Application of oxymatrine in promoting scar repair

An oxymatrine and scar technology, applied in the field of medicine, can solve the problems of lack, unknown medicinal effect substances, complex Chinese herbal medicines and the like

Inactive Publication Date: 2020-01-03
谢岩
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the composition of Chinese herbal medicine is complex, the effective substances are unknown, and it lacks t

Method used

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  • Application of oxymatrine in promoting scar repair
  • Application of oxymatrine in promoting scar repair
  • Application of oxymatrine in promoting scar repair

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Experimental program
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Embodiment Construction

[0025] In order to illustrate the technical effects of the present invention more clearly, the present invention will be described below from two aspects of testing whether Oxymatrine (oxymatrine) has the effect of repairing scars and revealing the mechanism of Oxymatrine repairing hypertrophic scars.

[0026] 1. To test whether Oxymatrine (oxymatrine) has the effect of repairing scars.

[0027] (1) Construct a hypertrophic scar model of pig burns; figure 1 It is a pig full-thickness burn scar model.

[0028] A. Bama small experimental pig, B. Burn mold, C. Heating water tank, D. Manufacture of burn wound, E, elastic protective coat, F, burn wound at 3 weeks, G, wound debridement, H, 2 weeks after debridement Wound, I, wound 3 weeks after debridement, J, wound 4 weeks after debridement, K, hypertrophic scar formation 5 weeks after debridement.

[0029] (2) Clinical scar evaluation detection Oxymatrine promotes hypertrophic scar repair.

[0030] (3) Hematoxylin-eosin (H / E) s...

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Abstract

The invention provides application of oxymatrine in promoting scar repair, application of oxymatrine in drugs for the treatment of scars, application of oxymatrine in drugs for treatment of hyperplastic scars and application of oxymatrine in inhibiting autophagy of scar fibroblasts. Active ingredients in the drugs for the treatment of the scars are oxymatrine. Ingredients in the drugs for treatment of the hyperplastic scars include oxymatrine and auxiliary materials, and active ingredients are oxymatrine. A signal pathway of the oxymatrine for inhibiting the autophagy of the scar fibroblasts is AMPK/mTOR/p62/LC3-II.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of oxymatrine in promoting scar repair. Background technique [0002] Scar is a common complication after burns and trauma, which causes huge mental trauma, physical pain and heavy economic burden to patients. According to statistics, there are about 10 million burn patients in the world every year, and the incidence of scar after burn is 91.4%. Scars bring an expensive medical burden to patients, and the annual cost of scar treatment is estimated to be at least 4 billion US dollars. In addition, many complications, such as, itching, pain, insomnia, anxiety, loss of function, limitation of tissue movement, and most frighteningly, scar tissue can undergo malignant transformation into scar cancer. The current scar therapy is unsatisfactory, or the side effects are large, or the use cycle is long and expensive, and the ideal therapy needs to be continuously explor...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P17/02
CPCA61K31/4375A61P17/02
Inventor 谢岩邓兴旺谢楠强立娟马佳祥潘小亮赵芳张庆赵丹
Owner 谢岩
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