin related to sagging, firmness, blemishes, wrinkles, and lifting by applying AC stimulation in the range of 10 kHz to less than 200 kHz to the skin, thereby generating effects equivalent to or better than those obtained by applying AC stimulation at 1 MHz to the skin, and generating effects on the skin related to sagging, firmness, blemishes, wrinkles, and lifting.

The invention discloses a TGF-beta / Smad signal channel inhibitor. The TGF-beta / Smad signal channel inhibitor is prepared from the following components in parts by mass: 1000 parts of tea oil, 0.09 to 9.8 parts of bakuchiol and 0.01 to 0.2 part of acetyl hexapeptide-8, the invention also discloses a method for preparing the TGF-beta / Smad signal channel inhibitor as described above. The invention also discloses a cosmetic, which contains the TGF-beta / Smad signal channel inhibitor as an active component. The invention further discloses a method for evaluating the anti-aging effect of the cosmetic. According to the composition, by inhibiting abnormal activation of a TGF-beta / Smad signal channel, excessive deposition and crosslinking of an extracellular matrix are reduced, meanwhile, synthesis of collagen and elastin is promoted, aging characterization such as skin laxity and wrinkles is effectively improved, and deep repair and rejuvenation remodeling of skin aging damage are achieved.

The invention relates to the technical field of skin care products, and particularly discloses an anti-aging polypeptide composition as well as a preparation method and application thereof. According to the anti-aging polypeptide composition disclosed by the invention, through a multi-target-point and multi-layer synergistic effect, efficient wrinkle smoothing, tightening and anti-aging are realized. The anti-aging polypeptide composition can act on a neuromuscular joint and a dermal matrix at the same time, and has double effects of immediate improvement and long-term repair. According to the anti-aging polypeptide composition, the active ingredients and the penetration enhancer are synergistic, and compared with exogenous supplement collagen, the anti-aging polypeptide composition can be effectively absorbed in a transdermal mode, enhance the regeneration capacity of autologous collagen, better regulate extracellular matrixes and improve the anti-aging effect of the composition, and the anti-aging polypeptide composition has the advantages that by endogenous stimulation of regeneration of structural protein such as skin collagen, the anti-aging effect of the anti-aging polypeptide composition is improved, and the anti-aging effect of the anti-aging polypeptide composition is improved. The problem of skin laxity and aging caused by loss of structural proteins such as skin collagen is thoroughly solved, and the efficient wrinkle smoothing and anti-aging effects are achieved.

The invention relates to the technical field of medical instruments, and particularly discloses an automatic tightening tourniquet with a pressure monitoring function, which comprises a fixing plate and further comprises a pre-tightening mechanism arranged in the fixing plate and used for adjusting the pre-tightening degree of the skin of a patient; the adjusting mechanism is arranged on one side of the fixing plate, and the adjusting mechanism adjusts the wound pressure maintaining force of the patient; the instrument display mechanism is arranged on one side of the adjusting mechanism, the instrument display mechanism displays and reminds the pressure maintaining force of the wound, the two-way lead screw is driven to rotate through speed reduction transmission among the pre-tightening mechanism, the worm and the worm gear, so that the pre-tightening pieces on the two sides synchronously stretch the skin around the wound to be in a micro-tension state, and the wound is prevented from being damaged. The elastic deformation redundancy caused by skin laxity is thoroughly eliminated, the influence of skin elasticity on the pressure sensor is reduced, the elastic loss in the pressure transmission process is reduced from 30%-50% to 5% or below, and the pressure is prevented from being absorbed by skin deformation.

The invention discloses an extraction method of dihydroquercetin, a plant extract composition containing dihydroquercetin and application of the plant extract composition. The extraction method comprises the following steps: S1, drying and crushing raw materials; s2, raw material pretreatment; s3, raw material extraction; s4, water precipitation and centrifugation; s5, complexing extraction; s6, reverse extraction and concentration; and S7, crystallizing and drying. The extraction method disclosed by the invention is stable in process and suitable for industrial large-scale production and has a good market prospect, and the plant extract composition containing dihydroquercetin disclosed by the invention takes dihydroquercetin as a main component and cooperates with four components at the same time, can play a good antioxidant effect, is applied to a formula and has a good application prospect. The traditional Chinese medicine composition has good effects of removing excessive free radicals of a human body, improving skin laxity and resisting wrinkles, and can effectively relieve symptoms such as dark skin, obvious wrinkles and dry skin.

The present invention relates to a cosmetic composition containing an oxytocin secretion promoter containing an oranges essential oil, and a multi-aspect emotion improving agent. Provided is an oxytocin secretion-promoting agent which has a mood-improving effect in multiple aspects such as a reduction in tiredness and an improvement in positive mood, and also has a skin-improving effect such as a significant improvement in skin laxity, pores, and dry skin. The oxytocin secretion promoter contains orange essential oil.

The present application belongs to the technical field of exosome application, and discloses an exosome composition, which is obtained by mixing exosomes of Funaria hygrometrica, exosomes of Cnidium monnieri and exosomes of mesenchymal stem cells according to a mass ratio of 2-5:3-8:0.5-1. The exosomes of Funaria hygrometrica can significantly reduce the concentration of inflammatory factors, thereby achieving the effects of inhibiting excessive secretion of sebum and improving pores. The exosomes of Cnidium monnieri also synergize with the exosomes of Funaria hygrometrica to strengthen normal differentiation of keratinocytes, effectively alleviate excessive keratin layer multi-layering caused by excessive secretion of sebum, and thereby inhibit the volume increase of hair follicles. After the exosomes of mesenchymal stem cells and the plant exosomes are combined, the elasticity of the skin can be significantly improved, and the problem of skin laxity can be improved, so that the pores become more delicate, and the pores are significantly reduced in vision. The exosome composition of the present application has the effects of significantly improving coarse pores and increasing skin elasticity, can be made into various product forms, and has a wide application prospect.

The invention belongs to the technical field of cosmetics, and particularly relates to anti-wrinkle essence water and a preparation method thereof.The anti-wrinkle essence water is mainly capable of achieving the anti-wrinkle and skin care effects due to combination of multiple anti-wrinkle components in the anti-wrinkle essence water, the anti-wrinkle essence water has the effects of promoting skin metabolism, resisting oxidation and reducing inflammation due to matching of the different components in the anti-wrinkle essence water, and the anti-wrinkle essence water is free of side effects. The composition promotes synthesis of collagen by enhancing metabolism and promoting cell regeneration so as to improve skin laxity and wrinkles, improve skin compactness and achieve an anti-aging effect, reduces formation of fine wrinkles and wrinkles by resisting oxidation and neutralizing free radicals, reduces skin inflammation, regulates skin micro-ecology and slows down skin aging by resisting inflammation, and has a good anti-aging effect. In addition, the anti-wrinkle essence water also contains a plurality of moisturizing and soothing components, and the anti-wrinkle, moisturizing and soothing effects are mutually combined and mutually promoted.

The present invention relates to a composition with anti-inflammatory and anti-aging effects and its application. The composition comprises a cornus officinalis extract, a quinquefolia extract, and a guava extract. The composition can effectively scavenge free radicals, inhibit collagenase activity, inhibit the production of fluorescent AGEs, and prevent skin sagging and dullness caused by skin aging and glycation reactions. At the same time, the composition can alleviate skin inflammatory reactions and improve skin microcirculation by inhibiting the secretion of NO. The synergistic effect of the various ingredients significantly enhances the antioxidant, anti-inflammatory, anti-aging, and anti-glycation effects, providing a comprehensive solution to skin problems. This process does not use any organic solvents, conforms to the concept of green environmental protection, ensures the safety and reliability of the extract, and provides a gentle and efficient solution for anti-aging.