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A kind of composite anti-scar silicone spray and preparation method thereof
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A technology of spray and silicone, which is applied in the field of medicine, can solve the problems of combined use, etc., to achieve the effect of reducing the degree of scars, reducing the formation of scar tissue, and inhibiting the proliferation of skin scar cells
Active Publication Date: 2020-06-02
浙江甬誉生物科技有限公司
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Problems solved by technology
Anti-scarring research on silicone, 5-fluorouracil and minoxidil has been reported, but there is no precedent for the combination of the three in the prior art
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Embodiment 1
[0021] A composite anti-scar silicone spray, comprising the following raw material components in percentage by weight: minoxidil 2%, 5-fluorouracil 0.3%, silicone 7%, sodium hyaluronate 1.5%, allantoin 1.5% %, phenoxyethanol 1%, and the balance is ethanol.
[0022] The silicone is purchased from Shanghai Resin Factory Co., Ltd., with a number average molecular weight of 2000 and a viscosity of 3000cp at 25°C.
[0023] The preparation method of the composite anti-scar silicone spray comprises the following steps: respectively weigh minoxidil, silicone, moisturizer, bacteriostat and appropriate amount of ethanol according to the weight ratio, mix and stir until completely dissolved, add the remaining ethanol to a specified amount; after standing and filtering the obtained medicinal solution, it is filled in a spray container filled with nitrogen gas and sealed, and the compound anti-scar silicone spray is obtained.
Embodiment 2
[0025] A composite anti-scar silicone spray, comprising the following raw material components in percentage by weight: 3% minoxidil, 0.6% 5-fluorouracil, 9% silicone, 2% glycerin, 3% propylene glycol, paraben Methyl ester 1.5%, the balance is ethanol.
[0026] The type of silicone and the preparation method of the composite anti-scar silicone spray are the same as in Example 1.
Embodiment 3
[0028] A composite anti-scar silicone spray, comprising the following raw material components in percentage by weight: 1.5% minoxidil, 0.4% 5-fluorouracil, 8% silicone, 2% butanediol, 2% betaine, Kason 1%, the balance is ethanol.
[0029] The type of silicone and the preparation method of the composite anti-scar silicone spray are the same as in Example 1.
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Abstract
The invention belongs to the field of medicine, and particularly relates to compound scar-resistant silicone spray and a preparation method thereof. The compound scar-resistant silicone spray comprises, by weight, 0.5-3% of minoxidil, 0.2-0.6% of 5-fluorouracil, 6-10% of silicone, 2-6% of a humectant, 0.5-2% of an antibacterial agent, and the balance of ethanol. The spray obtained by mixing minoxidil, 5-fluorouracil and silicone has an obvious effect on reducing scar tissue formation. Compared with the case having the absence of any one component, the spray with the combination of the three components can play a synergistic effect, the proliferation of skin scar cells can be remarkably inhibited, and the scar degree can be effectively reduced.
Description
technical field [0001] The invention belongs to the field of medicine, and in particular relates to a composite anti-scar silicone spray and a preparation method thereof. Background technique [0002] Scar is a common problem after surgery and trauma, which can affect the appearance in the slightest and affect the function in severe cases. There are many methods for treating hypertrophic scars in the past. Although good short-term results have been achieved, the long-term results are not satisfactory. In recent years, the molecular biological mechanism of hypertrophic scar formation has been further understood, such as bioactive factors (transforming growth factor-β, epidermal growth factor, fibroblast growth factor, etc.), apoptosis, endocrine (sex hormones, Prostaglandins, adrenal related hormones, etc.) etc. on scar hyperplasia. However, the mechanism of scar formation is still not fully understood. At present, the prevention and treatment of pathological scars are mai...
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