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Method for control of fish parasites

一种寄生虫、鱼类的技术,应用在鱼类寄生虫的驱除领域,能够解决效果有限等问题,达到负担少、抑制耐性菌的效果

Inactive Publication Date: 2012-04-11
NIPPON SUISAN KAISHA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it is believed that the mechanism of action of lysozyme chloride or lactoferrin is to improve the non-specific body defense function of the host fish, and its effect is limited (non-patent document 1)

Method used

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  • Method for control of fish parasites
  • Method for control of fish parasites
  • Method for control of fish parasites

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Anthelmintic effects of oral administration of folic acid synthesis inhibitors and folic acid activation inhibitors on red sea bream parasitism-1

[0082]Test method: Raise 70 red sea bream with an average fish weight of about 20 g in a 200-liter water tank for about 7 days, and acclimate them at a water temperature of 25°C. During this period, commercially available feed (Nippon Suisan Co., Ltd., 2.5 mm in diameter initial sample EP (expanded) pellets) was fed, and the feeding rate was set at 2% of the fish body weight. Water injection was set at 2.4 L / min. Parasitic infection was carried out by dewatering a 200-liter tank and injecting about 200,000 individuals of hatchling larvae of Cryptocaryonum to expose the fish to the parasite for 1 hour. After exposure, 10 tails were housed in each of seven 100-liter water tanks. Water injection during feeding was set at 1.2 liters / minute. The test feed containing the drug was fed for 3 consecutive days, and the feeding time...

Embodiment 2

[0087] Anthelmintic Effects of Oral Administration of Folate Synthesis Inhibitors and Folate Activation Inhibitors on Red Sea Bream's Parasitism-2

[0088] Test method: 24 red sea bream with an average fish weight of about 39 g were reared in a 200-liter water tank for about 7 days, and domesticated at a water temperature of 25°C. During this period, commercially available feed (Nippon Suisan Co., Ltd., 2.5 mm in diameter initial sample EP (expanded) pellets) was fed, and the feeding rate was set at 2% of the fish body weight. Water injection was set at 2.4 L / min. The parasite infection was carried out by shutting off the water in a 200-liter tank, injecting about 170,000 individual Cryptocaryon larvae hatching, and exposing the fish to the parasite for 1 hour. After exposure, 8 tails were housed in three 100-liter water tanks respectively. Water injection during feeding was set at 1.2 liters / minute. The test feed containing the drug was fed for 3 consecutive days, 2 hours ...

Embodiment 3

[0093] Anthelmintic Effects of Oral Administration of Folate Synthesis Inhibitors and Folate Activation Inhibitors on Red Sea Bream's Parasitism-3

[0094] Test method: 56 red sea bream with an average fish weight of about 91 g were raised for about 12 days in a 500-liter water tank, and domesticated at a water temperature of 25°C. During this period, commercially available feed (Nippon Suisan Co., Ltd., 2.5 mm in diameter initial sample EP (expanded) pellets) was fed, and the feeding rate was set at 2% of the fish body weight. Water injection was set at 2.4 L / min. The parasitic infection was carried out by stopping the water in a 500-liter tank, injecting about 500,000 individual Cryptocaryon larvae hatching, and exposing the fish to the parasite for 1 hour. After exposure, 7 tails were housed in each of 8 100-liter water tanks. Water injection during feeding was set at 1.4 liters / minute. The test feed containing the drug was fed for 3 consecutive days, and the feeding tim...

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PUM

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Abstract

Disclosed is a method for controlling fish parasites, which comprises continuously administering a folic acid synthesis inhibitor and / or a folic acid activation inhibitor to a fish at a dose of 1 to 50 mg / kg fish body weight per day for one to two weeks. Preferably, a combination of a folic acid synthesis inhibitor and a folic acid activation inhibitor is used. As the folic acid synthesis inhibitor, a sulfa drug is preferred. As the folic acid activation inhibitor, a dihydrofolate reductase inhibitor, a folic acid antagonist, or the like can be used. The parasite control agent can control fish parasites through oral administration. The parasite control agent is particularly effective on ciliate fish parasites.

Description

technical field [0001] The invention relates to a method for expelling fish parasites. More specifically, it relates to a method for eliminating fish parasites, which uses a folic acid synthesis inhibitor and / or a folic acid activation inhibitor as an active ingredient. In particular, it relates to a method for removing fish parasites which are parasitic in farmed fish and become a problem. Background technique [0002] Since parasitic diseases prevent stable production in sea culture, it is a very big problem. Cryptocaryon stimuli belonging to the subkingdom Protozoa ciliates Cryptocaryon irritans White spot disease caused by parasitism in marine fish. As a result, the parasitic fish weakens to death. In recent years, the parasitism of Cryptocaryonia stimuli to farmed fish has become a serious problem in the Japanese aquaculture industry. currently reported to stimulate Cryptocaryon parasitism in flatfish Paralichthys olivaceus , Amberjack Seriola dumerili , Amberj...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/42A61K31/433A61K31/505A61K31/519A61K31/635A61P33/02A61P43/00C07D239/69C07D261/16C07D285/12C07D475/04C07D475/08
CPCA61K31/42A61K31/433A61K31/519A61K31/635A61K31/505A61K45/06A61P33/00A61P33/02A61P43/00A61K2300/00A61K9/0053
Inventor 河野文美平泽德高
Owner NIPPON SUISAN KAISHA LTD
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