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Application of union of benzisoselenazolone derivative and metabolism resistant medicine to preparation of medicines for treating tumors

A technology of benzisoselenazole and tumor drugs, applied in the field of tumor treatment, can solve the problems of high toxicity and side effects, poor anti-cancer effect, etc., and achieve the effect of improving safety

Active Publication Date: 2020-02-18
SHANGHAI YUANXI MEDICINE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, anti-metabolite drugs generally have bone marrow toxicity in the second week after administration, often manifested as leukopenia and thrombocytopenia. cancer less effective

Method used

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  • Application of union of benzisoselenazolone derivative and metabolism resistant medicine to preparation of medicines for treating tumors
  • Application of union of benzisoselenazolone derivative and metabolism resistant medicine to preparation of medicines for treating tumors
  • Application of union of benzisoselenazolone derivative and metabolism resistant medicine to preparation of medicines for treating tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] Taking HepG2 cells as the target, BS and 5-FU were administered at the same time in a molar ratio of 2:1.

Embodiment 2

[0097] Taking HepG2 cells as the target, BS and 5-FU were administered at the same time in a molar ratio of 1:1.

Embodiment 3

[0099] Taking HepG2 cells as the target, BS and 5-FU were administered at the same time according to the molar ratio of 1:2.

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Abstract

The invention belongs to the technical field of tumor treatment, and discloses an application of the union of a benzisoselenazolone derivative and a metabolism resistant medicine to preparation of medicines for treating tumors. The benzisoselenazolone derivative has a structure of a compound as shown in a formula A. The metabolism resistant medicine is selected from one or more of a pyrimidine antagonist, a purine antagonist and a folic acid antagonist. The molar ratio of the benzisoselenazolone derivative to the metabolism resistant medicine is (1-10) to (1-10). The inventor of the inventionfinds that united application of BS and the metabolism resistant medicine (particularly 5-FU) has excellent synergistic inhibition effects on tumor cell proliferation, particularly obvious inhibitioneffects on liver cancer cell proliferation, and has great value on tumor treatment beyond all expectation.

Description

technical field [0001] The invention belongs to the technical field of tumor treatment, and specifically relates to the application of a benzisoselenazole derivative combined with an anti-metabolite drug in the preparation of a drug for treating tumors. Background technique [0002] Primary hepatocellular carcinoma (hereafter referred to as liver cancer) is one of the most common malignant tumors in humans. According to reports, the incidence of liver cancer ranks sixth among all malignant tumors in the world, while the mortality rate ranks third. In my country, about 383,000 people die of liver cancer every year, accounting for 51% of the global liver cancer deaths, which seriously threatens human life and health. [0003] Due to the rapid proliferation of liver cancer cells, it is difficult to diagnose in the early stage. When liver cancer is diagnosed, most patients have already developed to the advanced stage of liver cancer, and often accompanied by intrahepatic or ext...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/41A61K31/513A61P35/00A61P35/02
CPCA61K31/41A61K31/513A61P35/00A61P35/02A61K2300/00
Inventor 曾慧慧尹汉维
Owner SHANGHAI YUANXI MEDICINE CORP
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