Preventing
skin aging by targeting multiple causes by a single bullet is of primal scientific and
consumer interest. A treatment based on compositions of compound (I) for
cellular senescence to control cellular degradation offers such a solution to multiple
skin ailments including
skin degradation from
cancer, diabetes,
radiation treatments,
chemotherapy, and sun-burn; mitochondrial dysfunction, age spots,
acne, loss of cellular antioxidants, collagen loss, loss of skin
pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from
radiation, damage from free radicals, damage from UV,
dry skin, xerosis,
ichthyosis,
dandruff, brownish spots, keratoses,
melasma, lentigines, liver spots,
pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin,
psoriasis, inflammatory dermatoses, topical
inflammation, disturbed keratinization, skin changes associated with aging,
scalp dryness, skin
depigmentation,
intracellular dehydration, and combinations thereof;