Whitening composition containing endothelin antagonist as well as preparation method and application thereof

A technology of endothelin antagonist and composition, which is applied in the direction of medical preparations containing active ingredients, skin care preparations, pharmaceutical formulations, etc., which can solve the problems of high transdermal absorption and no problem, and achieve transdermal absorption Good, high safety, high bioavailability effect

Inactive Publication Date: 2020-04-03
苏州绿叶日用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This new type of skin care product contains two different ingredients: one called Endoinosyn A (Endothelium Antagonists) that helps prevent excess pigmentation by blocking certain enzymes involved in producing melanins; another component called Lutonoxane B (LUTONX), also known as 2-(N-3 - dimethylaminopropionamide). These components work together to make it easier to remove unwanted colorations from our skirts without damaging their appearance over time.

Problems solved by technology

This patented technical solution involves developing new ways to make whiter teeth look better without causing any harmful side effects like dryness, yellowish appearance, dark circles around eyes, sensitivity to sunray light, dermatitis, rashiness, bleeding glare, sweatings, chaffeery smell, irritant reaction, deteriorated immune response, reduced photosynthesis efficiency, increased cellular stress factors, decreased melanosome formation rates, abnormal growth patterns associated with aggraftage processes during hair development. Existing methods involve adding chemical substances into tonifying compositions, leading them to degradations over time. There has long existed a challenge in achieving both desired results while minimizing negative impact on human cells involved in this process.

Method used

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  • Whitening composition containing endothelin antagonist as well as preparation method and application thereof
  • Whitening composition containing endothelin antagonist as well as preparation method and application thereof
  • Whitening composition containing endothelin antagonist as well as preparation method and application thereof

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preparation example Construction

[0028] The preparation method among the present invention, comprises the steps:

[0029] 1) mixing the complex phospholipid and emulsifier, stirring and heating until the solid material is completely melted, and cooling to room temperature to obtain an oil phase mixture;

[0030] 2) mixing the endothelin antagonist, polyhydric alcohol and water, and stirring evenly to obtain a water phase mixture;

[0031] 3) Add the oil phase mixture in step 1) to the water phase mixture in step 2), then add whitening agent and antioxidant, and then homogenize at a high speed to obtain a micro-emulsion;

[0032] 4) The micro-emulsion in step 3) is subjected to multiple times of high-pressure 300-1200 bar homogenization or high-speed micro-jet treatment to obtain a nano-emulsion with a particle size of 10-500 nm.

Embodiment 1

[0034] The whitening composition containing endothelin antagonist of the present embodiment consists of the following components in parts by weight:

[0035] Endothelin antagonist: 0.50 parts of emblica fruit extract, 0.50 parts of hydrolyzed conchiolin; whitening agent: 1.00 parts of Scutellaria baicalensis root extract, 5.00 parts of licorice root extract, 10.00 parts of Ascophyllum nodosum extract; antioxidant: Carnosine 1.00 parts; complex phospholipids: lecithin 2.00 parts, hydrogenated lecithin 3.00 parts; emulsifier: PEG-75 stearate 2.00 parts, polyglycerol-10 pentastearate 3.00 parts; polyol: butylene glycol 10.00 parts 3.00 parts of 1,2-hexanediol; 89.00 parts of water.

Embodiment 2

[0037] The whitening composition containing endothelin antagonist of the present embodiment consists of the following components in parts by weight:

[0038] Endothelin antagonist: emblica fruit extract 8.00 parts, undecylenoyl phenylalanine 2.00 parts; whitening agent: phenylethyl resorcinol 0.10 parts; antioxidant: edelweiss flower extract 5.00 parts, ginkgo biloba Leaf extract 5.00 parts; complex phospholipids: lysolecithin 7.00 parts, dipalmitoylphosphatidylcholine 3.00 parts; emulsifier: polysorbate-60 1.00 parts; polyols: butylene glycol 10.00 parts, 1,3- 10.00 parts of propylene glycol; 48.90 parts of water.

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Abstract

The invention discloses a whitening composition containing an endothelin antagonist and a preparation method thereof, which belong to the technical field of special cosmetics. The whitening composition containing the endothelin antagonist comprises the following components: 0.10 to 10.00 parts of the endothelin antagonist, 0.10 to 20.00 parts of a whitening agent, 0.10 to 10.00 parts of an antioxidant, 1.00 to 10.00 parts of composite phospholipid, 1.00 to 10.00 parts of an emulsifier, 2.00 to 20.00 parts of polyol and the balance of water, and the sum is 100 parts. The endothelin antagonist,the whitening agent and the antioxidant are loaded in the nano composition with the particle size of 10-500 nm, and the composition has the characteristics of synergistic interaction, targeted slow release, good transdermal absorption, high bioavailability, good stability, high safety and the like, so that the composition has the relatively ideal whitening effect.

Description

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Claims

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Application Information

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Owner 苏州绿叶日用品有限公司
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